Isobaric heat capacity of 1,2-propanediol at high temperatures and high pressures

Зарипов, З. И.; Aetov, Almaz U.; Nakipov, Ruslan R.; Хайрутдинов, В. Ф.; Гумеров, Ф. М.; Abdulagatov, Ilmutdin M.

doi:10.1016/j.molliq.2020.112935

Cited by 8 publications

(2 citation statements)

References 11 publications

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“…Currently, PG is generally recognized as a safe food additive, which is oversupplied in Chinese market (Phillips et al, 2017;Tao et al, 2020;Zhao et al, 2020). PG has very low toxicity and is considered to be a non-toxic or non-carcinogenic compound for adults (Zaripov et al, 2020). However, newborns and infants are specially susceptible to the effects of PG (Massarsky et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…PG can dissolve hydrophobic substances, it is commonly present in poorly water-soluble intravenous medications and activated charcoal preparations (Greene et al, 2020). Because of PG has very low toxicity and is currently considered as a noncarcinogenic or nongenotoxic compound, it is important liquid for industrial and technological applications (Zaripov et al, 2020). As an important and safe intermediate, PG has been used in several industrial areas (Ferreira et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Developmental toxicity and neurotoxicity assessment of R-, S-, and RS-propylene glycol enantiomers in zebrafish (Danio rerio) larvae

Shen

Zhao

et al. 2022

Environ Sci Pollut Res

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Propylene glycol (PG) is widely used in the foods, pharmaceuticals, oil industry, animal feed, cosmetics and other industries. Because of the existence of a chiral carbon center, PG forms R (Rectus)-and S (Sinister)-enantiomers. Currently, the toxicity study of its R-, S-enantiomers is still very scarce. In this study, we have assessed the developmental toxicity and neurotoxicity of the R-, S-, and RS-PG enantiomers in zebra sh larvae. We found that exposure to R-, S-, and RS-PG enantiomers did not signi cantly affect the basic developmental endpoints of embryos or larvae (i.e., embryonic movement, hatching, mortality, malformation, heartbeat, body length), indicating that R-, S-, and RS-PG exposures did not exhibit the basic developmental toxicity in zebra sh larvae. The toxicity of the three enantiomers was lower than that of ethanol, and there was no signi cant difference between them. However, R-, S-, and RS-PG exposures with high doses could signi cantly change the eye diameter and the locomotor activity of larval zebra sh, indicating that R-, S-, and RS-PG enantiomers of high doses can potentially exhibit the neurotoxicity and ocular developmental toxicity in zebra sh larvae. Therefore, the potential neurotoxicity and ocular developmental toxicity of R-, S-, and RS-PG enantiomers for infants and toddlers should be considered.

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