1977
DOI: 10.1073/pnas.74.7.3023
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Isoantigenic expression of Forssman glycolipid in human gastric and colonic mucosa: Its possible identity with “A-like antigen” in human cancer

Abstract: The heterogenetic Forssman antigen is a glycosphingolipid, a ceramide pentasaccharide with the structure GalNAcal-s-3GalNAc,1-a3Galal---4Gal,1--.4Glc-.ceramide. Forssman-positive

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Cited by 162 publications
(70 citation statements)
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“…30 GBGT1 is transcribed in several human tissues but does not appear to result in Fs antigen expression. 15 However, Fs antigen may be expressed in carcinomas 41,42 and has been suggested to constitute the so-called incompatible A antigen found in nongroup-A individuals with cancer. 42 We demonstrated here for the first time that GBGT1-mRNA is readily detectable in human blood and erythroid bone marrow cultures at levels similar to, if not higher than, ABO-mRNA.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…30 GBGT1 is transcribed in several human tissues but does not appear to result in Fs antigen expression. 15 However, Fs antigen may be expressed in carcinomas 41,42 and has been suggested to constitute the so-called incompatible A antigen found in nongroup-A individuals with cancer. 42 We demonstrated here for the first time that GBGT1-mRNA is readily detectable in human blood and erythroid bone marrow cultures at levels similar to, if not higher than, ABO-mRNA.…”
Section: Discussionmentioning
confidence: 99%
“…15 However, Fs antigen may be expressed in carcinomas 41,42 and has been suggested to constitute the so-called incompatible A antigen found in nongroup-A individuals with cancer. 42 We demonstrated here for the first time that GBGT1-mRNA is readily detectable in human blood and erythroid bone marrow cultures at levels similar to, if not higher than, ABO-mRNA. 43 This indicates that Fs synthase is probably expressed in erythroid progenitors and thus able to make Fs on RBCs if mutated Arg296Gln.…”
Section: Discussionmentioning
confidence: 99%
“…TSCs, thymic stromal cells; DC, dendritic cell. means to synthesize the Forssman Ag, it is only expressed in certain mammary and colonic tumors (19,27), presenting a potential tumor-specific determinant. In mice it is differentially expressed throughout development and in adult mesenchymal tissues (28,29).…”
Section: Discussionmentioning
confidence: 99%
“…The presence of terminal non-reducing GalNAc was made plausible by the affinities of HSV glycoproteins for SBA and HPA. These characteristics distinguish certain gC oligosaccharides involved from those of the N-glycosidic, high-mannose and complex types (Kobata, 1979) and suggest structural similarities with oligosaccharides of glycoconjugates such as those constituting several blood group substances and the Forssman antigens (Donald et al, 1982;Hakomori et al, 1977). In the present paper, glycoproteins of HSV-infected cells were purified by immunosorbent techniques and HPA affinity chromatography of the protease-digested glycoproteins.…”
Section: Discussionmentioning
confidence: 99%