2024
DOI: 10.3389/fphar.2024.1453205
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Isoalantolactone: a review on its pharmacological effects

Guang Yang,
Longfei Yang,
Fei Xu

Abstract: Isoalantolactone (ISA) is a sesquiterpene lactone that could be isolated from Inula helenium as well as many other herbal plants belonging to Asteraceae. Over the past 2 decades, lots of researches have been made on ISA, which owns multiple pharmacological effects, such as antimicrobial, anticancer, anti-inflammatory, neuroprotective, antidepressant-like activity, as well as others. The anticancer effects of ISA involve proliferation inhibition, ROS overproduction, apoptosis induction and cell cycle arrest. Th… Show more

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