2010
DOI: 10.1002/ange.201000723
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Isocyanide in der Synthese von Stickstoff‐Heterocyclen

Abstract: Isocyanide bewähren sich seit langem als unersetzliche Bausteine in der modernen organischen Chemie. Die einzigartigen Eigenschaften der Isocyanogruppe machen Isocyanide für die Synthese etlicher wichtiger Klassen von Stickstoff‐Heterocyclen wie Pyrrolen, Indolen oder Chinolinen besonders wertvoll. In letzter Zeit wurde eine ganze Reihe von Cocyclisierungen von Isocyaniden über Zwitterionen und radikalische Intermediate ebenso wie übergangsmetallkatalysierte Synthesen verschiedener Arten von Heterocyclen entwi… Show more

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Cited by 108 publications
(21 citation statements)
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References 248 publications
(163 reference statements)
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“…Since the Ugi reaction wasr eported, [20] extensives tudies have been carriedo ut to utilize isocyanides in organic synthesis, such as heterocycle synthesis. [21] Recently we developed am ethod for 1,4-diarylimidazole synthesis [22] based on Cu-catalyzedf ormimidate formation from isocyanides. [23] Thus,w e envisioned an ovel strategy for the synthesis of b-enaminonitriles from isocyanides as the nitrogen source [Scheme 2, Eq.…”
Section: Introductionmentioning
confidence: 99%
“…Since the Ugi reaction wasr eported, [20] extensives tudies have been carriedo ut to utilize isocyanides in organic synthesis, such as heterocycle synthesis. [21] Recently we developed am ethod for 1,4-diarylimidazole synthesis [22] based on Cu-catalyzedf ormimidate formation from isocyanides. [23] Thus,w e envisioned an ovel strategy for the synthesis of b-enaminonitriles from isocyanides as the nitrogen source [Scheme 2, Eq.…”
Section: Introductionmentioning
confidence: 99%
“…Isocyanides are uniquely versatile building blocks, which could directly construct heterocycles with high efficiency. [5] Recently, the radical initiated insertion/cyclization of aryl isocyanides has emerged as a powerful strategy for the construction of various heteroarenes, where an isocyano group is well established as the radical acceptor. [6] Along these lines, our group have disclosed that aromatic isocyanides can be used as highly efficient alkyl radical acceptors for preparation of multi-substituted phenanthridines.…”
Section: Introductionmentioning
confidence: 99%
“…[3] The synthesis of isonitriles has blossomed because isonitriles provide a rapid entry into drug-like molecules, heterocycles, [4] and diverse molecular scaffolds. [5] …”
Section: Introductionmentioning
confidence: 99%