ISL1, a novel regulator ofCCNB1,CCNB2andc-MYCgenes, promotes gastric cancer cell proliferation and tumor growth

Shi, Qiong; Wang, Weiping; Jia, Zhonghua; Chen, Ping; Ma, Kangtao; Zhou, Chen

doi:10.18632/oncotarget.9269

Cited by 67 publications

(64 citation statements)

References 33 publications

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“…These results were partially congruent with a previous study, which indicated that CENPF and BUB1B were good predictors of HCC therapy (9). In addition, CCNB2 is key protein of the cyclin family and regulates the progression of the G2/M transition during the cell cycle (46). Furthermore, CCNB2, MAD2L1 and MCM2 are mitotic checkpoint associated proteins that are overexpressed in numerous types of human cancer (47)(48)(49).…”

Section: Discussionsupporting

confidence: 87%

Integrative module analysis of HCC gene expression landscapes

Wei

et al. 2020

Exp Ther Med

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Despite hepatocellular carcinoma (HCC) being a common cancer globally, its initiation and progression are not well understood. The present study was designed to investigate the hub genes and biological processes of HCC, which change substantially during its progression. Three gene expression profiles of 480 patients with HCC were obtained from the Gene Expression Omnibus database. Subsequent to performing functional annotations and constructing protein-protein interaction (PPI) networks, 657 differentially expressed genes were identified, which were subsequently used to screen candidate hub genes. PPI networks were modularized using the weighted gene correlation network analysis algorithm, the topological overlapping matrix and the hierarchical cluster tree, which were utilized via STRING. Clinical data obtained from The Cancer Genome Atlas were then analyzed to validate the experiments performed using six hub genes. Additionally, a transcription factor and microRNA-mRNA network were constructed to determine the potential regulatory mechanisms of six hub genes. The results revealed that the oxidation-reduction process and cell cycle associated processes were markedly involved in HCC progression. Six highly expressed genes, including cyclin B2, cell division cycle 20, mitotic arrest deficient 2 like 1, minichromosome maintenance complex component 2, centromere protein F and BUB mitotic checkpoint serine/threonine kinase B, were confirmed as hub genes and validated via experiments associated with cell division. These hub genes are necessary for confirmatory experiments and may be used in clinical gene therapy as biomarkers or drug targets.

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Section: Discussionsupporting

confidence: 87%

Integrative module analysis of HCC gene expression landscapes

Wei

et al. 2020

Exp Ther Med

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“…It is well known that cyclin B1 is involved in G2-to-M transition and cyclin B2 is a G2/mitotic-specific factor. They both play a key role in the S-to-G2/M phases [57]. …”

Section: Discussionmentioning

confidence: 99%

The Natural Flavonoid Fisetin Inhibits Cellular Proliferation of Hepatic, Colorectal, and Pancreatic Cancer Cells through Modulation of Multiple Signaling Pathways

Youns

Hegazy

2017

PLoS ONE

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Digestive cancers are major causes of mortality and morbidity worldwide. Fisetin, a naturally occurring flavonoid, has been previously shown anti-proliferative, anti-cancer, neuroprotective, and antioxidant activities. In our study, the anti-tumor activities in addition to regulatory effects of fisetin on some cancer cell lines were investigated. Data presented here showed that fisetin induces growth inhibition, and apoptosis in hepatic (HepG-2), colorectal (Caco-2) and pancreatic (Suit-2) cancer cell lines. Gene expression results showed that 1307 genes were significantly regulated in their expression in hepatic and pancreatic cell lines. 350 genes were commonly up-regulated and 353 genes were commonly down-regulated. Additionally, 604 genes were oppositely expressed in both tumor cells. CDK5 signaling, NRF2-mediated oxidative stress response, glucocorticoid signaling, and ERK/MAPK signaling were among most prominent signaling pathways modulating the growth inhibitory effects of fisetin on hepatic and pancreatic cancer cells. The present analysis showed, for the first time, that the anti-tumor effect of fisetin was mediated mainly through modulation of multiple signaling pathways and via activation of CDKN1A, SEMA3E, GADD45B and GADD45A and down-regulation of TOP2A, KIF20A, CCNB2 and CCNB1 genes.

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“…CCNB2 can promote cell proliferation, migration and invasion in lung adenocarcinoma and hepatocellular carcinoma . In addition, CCNB1 and CCNB2 promoted gastric cancer cell proliferation and tumour growth . CDK1 and TOP2A played an important role in the regulation of cell cycle and regulated the proliferation of tumours .…”

Section: Discussionmentioning

confidence: 97%

Identification of hub genes and pathways in adrenocortical carcinoma by integrated bioinformatic analysis

Guo

et al. 2020

J Cellular Molecular Medi

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Adrenocortical carcinoma (ACC), a rare malignant neoplasm originating from adrenal cortical cells, has high malignancy and few treatments. Therefore, it is necessary to explore the molecular mechanism of tumorigenesis, screen and verify potential biomarkers, which will provide new clues for the treatment and diagnosis of ACC. In this paper, three gene expression profiles (GSE10927, GSE12368 and GSE90713) were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were obtained using the Limma package. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were enriched by DAVID. Protein-protein interaction (PPI) network was evaluated by STRING database, and PPI network was constructed by Cytoscape. Finally, GEPIA was used to validate hub genes' expression. Compared with normal adrenal tissues, 74 up-regulated DEGs and 126 down-regulated DEGs were found in ACC samples; GO analysis showed that up-regulated DEGs were enriched in organelle fission, nuclear division, spindle, et al, while down-regulated DEGs were enriched in angiogenesis, proteinaceous extracellular matrix and growth factor activity; KEGG pathway analysis showed that up-regulated DEGs were significantly enriched in cell cycle, cellular senescence and progesterone-mediated oocyte maturation; Nine hub genes (CCNB1, CDK1, TOP2A, CCNA2, CDKN3, MAD2L1, RACGAP1, BUB1 and CCNB2) were identified by PPI network; ACC patients with high expression of 9 hub genes were all associated with worse overall survival (OS). These hub genes and pathways might be involved in the tumorigenesis, which will offer the opportunities to develop the new therapeutic targets of ACC. | 4429GUO et al.

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ISL1, a novel regulator ofCCNB1,CCNB2andc-MYCgenes, promotes gastric cancer cell proliferation and tumor growth

Cited by 67 publications

References 33 publications

Integrative module analysis of HCC gene expression landscapes

Integrative module analysis of HCC gene expression landscapes

The Natural Flavonoid Fisetin Inhibits Cellular Proliferation of Hepatic, Colorectal, and Pancreatic Cancer Cells through Modulation of Multiple Signaling Pathways

Identification of hub genes and pathways in adrenocortical carcinoma by integrated bioinformatic analysis

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