Isobavachin attenuates osteoclastogenesis and periodontitis-induced bone loss by inhibiting cellular iron accumulation and mitochondrial biogenesis

Li, Ting; Du, Yangge; Yao, Hantao; Zhao, Boxuan; Wang, Zijun; Chen, Rourong; Ji, Yaoting; Du, Minquan

doi:10.1016/j.bcp.2024.116202

Biochemical Pharmacology

2024

DOI: 10.1016/j.bcp.2024.116202

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Isobavachin attenuates osteoclastogenesis and periodontitis-induced bone loss by inhibiting cellular iron accumulation and mitochondrial biogenesis

Ting Li,

Yangge Du,

Hantao Yao

et al.

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2024

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Cited by 2 publications

References 78 publications

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Mitochondria in skeletal system-related diseases

Pei,

Yao,

Liang

et al. 2024

Biomedicine & Pharmacotherapy

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Mitochondria in skeletal system-related diseases

Pei,

Yao,

Liang

et al. 2024

Biomedicine & Pharmacotherapy

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Causal Relationship between Mitochondrial Biological Function and Periodontitis: Evidence from a Mendelian Randomization Study

Zhou,

Qi,

Cao

et al. 2024

IJMS

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A growing number of studies indicate that mitochondrial dysfunction serves as a pathological mechanism for periodontitis. Therefore, this two-sample Mendelian randomization (MR) study was carried out to explore the causal associations between mitochondrial biological function and periodontitis, because the specific nature of this causal relationship remains inconclusive in existing MR studies. Inverse variance weighting, Mendelian randomization-Egger, weighted mode, simple mode, and weighted median analyses were performed to assess the causal relationships between the exposure factors and periodontitis. The results of the present study revealed a causal association between periodontitis and medium-chain specific acyl-CoA dehydrogenase (MCAD), malonyl-CoA decarboxylase (MLYCD), glutaredoxin 2 (Grx2), oligoribonuclease (ORN), and pyruvate carboxylase (PC). Notably, MCAD and MLYCD are causally linked to periodontitis, and serve as protective factors. However, Grx2, ORN, and PC function as risk factors for periodontitis. Our study established a causal relationship between mitochondrial biological function and periodontitis, and such insights may provide a promising approach for treating periodontitis via mitochondrial regulation.

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Isobavachin attenuates osteoclastogenesis and periodontitis-induced bone loss by inhibiting cellular iron accumulation and mitochondrial biogenesis

Cited by 2 publications

References 78 publications

Mitochondria in skeletal system-related diseases

Mitochondria in skeletal system-related diseases

Causal Relationship between Mitochondrial Biological Function and Periodontitis: Evidence from a Mendelian Randomization Study

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