ISL1/SHH/CXCL12 signaling regulates myogenic cell migration during mouse tongue development

Zhang, Wei; Yu, Jiaojiao; Fu, Guoquan; Li, Jianying; Huang, Huarong; Liu, Jing; Yu, Dongliang; Qiu, Mengsheng; Li, Feixue

doi:10.1242/dev.200788

Cited by 4 publications

(3 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While HH signaling guides embryonic muscle development [71,72], we found no Shh or HHresponding Gli1 expression in postnatal lingual muscles. This argues against direct HH control of tongue muscles, consistent with other studies suggesting stroma-mediated regulation of muscle development [68,69].…”

Section: Gas1 Is the Only Hh Pathway Component Identified In Lingual ...contrasting

confidence: 58%

Distinct expression patterns of Hedgehog signaling components in mouse gustatory system during postnatal tongue development and adult homeostasis

Kumari,

Franks,

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

The Hedgehog (HH) pathway regulates embryonic development of anterior tongue taste fungiform papilla (FP) and the posterior circumvallate (CVP) and foliate (FOP) taste papillae. HH signaling also mediates taste organ maintenance and regeneration in adults. However, there are knowledge gaps in HH pathway component expression during postnatal taste organ differentiation and maturation. Importantly, the HH transcriptional effectors GLI1, GLI2 and GLI3 have not been investigated in early postnatal stages; the HH receptors PTCH1, GAS1, CDON and HHIP, required to either drive HH pathway activation or antagonism, also remain unexplored. Using lacZ reporter mouse models, we mapped expression of the HH ligand SHH, HH receptors, and GLI transcription factors in FP, CVP and FOP in early and late postnatal and adult stages. In adults we also studied the soft palate, and the geniculate and trigeminal ganglia, which extend afferent fibers to the anterior tongue. Shh and Gas1 are the only components that were consistently expressed within taste buds of all three papillae and the soft palate. In the first postnatal week, we observed broad expression of HH signaling components in FP and adjacent, non-taste filiform (FILIF) papillae in epithelium or stroma and tongue muscles. Notably, we observed elimination of Gli1 in FILIF and Gas1 in muscles, and downregulation of Ptch1 in lingual epithelium and of Cdon, Gas1 and Hhip in stroma from late postnatal stages. Further, HH receptor expression patterns in CVP and FOP epithelium differed from anterior FP. Among all the components, only known positive regulators of HH signaling, SHH, Ptch1, Gli1 and Gli2, were expressed in the ganglia. Our studies emphasize differential regulation of HH signaling in distinct postnatal developmental periods and in anterior versus posterior taste organs, and lay the foundation for functional studies to understand the roles of numerous HH signaling components in postnatal tongue development.

show abstract

Section: Gas1 Is the Only Hh Pathway Component Identified In Lingual ...contrasting

confidence: 58%

Distinct expression patterns of Hedgehog signaling components in mouse gustatory system during postnatal tongue development and adult homeostasis

Kumari,

Franks,

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Therefore, we hypothesized that Shh acts downstream of Isl1 to mediate the interaction between the epithelium and the mesenchyme. Previous works have shown that ISL1 regulates the expression of Shh in the tongue and urethral epithelium ( 32 , 33 ). Both RNA-Seq and in situ hybridization results showed that Shh expression in the epithelium was reduced after Isl1 deletion.…”

Section: Discussionmentioning

confidence: 98%

ISL1 regulates lung branching morphogenesis via Shh signaling pathway

Huang,

Zhang,

Zheng

et al. 2023

Journal of Biological Chemistry

Self Cite

View full text Add to dashboard Cite

“…HH signaling is essential for embryonic myoblast migration (69, 70). Here we show that neither SHH nor HH signaling is present in the postnatal muscles.…”

Section: Discussionmentioning

confidence: 99%

Distinct expression patterns of Hedgehog signaling components In mouse gustatory system during postnatal tongue development and adult homeostasis

Kumari,

Franks,

et al. 2023

Preprint

View full text Add to dashboard Cite

It is well established that the Hedgehog (HH) pathway regulates embryonic development of anterior tongue taste fungiform papilla (FP) and the posterior circumvallate (CVP) and foliate (FOP) taste papillae, and taste organ maintenance and regeneration in adults. However, there are knowledge gaps in determining HH signaling regulation in postnatal taste organ differentiation and maturation. Importantly, the HH transcription factors GLI1, GLI2 and GLI3 have not been investigated in early postnatal stages; and, the receptors PTCH1, GAS1, CDON and HHIP, required to either drive HH pathway activation or antagonism, remain unexplored. UsinglacZreporter mouse models, we mapped expression of the HH ligand SHH, receptors, and transcription factors in FP, CVP and FOP in early and late postnatal and adult stages. In adults we also studied the soft palate, and the geniculate and trigeminal ganglia which extend afferent fibers to the anterior tongue.ShhandGas1are the only components that were consistently expressed within taste buds of all three papillae and the soft palate. In the first postnatal week, we observed a broad expression of HH signaling components in FP and adjacent, non-taste filiform (FILIF) papillae in epithelium or stroma and tongue muscles. Remarkably, we observed elimination ofGli1in FILIF andGas1in muscles, and downregulation ofPtch1in lingual epithelium and ofCdon,Gas1andHhipin stroma from late postnatal stage. Further, HH receptor expression patterns in CVP and FOP epithelium differed from anterior FP. Among all the components, only known positive regulators of HH signaling, SHH,Ptch1,Gli1andGli2, were expressed in the ganglia. Our studies emphasize differential regulation of HH signaling in distinct postnatal developmental periods and in anterior versus posterior taste organs, and lay the foundation for functional studies to understand the roles of numerous HH signaling components in postnatal tongue development.

show abstract

ISL1/SHH/CXCL12 signaling regulates myogenic cell migration during mouse tongue development

Cited by 4 publications

References 45 publications

Distinct expression patterns of Hedgehog signaling components in mouse gustatory system during postnatal tongue development and adult homeostasis

Distinct expression patterns of Hedgehog signaling components in mouse gustatory system during postnatal tongue development and adult homeostasis

ISL1 regulates lung branching morphogenesis via Shh signaling pathway

Distinct expression patterns of Hedgehog signaling components In mouse gustatory system during postnatal tongue development and adult homeostasis

Contact Info

Product

Resources

About