Isn't There Room for Music in Chronic Pain Management?

Sihvonen, Aleksi J.; Pitkäniemi, Anni; Särkämö, Teppo; Soinila, Seppo

doi:10.1016/j.jpain.2022.01.003

Cited by 17 publications

(11 citation statements)

References 48 publications

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“…As shown in Table 2 , the VAS scores were lower in the intervention group, indicating that the music intervention was able to significantly reduce the patients’ subjective pain levels, providing some evidence of the positive effect of music intervention on chronic pain. This is related to the contribution of the limbic dopamine system of the brain to the affective component of pain perception ( Sihvonen et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of music intervention on subjective scores, heart rate variability, and prefrontal hemodynamics in patients with chronic pain

Shi

Fang

et al. 2022

Front. Hum. Neurosci.

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IntroductionMusic interventions have been proposed in recent years as a treatment for chronic pain. However, the mechanisms by which music relieves pain are unclear, and the effects of music intervention on physiological indicators in patients with chronic pain remain to be explored. This study aimed to explore whether a music intervention would have effects on subjective pain ratings, heart rate variability, and functional connectivity of the cerebral cortex in patients with chronic pain.MethodsA randomized controlled study was conducted on 37 pain patients aged 18–65 years, with the control group receiving usual care, and the intervention group receiving music intervention (8–150 Hz, 50–70 dB) for 30 min before bedtime for 7 days on top of usual care. Pain visual analog scale and heart rate variability were used as subjective and objective physiological indices before and after the music intervention, respectively. Changes in oxyhemoglobin and deoxyhemoglobin concentrations in the cerebral cortex were measured by functional near-infrared spectroscopy, and whole-brain correlation analysis was used to quantify the connectivity of prefrontal brain regions associated with the pain response.ResultsResults showed that patients with chronic pain in the intervention group had significantly lower visual assessment scale scores, as well as significantly lower overall voluntary mobility during pain episodes, resulting in relatively higher vagal innervation compared to the control group. In addition, connections between the bilateral dorsolateral prefrontal cortex (BA9, BA46) and frontal areas (BA10) were significantly higher in the intervention group.DiscussionThis study demonstrates the effectiveness of the combined application of music interventions with usual care in reducing pain levels in patients with chronic pain and provides insight into the pathological mechanisms of music interventions for analgesia, providing direction for new baseline indicators for quantitative clinical assessment of pain. The study was registered in the Chinese Clinical Trial Registry (No. ChiCTR2100052993).Clinical trial registration[https://www.chictr.org.cn/showproj.aspx?proj=136268], identifier [ChiCTR2100052993].

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Section: Discussionmentioning

confidence: 99%

Effect of music intervention on subjective scores, heart rate variability, and prefrontal hemodynamics in patients with chronic pain

Shi

Fang

et al. 2022

Front. Hum. Neurosci.

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“…Indeed, our perceptual system can predict and recognize musical patterns, and our reward system is satisfied by the emotional recognition of such patterns [ 20 ]. However, we cannot exclude that some effects (in the case of this study physiological effects) may result from the subjective pleasure of listening but also from specific music structures and specific music parameters [ 21 , 22 ].…”

Section: Methodsmentioning

confidence: 99%

Effect of Algorithmic Music Listening on Cardiac Autonomic Nervous System Activity: An Exploratory, Randomized Crossover Study

Raglio

Maestri

Robbi

et al. 2022

JCM

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It is proven that music listening can have a therapeutic impact in many clinical fields. However, to assume a curative value, musical stimuli should have a therapeutic logic. This study aimed at assessing short-term effects of algorithmic music on cardiac autonomic nervous system activity. Twenty-two healthy subjects underwent a crossover study including random listening to relaxing and activating algorithmic music. Electrocardiogram (ECG) and non-invasive arterial blood pressure were continuously recorded and were later analyzed to measure Heart Rate (HR) mean, HR variability and baroreflex sensitivity (BRS). Statistical analysis was performed using a general linear model, testing for carryover, period and treatment effects. Relaxing tracks decreased HR and increased root mean square of successive squared differences of normal-to-normal (NN) intervals, proportion of interval differences of successive NN intervals greater than 50 ms, low-frequency (LF) and high-frequency (HF) power and BRS. Activating tracks caused almost no change or an opposite effect in the same variables. The difference between the effects of the two stimuli was statistically significant in all these variables. No difference was found in the standard deviation of normal-to-normal RR intervals, LFpower in normalized units and LFpower/HFpower variables. The study suggests that algorithmic relaxing music increases cardiac vagal modulation and tone. These results open interesting perspectives in various clinical areas.

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“…In the context of music therapy for pain, we need more clarity regarding whether and what kind of music is a mediating (causal) or moderating (affecting strength and direction) variable in pain relief, and what other factors may lead to beneficial outcomes. Though many medical practitioners and scientists advocate for more rigorous and urgent investigation into music therapy and music interventions ( 8 ), such research is ethically and clinically difficult for music therapists ( 2 ). Systematic reviews are at the top of the Evidence Based Practice (EBP) hierarchy, whereas qualitative studies are lower [e.g., as cited in Melnyk, ( 9 )].…”

Section: Guiding Values For Research About Music Therapy For Painmentioning

confidence: 99%

“…Future researchers should assess whether new and refined interventions are feasible and can be made accessible for patients who have historically been marginalized from effective pain treatment, and they must intentionally study the impacts of systemic marginalization on the pain experience–including neurobiological effects. Researchers should integrate such findings with research on the effects of event-related and repeated trauma on the CNS, including to what degree symptoms of “catastrophizing” and “anxiety” ( 4 , 8 ) are related to trauma and pain response, and understanding how different music interventions could address limbic system overactivation. Such work could link neurological biomarkers to cognitive mechanisms of music interventions for pain ( 5 ).…”

Section: Guiding Values For Research About Music Therapy For Painmentioning

confidence: 99%

Mechanistic research approaches in music therapy for pain: Humanizing and contextualized options for clinician-researchers

Hunt

2022

Front. Pain Res.

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Isn't There Room for Music in Chronic Pain Management?

Cited by 17 publications

References 48 publications

Effect of music intervention on subjective scores, heart rate variability, and prefrontal hemodynamics in patients with chronic pain

Effect of music intervention on subjective scores, heart rate variability, and prefrontal hemodynamics in patients with chronic pain

Effect of Algorithmic Music Listening on Cardiac Autonomic Nervous System Activity: An Exploratory, Randomized Crossover Study

Mechanistic research approaches in music therapy for pain: Humanizing and contextualized options for clinician-researchers

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