Islet Transplantation: Growing Trans‐Species Islets in Tumor Extract‐Remodeled Testicles (Adv. Sci. 6/2019)

Abstract

In article number 1801694 , Junfeng Zhang, Chunming Wang, Lei Dong, and co‐workers biochemically remodel one of the two testicles of a mouse into a site that can protect xenogeneic islet cells from immune rejection. The transplants, both of primary origin and from a cancer source, can grow and function like a normal islet in the new host body, thus compensating for the glucose‐control function of the incapable pancreas.