Isoalantolactone protects against Staphylococcus aureus pneumonia

Qiu, Jiazhang; Luo, Mingjing; Wang, Jianfeng; Dong, Jing; Li, Hongen; Leng, Bingfeng; Zhang, Qian; Dai, Xianzhong; Zhang, Yu; Niu, Xiaodi

doi:10.1111/j.1574-6968.2011.02397.x

Cited by 44 publications

(33 citation statements)

References 37 publications

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“…The DU 1090 strain, an Hla-mutant of S. aureus 8325-4, caused almost no cell injury to the S. aureus in an A549 cell co-culture system. However, A549 cells were killed when cultured with S. aureus 8325-4 (Qiu et al 2011a). These studies suggested that Hla can be considered as a potential anti-virulence therapeutic target for against S. aureus infection, particularly for S. aureus pneumonia.…”

Section: Discussionmentioning

confidence: 96%

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Imperatorin inhibits the expression of alpha-hemolysin in Staphylococcus aureus strain BAA-1717 (USA300)

Ouyang

Chen

Sun

et al. 2016

Antonie van Leeuwenhoek

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Both community-associated and hospital-acquired infections with methicillin-resistant Staphylococcus aureus (MRSA) have been increasingly reported around the world in the past 20 years. In 2006, the Centers for Disease Control and Prevention reported that 64 % of MRSA isolates were of the USA300 clonal type in infected patients in USA. The aim of our study was to estimate the in vitro effect of imperatorin on MRSA strain BAA-1717 (USA300). The effects of imperatorin on alpha-hemolysin (Hla) production, when strain BAA-1717 was co-cultured with sub-inhibitory concentrations of imperatorin, were analysed using susceptibility testing, hemolysis assays, western blotting and real-time PCR. Live/Dead analysis and cytotoxicity assays were employed to examine the protective effect of imperatorin against the strain BAA-1717-mediated injury of human alveolar epithelial cells (A549). The results showed that imperatorin has no anti-S. aureus activity at the tested concentrations in vitro. However, imperatorin can observably inhibit the production of Hla in culture supernatants and reduce the transcriptional levels of hla (the gene encoding Hla) and arg (the accessory gene regulator). Imperatorin prevented Hla-mediated A549 epithelial cell injury in a co-culture system. In conclusion, our results suggested that imperatorin has the potential to be developed as a new anti-virulence drug candidate for managing S. aureus infection.

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Section: Discussionmentioning

confidence: 96%

“…Previous studies have indicated that many natural products can affect the production of Hla by S. aureus and have therapeutic effects on S. aureus pneumonia in a mouse model (Qiu et al 2010(Qiu et al , 2011aWang et al 2015;Zhou et al 2015). Imperatorin (9-(3-Methylbut-2-enoxy)-7-furo[3, 2-g]chromen-7-one), a furocoumarin compound (Fig.…”

Section: Introductionmentioning

confidence: 99%

Imperatorin inhibits the expression of alpha-hemolysin in Staphylococcus aureus strain BAA-1717 (USA300)

Ouyang

Chen

Sun

et al. 2016

Antonie van Leeuwenhoek

Self Cite

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“…Mitochondria have become an important component of the apoptosis execution machinery, cytochrome c, initiator in the mitochondrial apoptosis pathway, and can be released from the intermembrane of mitochondria after mitochondria depolarization (106)(107)(108).…”

Section: Targeting Cancer Cells By Mitochondriamediated Apoptosis Patmentioning

confidence: 99%

Targeting Apoptosis Pathways in Cancer and Perspectives with Natural Compounds from Mother Nature

Millimouno

Dong

Liu

et al. 2014

Cancer Prevention Research

236

168

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Although the incidences are increasing day after day, scientists and researchers taken individually or by research group are trying to fight against cancer by several ways and also by different approaches and techniques. Sesquiterpenes, flavonoids, alkaloids, diterpenoids, and polyphenolic represent a large and diverse group of naturally occurring compounds found in a variety of fruits, vegetables, and medicinal plants with various anticancer properties. In this review, our aim is to give our perspective on the current status of the natural compounds belonging to these groups and discuss their natural sources, their anticancer activity, their molecular targets, and their mechanism of actions with specific emphasis on apoptosis pathways, which may help the further design and conduct of preclinical and clinical trials. Unlike pharmaceutical drugs, the selected natural compounds induce apoptosis by targeting multiple cellular signaling pathways including transcription factors, growth factors, tumor cell survival factors, inflammatory cytokines, protein kinases, and angiogenesis that are frequently deregulated in cancers and suggest that their simultaneous targeting by these compounds could result in efficacious and selective killing of cancer cells. This review suggests that they provide a novel opportunity for treatment of cancer, but clinical trials are still required to further validate them in cancer chemotherapy. Cancer Prev Res; 7(11);

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“…Current literature shows that alantolactone and isoalantolactone possess various antimicrobial [3], antiinflammatory [4], and antitumor activities [5][6][7][8][9][10] both in vivo and in vitro. A recent study done by the team revealed that alantolactone and isoalantolactone could significantly relieve irritable bowel syndrome (IBS) by regulating neurotransmitters, gastrointestinal hormones, and intestine propulsive movement.…”

Section: Introductionmentioning

confidence: 99%

Metabolism Analysis of Alantolactone and Isoalantolactone in Rats by Oral Administration

Wang

Peng

et al. 2018

Journal of Chemistry

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Alantolactone and isoalantolactone are the major active ingredients of Inulae Radix. Their metabolism in vivo and in vitro was investigated by UPLC-Q-TOF-MS for the first time. As a result, nine metabolites in vivo including cysteine conjugates, oxidates, dehydrogenates, and hydrates were detected in rat bile after oral administration. The metabolites produced in vitro by incubation with rat liver microsomes were found to be substantially identical to those detected in vivo. However, no metabolites were detected in the samples of plasma, feces, and urine or in the incubates of gastric juice, intestinal juice, and intestinal bacteria. These results reveal that the liver is the main metabolic organ for alantolactone and isoalantolactone, and the first pass effect of the liver appears to be the reason for the low oral bioavailability of the two lactones.

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Isoalantolactone protects against Staphylococcus aureus pneumonia

Cited by 44 publications

References 37 publications

Imperatorin inhibits the expression of alpha-hemolysin in Staphylococcus aureus strain BAA-1717 (USA300)

Imperatorin inhibits the expression of alpha-hemolysin in Staphylococcus aureus strain BAA-1717 (USA300)

Targeting Apoptosis Pathways in Cancer and Perspectives with Natural Compounds from Mother Nature

Metabolism Analysis of Alantolactone and Isoalantolactone in Rats by Oral Administration

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