Isihlambezo: Utilization patterns and potential health effects of pregnancy-related traditional herbal medicine

Varga, Christine; Veale, D.J.H.

doi:10.1016/s0277-9536(96)00104-9

Cited by 77 publications

(67 citation statements)

References 43 publications

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“…The assertion of some women on the use of herbal remedy to induce labour was in conjuction with the research conducted by Varga & Veale [3] and Goncalves [2] who confirmed that in pregnancy herbs are normally used orally on a regular basis as a tonic to clean the womb and attain an easy and quick delivery, and in order to protect the child from evil and have a heahlthy child.…”

Section: Discussionmentioning

confidence: 69%

“…These remedies are used by women to relieve minor symptoms of pregnancy such as nausea, vomiting, and low back pain, and also to prepare for labour or other unrelated health issues such as colds and respiratory illnesses or skin problems [1] . Herbal remedy may also be used to protect the fetus from evil in-vitro and to have a healthy child [2,3] . However, the use of herbal remedies may differ from women to women depending on their perception of their efficacy and supremacy above the conventional drugs which side effects may aggravate existing symptomatic manifestations of pregnancy.…”

Section: Introductionmentioning

confidence: 99%

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Women’s perception of safety and utilization of herbal remedies during pregnancy in a local government area in Nigeria

Olowokere

A.O.²

2013

Clinical Nursing Studies

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This descriptive study examined the perception of safety and utilization of herbal remedies during pregnancy using a convenience sampling of 300 women. The women who participated in the study were selected at household level from rural communities in Ife-North local government area of Osun state in Nigeria. Data was collected with the aid of semi-structured questionnaire using interviewer-administered method after informed consent had been taken from each participant. The results show that the women had positive perception about the safety and efficacy of herbs over conventional drugs in pregnancy. Greater percentage of the participants studied had used herbs at one point or the other during pregnancy. Local concoction also referred to as "Agbo" was the most used herbs by the women. The need for laboratory exploration of these herbs was emphasized by this study because of the high usage by pregnant women without any empirical evidence on its safety and efficacy.

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Section: Discussionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Women’s perception of safety and utilization of herbal remedies during pregnancy in a local government area in Nigeria

Olowokere

A.O.²

2013

Clinical Nursing Studies

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“…They are used for abortion, breast cancer, contraception, irregular or painful menstruation and conception (Steenkamp, 2003). In pregnancy herbs are normally used orally on a regular basis as a tonic to clean the womb (Varga and Veale, 1997), to attain an easy and quick delivery (Gumede, 1978), and in order to protect the child from evil and to have a healthy child (Gonçalves, 2001 …”

Section: Traditional Medicine In Pregnancy and Labour In South Africamentioning

confidence: 99%

Traditional medicine in late pregnancy and labour: perceptions of <i>kgaba</i> remedies amongst the Tswana in South Africa

Kooi

Theobald

2005

Afr. J. Trad. Compl. Alt. Med.

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In South Africa most black women use antenatal care services and deliver in clinics, and a considerable number complement this use of formal health services with traditional medicine. This study reported here examined the knowledge, beliefs and practical experiences of pregnant women, traditional healers and midwives with regard to kgaba (traditional medicine) and explored what constitutes kgaba. Interviews (N=30) and focus group discussions (N=21) were carried out among participants in Mogwase district in the North West Province of South Africa, where the use of kgaba remedies is commonly believed to cause foetal distress and an increase in caesarean sections. Findings indicated that kgaba remedies are ingested not only to prevent or solve physical problems but are also perceived as valuable in protecting against the harm that evil spirits can cause during pregnancy. Experiences with kgaba differed among participants and this may relate to the variety of plants used, their preparation and dosage. The use of crushed ostrich eggshell, which is perceived as inducing labour, emerged as an important finding. The use of kgaba as perceived by the Tswana is an important component in the experience of pregnancy and labour. However, communication about the use of kgaba between pregnant women and health staff was poor and hinders reporting or recording of dosage and evaluation of effects. There is a need to develop strategies that promote open dialogue between health providers and communities on the use of traditional medicine. Key words: traditional medicine, labour, ethnopharmacology, South Africa Terms usedIn this study the term traditional medicine (TM) is used for medicines of plant, animal or mineral origin, which are taken orally. The definition of tradition healer (TH) includes both diviners, who use bone throwing for diagnosis, and herbalists. Nowadays the distinction between these two healers is not always clear and they may be combined.

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“…Interestingly, 16.6% of the mothers with aneuploidy children took traditional medicine and 20% ate soil early in their pregnancy. There have been studies that associate taking traditional medicine with foetal abnormalities, uterine rupture, low birth weight [24,25]. HIV and its association of aneuploidy birth have not been reported.…”

Section: Discussionmentioning

confidence: 99%

Methyl Tetra Hydro Folate Reductase Enzyme Polymorphism in the Mothers with Previous Autosomal Aneuploidy Birth in the Indigenous African Population of Northern Region of South Africa

Duma¹,

Khine²

2017

J Down Syndr Chr Abnorm

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IntroductionAneuploidy is a genetic disorder where the total number of chromosomes is either less or more than the normal diploid number of 46, XX or 46, XY [1]. The most common aneuploidies in South Africa caused by autosomal chromosomal abnormalities include Down syndrome (Trisomy 21), Edward syndrome (Trisomy 18) and Patau syndrome (Trisomy 13). Globally the incidence for Down syndrome is about 1 in 650 to 1000 live births [2], Edward syndrome is 1 in 6000 live birth [3], and Patau is between 1 in 5000 to 29000 live birth [4]. Currently the prevalence rate is 1 out of 500 live birth for Down syndrome in South Africa with 1886 new cases diagnosed every year [5] and for Edward syndrome the prevalence is 1 in 4000 live birth and Patau is 1 in 8889 live birth [6,7]. The aetiology of these autosomal aneuploidies are believed to be due to non-disjunction of chromosome in maternal ovum during meiosis which is thought to be a sporadic, incidental event usually associated with older age group mothers. Notably, there is an increased incidence of aneuploidy babies has been observed in younger age group mothers with less than 35 years of age in South African black population [8].There were studies done in the Middle East families with recurrence aneuploidy births to determine if there is a genetic link. Krishna Murthy and Farag reported two unrelated Kuwaiti families each having 3 siblings with trisomy 21 as a result the researchers suggested that some genetic predisposition and gonadal mosaicism could be the underlying cause of recurrent aneuploidy in the younger mothers, thus increasing the risk of recurrence of such pregnancies [9]. There were studies that found that a particular polymorphism of one of these genes Methylenetetrahydrofolate reductase (MTHFR) might be a maternal risk factor for having child with Aneuploidy or Down syndrome and that a significant increase in plasma homocysteine levels exists in mothers of the children with Aneuploidy or Down syndrome [10,11].Increased homocysteine may result from dietary deficiency of folate and or vitamin B12 or from genetic polymorphism of Methylenetetrahydrofolate reductase (MTHFR). These genes encode the enzymes involved in the transfer of methyl group from sulpha containing amino acids (homocysteine and cysteine). Decreased transfer results in decrease methylation of DNA around the centromere region of chromosome 21, 18 and 13 proposed to be leading to aneuploidy. This hypothesis has led many researchers to further explore the evidence between DNA methylation of chromosome 21, 18, 13 in the unfertilized ovum but due to invasive nature of method involved in acquiring the pre-implementation studies, it has not been proven [10,[12][13][14][15][16].Indirect evidence of younger mothers having high level of plasma homocysteine with or without genetic polymorphisms would be the closest link to identifying the risk of recurrence aneuploidy in the AbstractBackground and purpose of the study: Aneuploidy births are highly prevalent in our population and some families, recurre...

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Isihlambezo: Utilization patterns and potential health effects of pregnancy-related traditional herbal medicine

Cited by 77 publications

References 43 publications

Women’s perception of safety and utilization of herbal remedies during pregnancy in a local government area in Nigeria

Women’s perception of safety and utilization of herbal remedies during pregnancy in a local government area in Nigeria

Traditional medicine in late pregnancy and labour: perceptions of <i>kgaba</i> remedies amongst the Tswana in South Africa

Methyl Tetra Hydro Folate Reductase Enzyme Polymorphism in the Mothers with Previous Autosomal Aneuploidy Birth in the Indigenous African Population of Northern Region of South Africa

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