Multi-user (MU), multiple-input, multiple-output (MIMO) detection has been extensively investigated, and many techniques have been proposed. However, further performance improvements may be constrained by limitations in classical computation. The motivation for this work is to test whether a machine that exploits quantum principles can offer improved performance over conventional detection approaches. This paper presents an evaluation of MIMO detection based on quantum annealing (QA) when run on an actual QA quantum processing unit (QPU) and describes the challenges and potential improvements. The evaluations show promising results in some cases, such as near-optimality in a QPSK-modulated 8×8 MIMO case, but poor results in other cases, such as for larger systems or when using 16-QAM. We show that some challenges of QA detection include dealing with integrated control errors (ICE), the limited dynamic range of QA QPUs, an exponential increase in the number of qubits to the problem size, and a high computation overhead. Solving these challenges could make QA-based detection superior to conventional approaches and bring a new generation of MU-MIMO detection methods.