2018
DOI: 10.21926/obm.transplant.1901055
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Islet Identity in Transplantation Procedures: The Intersection of Cellular Maturity and Function

Abstract: Pancreatic islet transplantation holds promise for patients with insulin-dependent diabetes, but is severely limited by a shortage of cadaveric donor islets, and more so because of stringent inclusion criteria for organ donation including donor metabolic function, age, and comorbidities. The impact of these diverse factors on islet health has led to a broad investigation of global influences on islet biology, not least of all, characterization of mature, functional cellular identity and maintenance of appropri… Show more

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