Isoenzymes of creatine phosphokinase in tissue extracts and in normal and pathological sera

Veen, K.J. Van Der; Willebrands, A. F.

doi:10.1016/0009-8981(66)90209-9

Cited by 183 publications

(39 citation statements)

References 5 publications

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“…CK was shown to exist in three molecular forms MM, MB, and BB. In 1996, van der Ween and Willebrands (10 ) showed that MBCK is a highly specific marker of myocardial infarction. The CK content of myocardial tissue was shown to be ϳ15% MB and the remainder MMCK (11 ).…”

Section: Historical Perspectivementioning

confidence: 99%

Cardiac Biomarkers for Detection of Myocardial Infarction: Perspectives from Past to Present

et al. 2004

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Editor’s Note: With great pleasure and anticipation in recognition of Clinical Chemistry’s 50th anniversary, I have been able to arm-twist four talented scientists to document their impressive marks on the science of diagnostics in the field of cardiac biomarkers and detection of myocardial infarction. Their exciting discoveries and applications have dramatically influenced the fields of laboratory medicine and cardiology and have greatly influenced the care and management of thousands of patients suffering from coronary artery disease leading to acute myocardial infarction. As a matter of historical record, I owe a great deal of thanks to each one of the coauthors of this special report because each one has personally influenced my scientific career. I met Dr. Rosalki, during my postdoctoral training, at a national AACC meeting, where he kindly answered my numerous queries regarding creatine kinase enzymology and muscle physiology. Dr. Roberts, while serving as Director of the Coronary Care Unit at Washington University in St. Louis, generously allowed this fledgling fellow into his laboratory and shared many of his clinical and experimental findings with me. Dr. Katus, whom I first met at a scientific meeting sponsored by Boehringer Mannheim in 1986 in Bavaria, where I first became fascinated with cardiac troponin T, has remained a friend and colleague. Lastly, Dr. Ladenson, who as mentor, scientific colleague, and close friend remains ultimately responsible for both my professional growth as a clinical chemist (he was my postdoctoral fellowship advisor) and for stimulating and encouraging my goals and aspirations in the field of cardiac biomarkers. With the descriptions of the ground-breaking science described below, I am extremely excited and optimistic that the future of cardiac biomarkers is secure and open to new discoveries by the Rosalkis, Robertses, Katuses, and Ladensons of the future. —Fred Apple

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Section: Historical Perspectivementioning

confidence: 99%

Cardiac Biomarkers for Detection of Myocardial Infarction: Perspectives from Past to Present

et al. 2004

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“…Serum CK and LDH are generally known as accurate indicators of muscle damage (Coombes and McNaughton, 2000). CK is present in both skeletal and cardiac muscle and it is released into the blood when myocyte necrosis occurs (Bessman and Carpenter, 1985;Van der Veen and Willebrands, 1966). LDH catalyzes the interconversion of pyruvate and lactate (Vasudevan et al, 1978).…”

Section: Discussionmentioning

confidence: 99%

Sogeunjung-tang improves depressive-like behavior decreased by forced-swimming test

Jeong¹,

Moon²,

Kim³

et al. 2017

TANG [HUMANITAS MEDICINE]

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Sogeunjung-tang (S-tang) is a traditional Korean medicine that has been used for the therapy of anxiety disorder in a variety of clinical situations. However, no study has investigated this effect. The aim of this study was to investigate the effectiveness of S-tang for reducing depression in animal model. The antidepressant effect of S-tang was investigated in ICR mice by using forced swimming test (FST). After FST, we analyzed the blood biochemical parameters from blood. The immobility time was significantly decreased in the S-tang oral administration or pharmaceutical acupuncture group compared with the control group at 14 days (p < 0.05). The anti-depressant effect of S-tang was higher than that of fluoxetine (a classical anti-depressant). S-tang or fluoxetine significantly decreased the creatine kinase and lactate dehydrogenase level compared with the control group (p < 0.05) but not glucose, protein, and blood urea nitrogen level. Further investigation of S-tang as a potential pharmacologic agent in the management of depression related anxiety is warranted.

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“…Creatinine kinase (CK) and its isoenzyme MB (CK-MB) were the first markers of injury described in the 1960s in myocardial infarction 6 . It has been demonstrated that creatinine kinase isoenzyme MB had greater sensitivity and specificity, and therefore it became the gold standard in the evaluation of ischemic injury.…”

Section: Objective -To Verify the Association Of Serum Markers Of Myomentioning

confidence: 99%

Behavior of inflammatory markers of myocardial injury in cardiac surgery: laboratory correlation with the clinical picture of postpericardiotomy syndrome

Köhler¹,

Saraiva²,

Wender³

et al. 2003

Arq. Bras. Cardiol.

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OBJECTIVE: To verify the association of serum markers of myocardial injury, such as troponin I, creatinine kinase, and creatinine kinase isoenzyme MB, and inflammatory markers, such as tumor necrosis factor alpha (TNF-alpha), C-reactive protein, and the erythrocyte sedimentation rate in the perioperative period of cardiac surgery, with the occurrence of possible postpericardiotomy syndrome. METHODS: This was a cohort study with 96 patients undergoing cardiac surgery assessed at the following 4 different time periods: the day before surgery (D0); the 3rd postoperative day (D3); between the 7th and 10th postoperative days (D7-10); and the 30th postoperative day (D30). During each period, we evaluated demographic variables (sex and age), surgical variables (type and duration , extracorporeal circulation), and serum dosages of the markers of myocardial injury and inflammatory response. RESULTS: Of all patients, 12 (12.5%) met the clinical criteria for a diagnosis of postpericardiotomy syndrome, and their mean age was 10.3 years lower than the age of the others (P=0.02). The results of the serum markers for tissue injury and inflammatory response were not significantly different between the 2 assessed groups. No significant difference existed regarding either surgery duration or extracorporeal circulation. CONCLUSION: The patients who met the clinical criteria for postpericardiotomy syndrome were significantly younger than the others were. Serum markers for tissue injury and inflammatory response were not different in the clinically affected group, and did not correlate with the different types and duration of surgery or with extracorporeal circulation

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Isoenzymes of creatine phosphokinase in tissue extracts and in normal and pathological sera

Cited by 183 publications

References 5 publications

Cardiac Biomarkers for Detection of Myocardial Infarction: Perspectives from Past to Present

Cardiac Biomarkers for Detection of Myocardial Infarction: Perspectives from Past to Present

Sogeunjung-tang improves depressive-like behavior decreased by forced-swimming test

Behavior of inflammatory markers of myocardial injury in cardiac surgery: laboratory correlation with the clinical picture of postpericardiotomy syndrome

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