Islet Cell Autoimmunity in Women with Gestational Diabetes and Risk of Progression to Insulin-dependent Diabetes Mellitus

Mauricio, Dı́dac; Balsells, Montserrat; Morales, José Luis; Corcoy, Rosa; Puig-Domingo, Manel; Leiva, Alberto de

doi:10.1002/(sici)1099-0895(199612)12:4<275::aid-dmr170>3.0.co;2-w

Cited by 26 publications

(9 citation statements)

References 51 publications

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“…Longterm follow-up studies in women with or without gestational diabetes have indicated that GAD 65 -Ab positivity during pregnancy was a good predictor of clinical IDDM in later years. [168][169][170] In accordance with data at IDDM onset, the different types of autoantibodies were preferentially detected in subjects carrying the HLA DQA1*0301-DQB1*0302 haplotype. 130,167,171 For IAA an association was only found in the group under age 10 but for ICA and GAD 65 -Ab there was no clear age restriction.…”

Section: F Early Biological Markers and Prediction And Prevention Ofsupporting

confidence: 80%

Diabetes registries and early biological markers of insulin-dependent diabetes mellitus

Gorus

1997

Diabetes Metab. Rev.

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Section: F Early Biological Markers and Prediction And Prevention Ofsupporting

confidence: 80%

Diabetes registries and early biological markers of insulin-dependent diabetes mellitus

Gorus

1997

Diabetes Metab. Rev.

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“…A subset of women with gestational diabetes have evidence of islet cell autoimmunity, with prevalence of islet cell antibodies ranging from 1.6% to 38%, together with a variable incidence of other autoantibodies, including insulin autoantibodies and glutamic acid decarboxylase (GAD) antibodies, who may develop autoimmune diabetes in later life [58]. In a study from Japan, the prevalence of anti-GAD antibodies was 35.4% in all patients with Type 1 diabetes, 50.3% in patients with Type 1 diabetes of less than 1-year duration, 4.3% in patients with Type 2 diabetes and 10.5% in patients diagnosed with gestational diabetes, compared with 2.2% in normal subjects [59].…”

Section: Pathophysiology Of Gestational Diabetesmentioning

confidence: 99%

Diabetes and pregnancy: perspectives from Asia

et al. 2014

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There has been a marked increase in the prevalence of diabetes in Asia over recent years. Diabetes complicating pregnancy, in particular gestational diabetes, has also increased markedly in the region. Multi-ethnic studies have highlighted the increased risk of gestational diabetes mellitus among the different Asian populations. Prevalence of gestational diabetes in Asian countries varies substantially according to the screening strategy and diagnostic criteria applied, and ranges from 1% to 20%, with evidence of an increasing trend over recent years. The International Association for Diabetes in Pregnancy Study group criteria have been adopted by some Asian countries, although they present significant challenges in implementation, especially in low-resource settings. Studies on offspring of mothers with gestational diabetes have reported adverse cardiometabolic profiles and increased risk of diabetes and obesity. Gestational diabetes is likely to be a significant factor contributing to the epidemic of diabetes and other non-communicable diseases in the Asian region. In recognition of this, several large-scale prevention and intervention programmes are currently being implemented in different Asian countries in order to improve glucose control during pregnancy, as well as overall maternal health. Lessons emerging from gestational diabetes studies in Asia may help inform and provide insights on the overall burden and treatment strategies to target gestational diabetes, with the ultimate aim to reduce its adverse short-and long-term consequences.

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“…Furthermore, approximately 10% of women formerly classified as GDM have circulating islet-cell antibodies. These women may have a "dormant" form of T1DM (18 ). Specific HLA alleles (DR3 or DR4) appear to predispose women to the development of T1DM after delivery, as does the presence of islet-cell antibodies (19 ).…”

Section: Screening and Diagnosis During Pregnancymentioning

confidence: 99%

Pregnancy and Diabetes Management: Advances and Controversies

Castorino

Jovanovič

2011

Clinical Chemistry

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BACKGROUND:The treatment of diabetes in pregnancy has potentially far-reaching benefits for both pregnant women with diabetes and their children and may provide a cost-effective approach to the prevention of obesity, type 2 diabetes mellitus, and metabolic syndrome. Early and accurate diagnosis of diabetes in pregnancy is necessary for optimizing maternal and fetal outcomes.CONTENT: Optimal control of diabetes in pregnancy requires achieving normoglycemia at all stages of a woman's pregnancy, including preconception and the postpartum period. In this review we focus on new universal guidelines for the screening and diagnosis of diabetes in pregnancy, including the 75-g oral glucose tolerance test, as well as the controversy surrounding the guidelines. We review the best diagnostic and treatment strategies for the pregestational and intrapartum periods, labor and delivery, and the postpartum period, and discuss management algorithms as well as the safety and efficacy of diabetic medications for use in pregnancy.

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Islet Cell Autoimmunity in Women with Gestational Diabetes and Risk of Progression to Insulin-dependent Diabetes Mellitus

Cited by 26 publications

References 51 publications

Diabetes registries and early biological markers of insulin-dependent diabetes mellitus

Diabetes registries and early biological markers of insulin-dependent diabetes mellitus

Diabetes and pregnancy: perspectives from Asia

Pregnancy and Diabetes Management: Advances and Controversies

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