Isobornyl Acrylate and Diabetic Devices Steal the Show for the 2020 American Contact Dermatitis Society Allergen of the Year

Nath, Neel; Reeder, Margo J.; Atwater, Amber Reck

doi:10.12788/cutis.0014

Cited by 8 publications

(10 citation statements)

References 11 publications

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“…Irritant contact dermatitis (ICD) and ACD are common findings among patients with diabetes who use GS and CSII, 8,10–15 usually presenting as annular erythematous lesions at the sites where the device has been applied 7,10 . Compared to ACD, ICD usually has an earlier presentation of symptoms.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, patients undergo patch testing to identify the culprit of any ACD. However, this task is complicated by the fact that manufacturers do not need to disclose the chemical composition of their product 7,11 …”

Section: Introductionmentioning

confidence: 99%

“…8 A recent Danish report demonstrated ACD in 76.3% of patients referred for patch testing related to the use of GS and CSII. 9 Irritant contact dermatitis (ICD) and ACD are common findings among patients with diabetes who use GS and CSII, 8,[10][11][12][13][14][15] usually presenting as annular erythematous lesions at the sites where the device has been applied. 7,10 Compared to ACD, ICD usually has an earlier presentation of symptoms.…”

Section: Introductionmentioning

confidence: 99%

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Contact dermatitis in children caused by diabetes devices

et al. 2022

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Background: Insulin pumps and glucose monitoring devices improve diabetes mellitus control and enhance patients' quality of life. However, a growing number of adverse cutaneous reactions related to the use of these devices have been reported.Objective: To investigate the culprits of localized contact dermatitis in paediatric patients with diabetes caused by insulin pumps and glucose monitoring devices.Methods: Retrospective analysis of 15 paediatric patients patch tested as part of a clinical investigation for skin reactions associated with insulin pumps and glucose monitoring devices.Results: Seven patients had positive patch test reactions to isobornyl acrylate (IBOA) and five had positive reactions to benzoyl peroxide (BP). Positive patch test reactions to materials from the glucose sensor and/or insulin pump were seen in 10 of the 15 patients. Three had positive reactions to adhesive remover wipe from Smith and Nephew Remove and four had reactions to EMLA plaster. Conclusion:A high share of patients showed positive reactions to IBOA and/or their medical devices (insulin pumps or glucose devices). A third of patients showed positive reactions to BP. The presence of additional unidentified allergens cannot be excluded, highlighting the importance of access to a full description of the chemical composition of the devices.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Contact dermatitis in children caused by diabetes devices

et al. 2022

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mentioning

confidence: 99%

“…In recent years, a worldwide epidemic has emerged of cutaneous adverse events related to the use of medical devices (MDs) worn by people with diabetes. Numerous cases have been published regarding allergic contact dermatitis (ACD) caused by acrylates present in glucose sensors and insulin pumps, not only in adults [1][2][3] but also in the paediatric diabetic patient population. [4][5][6] The new glucose monitoring systems and insulin pumps are innovative instruments allowing patients with diabetes to optimize glycaemic control without the burden of repeated skin pricks.…”

mentioning

confidence: 99%

Time for a change

Agner

Goossens

2021

Br J Dermatol

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expression in skin fibroblasts. Chronic UVA exposure is responsible for most of the skin damage associated with photoageing, including specific histone acetylation changes. 6 Recent research has further confirmed that inhibition of histone deacetylases is an effective approach for modulating expression of this water channel protein. 7 More importantly, Xie et al. demonstrate that a short-term effect of chronic UVA (which is comparable with mild sun exposure) is increased autophagy activation and consequently reduced senescence in skin fibroblasts. Further research in keratinocyte lineages is needed to confirm this crucial concept, which would strengthen the beneficial role of autophagy in protection from skin photoageing. According to their model, increased AQP3 expression, transcriptionally regulated by Jun, facilitates the interaction of this channel protein with the scaffold protein DEDD (death effector domain-containing protein), which itself promotes autophagy activation via interaction with PI3KC3. 8 Although the dynamic described here is the opposite (AQP3 interaction leads to DEDD degradation, while still promoting autophagy), Xie et al. provide further evidence that AQP3 can bind and stimulate Beclin1, another key autophagy regulator.This study clearly shows that increased AQP3 expression attenuates long-term UVA-induced senescence in skin fibroblasts by promoting autophagy. This concept is reinforced by the evidence that treatment with rapamycin (an autophagy inducer) can ameliorate the aged phenotype in a UVA-induced skin photoageing mouse model. Overall, the mechanism presented here supports a recently described mouse model of Cockayne syndrome, a genetic disorder characterized by premature ageing where mice display accumulation of autophagy-related proteins and lysosomal dysfunction in their skin when exposed to UV light. 9 Histone deacetylase inhibition successfully prevented subcutaneous fat loss and rescued autophagic/lysosomal dysfunction. It would be interesting to explore whether changes in AQP3 expression could be involved in this mechanistic model too. In the meantime, we have learned from this study by Xie et al. that mild sun exposure can stimulate autophagy, maintaining healthy skin.

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The Skin in Diabetes

Yesudian

2024

Textbook of Diabetes

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Isobornyl Acrylate and Diabetic Devices Steal the Show for the 2020 American Contact Dermatitis Society Allergen of the Year

Cited by 8 publications

References 11 publications

Contact dermatitis in children caused by diabetes devices

Contact dermatitis in children caused by diabetes devices

Time for a change

The Skin in Diabetes

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