Isocorilagin, isolated from Canarium album (Lour.) Raeusch, as a potent neuraminidase inhibitor against influenza A virus

Chen, Fangzhao; Yang, Linjie; Huang, Yingna; Chen, Yun; Sang, Huiting; Duan, Wenjun; Yang, Jie

doi:10.1016/j.bbrc.2019.12.043

Cited by 20 publications

(12 citation statements)

References 22 publications

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“…-the mechanism inhibits viral replication or viral genome synthesis. HSV-1 employs glycosaminoglycan (GAG) as initial attachment receptors during infection of their host cell, so polyphenols target HSV-1 glyco-proteins -this type of interaction prevents the virus from connecting with binding receptors and cell surface [33] plant-based polyphenols tannic acid with modified silver nanoparticles (TA-AgNPs) HSV-2 5 µg/mouse TA-AgNPs sized 33 nm applied upon the mucosal tissue -the mechanism is based on two properties of used compounds -one is connected with tannic acid that interferes with the viral adsorption mechanism -second is based on the ability of silver nanoparticles that can block the attachment of the virus and its entry -nanoparticles can also induct antiviral cytokine and chemokine production -efficiency of TA-AgNPs of the inactivation of the virus might depend on the proline content in HSV glycoproteins [34] Arachis hypogaea (L.) skin, ethanol extract extract most probably consist of phenolic acids (coumaric, ferulic, chlorogenic, p-hydrobenzoic acids), phenolics (catechins, A-PACB-PAC), and stilbenes (resveratrol), where resveratrol is the main compound IAV, IBV IC50-1.0-1.5 µg/mL, CC50-5.4-9.1l µg/mL -the mechanism is probably based on inhibition of replication or its early stages, where a combination of an extract with oseltamivir and amantadine prove to be more effective against the influenza virus -this phenomenon is most probably due to targeting different phases of replication -polyphenols combined with the amino acids contained in S-glycoprotein, ACE2, furin, TMPRSS2 using mainly hydrogen bonds -in punicalagin and punicalin, there are 3-4 hydrogen bonds, and also Pi-alkyl, Pi-Pi bonds are present, which stabilizes the complex IAV variety (H1N1) CC50-0.90 ± 0.01 µg/mL IC50-0.30 ± 0.02 µg/mL -the inhibition of the influenza virus is accomplished through the suppression of the HA -MF1 fraction acts at the HA level and thus prevents the virus from binding to the cell surface receptors [87] Table 1. Cont.…”

Section: Mechanism Of Antiviral Activitymentioning

confidence: 99%

Antiviral Properties of Polyphenols from Plants

Chojnacka

Skrzypczak

Izydorczyk

et al. 2021

Foods

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Polyphenols are active substances against various types of viral infections. Researchers have characterized methods of how to isolate polyphenols without losing their potential to formulate pharmaceutical products. Researchers have also described mechanisms against common viral infections (i.e., influenza, herpes, hepatitis, rotavirus, coronavirus). Particular compounds have been discussed together with the plants in the biomass in which they occur. Quercetin, gallic acid and epigallocatechin are exemplary compounds that inhibit the growth cycle of viruses. Special attention has been paid to identify plants and polyphenols that can be efficient against coronavirus infections. It has been proven that polyphenols present in the diet and in pharmaceuticals protect us from viral infections and, in case of infection, support the healing process by various mechanisms, i.e., they block the entry into the host cells, inhibit the multiplication of the virus, seal blood vessels and protect against superinfection.

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Section: Mechanism Of Antiviral Activitymentioning

confidence: 99%

Antiviral Properties of Polyphenols from Plants

Chojnacka

Skrzypczak

Izydorczyk

et al. 2021

Foods

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“…DC. derived isocorilagin, a polyphenolic compound, showed an antiviral activity against diverse influenza A strains by targeting NA with low cytotoxic effects against host cells ( Chen et al, 2020 ). Furthermore, Canarium album (Lour.)…”

Section: Natural Products With Reported Activities Against Viral Pneumonia: Focus On Medicinal Plantsmentioning

confidence: 99%

Overview of Viral Pneumonia Associated With Influenza Virus, Respiratory Syncytial Virus, and Coronavirus, and Therapeutics Based on Natural Products of Medicinal Plants

Lin

Chen

et al. 2021

Front. Pharmacol.

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Viral pneumonia has been a serious threat to global health, especially now we have dramatic challenges such as the COVID-19 pandemic. Approximately six million cases of community-acquired pneumonia occur every year, and over 20% of which need hospital admission. Influenza virus, respiratory virus, and coronavirus are the noteworthy causative agents to be investigated based on recent clinical research. Currently, anaphylactic reaction and inflammation induced by antiviral immunity can be incriminated as causative factors for clinicopathological symptoms of viral pneumonia. In this article, we illustrate the structure and related infection mechanisms of these viruses and the current status of antiviral therapies. Owing to a set of antiviral regiments with unsatisfactory clinical effects resulting from side effects, genetic mutation, and growing incidence of resistance, much attention has been paid on medicinal plants as a natural source of antiviral agents. Previous research mainly referred to herbal medicines and plant extracts with curative effects on viral infection models of influenza virus, respiratory virus, and coronavirus. This review summarizes the results of antiviral activities of various medicinal plants and their isolated substances, exclusively focusing on natural products for the treatment of the three types of pathogens that elicit pneumonia. Furthermore, we have introduced several useful screening tools to develop antiviral lead compounds.

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“…Yang et al obtained ten known metabolite compounds, such as ellagic acid, gallic acid, and scopolamine, from C. album fruits by using repeated chromatography [ 12 ]. Chen et al isolated isocorilagin and methyl brevifolincarboxylate from C. album [ 13 , 14 ]. It should be noted that the metabolite type and content differences in fruits from different cultivars greatly influence their functional activities [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Integrated Metabolomic and Transcriptomic Analysis Reveals Differential Flavonoid Accumulation and Its Underlying Mechanism in Fruits of Distinct Canarium album Cultivars

Lai

Shen

Feng

et al. 2022

Foods

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Canarium album fruit has great potential to be consumed as a raw material not only for food but also medicine. The diverse active metabolites composition and content of C. album fruits greatly affect their pharmacological effects. However, up to now, there has been no report on the global metabolome differences among fruits from distinct C. album cultivars. In our present study, by using non-targeted metabolomics techniques, we identified 87 DAMs (differentially accumulated metabolites) including 17 types of flavonoids from fruits of four different C. album cultivars. KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment analysis revealed that the flavone and flavonol biosynthesis- and flavonoid biosynthesis-related DAMs were major factors determining their metabolome differences. Comparative transcriptomic analysis revealed that 15 KEGG pathways were significantly enriched by genes of the identified 3655 DEGs (differentially expressed genes) among different C. album cultivars. Consistent with the metabolome data, flavonoid biosynthesis-related DEGs, including eight key structural genes (such as FLS, CCoAOMT, CHI, C4H, DFR, LAR, and C3′H, etc.) and several regulatory transcription factor (TF) genes (including 32 MYBs and 34 bHLHs, etc.), were found to be significantly enriched (p < 0.01). Our study indicated that the differential expression of flavonoid biosynthesis-related genes and accumulation of flavonoids played dominant roles in the various metabolome compositions of fruits from different C. album cultivars.

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Isocorilagin, isolated from Canarium album (Lour.) Raeusch, as a potent neuraminidase inhibitor against influenza A virus

Cited by 20 publications

References 22 publications

Antiviral Properties of Polyphenols from Plants

Antiviral Properties of Polyphenols from Plants

Overview of Viral Pneumonia Associated With Influenza Virus, Respiratory Syncytial Virus, and Coronavirus, and Therapeutics Based on Natural Products of Medicinal Plants

Integrated Metabolomic and Transcriptomic Analysis Reveals Differential Flavonoid Accumulation and Its Underlying Mechanism in Fruits of Distinct Canarium album Cultivars

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