Isoflavones

Křížová, Ludmila; Dadáková, Kateřina; Kašparovská, Jitka; Kašparovský, Tomáš

doi:10.3390/molecules24061076

Cited by 531 publications

(453 citation statements)

References 243 publications

(357 reference statements)

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“…To the fact that identification of all aspects of molecular mechanisms of isoflavones present in legumes influence on mineralization is quite complicated, for the beginning we chose isoflavones interactions with RANKL and their possible influence on functional mineralization process in Saos-2 cells. The mechanism of isoflavones effect on osteoclasts probably does not depend on estrogen mechanisms, as there are no ERs in the osteoclast nuclei [25]. Presented results are necessary and basal for our further studies and they do not exclude involvement of different types of signaling transduction pathways.…”

Section: Effect Of Isoflavones On Saos-2 Viability and Mineralizationmentioning

confidence: 81%

“…Intake of biochanin A in foods is additionally supported by the fact that biochanin A blood level has been shown to be higher when consumed in the presence of other isoflavones [24]. Intake of isoflavones may be particularly beneficial in preventing osteoporosis when they are additionally accompanied by proteins of both plant and animal origin [25]. Numerous previous studies have indicated that soybean, the most commonly consumed legume rich in phytoestrogens such as genistein and daidzein glycosides, has osteogenic activity.…”

Section: Energetic Effects Of Rankl-isoflavones Interactionsmentioning

confidence: 99%

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Evaluation of Isoflavones as Bone Resorption Inhibitors upon Interactions with Receptor Activator of Nuclear Factor-κB Ligand (RANKL)

et al. 2020

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Receptor activator of nuclear factor-κB ligand (RANKL) is a cytokine responsible for bone resorption. It binds its receptor RANK, which activates osteoporosis. High levels of osteoprotegerin (OPG) competitively binding RANKL limit formation of ligand-receptor complexes and enable bone mass maintenance. The new approach to prevent osteoporosis is searching for therapeutics that can bind RANKL and support OPG function. The aim of the study was to verify the hypothesis that isoflavones can form complexes with RANKL limiting binding of the cytokine to its receptor. Interactions of five isoflavones with RANKL were investigated by isothermal titration calorimetry (ITC), by in silico docking simulation and on Saos-2 cells. Daidzein and biochanin A showed the highest affinity for RANKL. Among studied isoflavones coumestrol, formononetin and biochanin A showed the highest potential for Saos-2 mineralization and were able to regulate the expression of RANKL and OPG at the mRNA levels, as well as osteogenic differentiation markers: alkaline phosphatase (ALP), collagen type 1, and Runt-related transcription factor 2 (Runx2). Comparison of the osteogenic activities of isoflavones showed that the use of physicochemical techniques such as ITC or in silico docking are good tools for the initial selection of substances showing a specific bioactivity.

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Section: Effect Of Isoflavones On Saos-2 Viability and Mineralizationmentioning

confidence: 81%

Section: Energetic Effects Of Rankl-isoflavones Interactionsmentioning

confidence: 99%

Evaluation of Isoflavones as Bone Resorption Inhibitors upon Interactions with Receptor Activator of Nuclear Factor-κB Ligand (RANKL)

et al. 2020

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“…Daidzein, a natural compound easily found in soybeans and a number of plants, has been reported for its pharmacological activity in the prevention and therapy of cardiovascular disease, several types of cancer, osteoporosis and menopausal symptoms [88]. Due to its low water solubility and first-pass metabolism, daidzein shows poor oral BA [89].…”

Section: Daidzeinmentioning

confidence: 99%

Liposomes for Enhanced Bioavailability of Water-Insoluble Drugs: In Vivo Evidence and Recent Approaches

Lee

2020

Pharmaceutics

187

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It has been known that a considerable number of drugs in clinical use or under development are water-insoluble drugs with poor bioavailability (BA). The liposomal delivery system has drawn attention as one of the noteworthy approaches to increase dissolution and subsequently absorption in the gastrointestinal (GI) tract because of its biocompatibility and ability to encapsulate hydrophobic molecules in the lipid domain. However, there have been several drawbacks, such as structural instability in the GI tract and poor permeability across intestinal epithelia because of its relatively large size. In addition, there have been no liposomal formulations approved for oral use to date, despite the success of parenteral liposomes. Nevertheless, liposomal oral delivery has resurged with the rapid increase of published studies in the last decade. However, it is discouraging that most of this research has been in vitro studies only and there have not been many water-insoluble drugs with in vivo data. The present review focused on the in vivo evidence for the improved BA of water-insoluble drugs using liposomes to resolve doubts raised concerning liposomal oral delivery and attempted to provide insight by highlighting the approaches used for in vivo achievements.Pharmaceutics 2020, 12, 264 2 of 30 However, there have been several drawbacks to be overcome, such as instability in the GI tract and poor permeability across the intestinal epithelia because of liposomes' relatively large size [8]. Moreover, it seemed that liposomal oral delivery was faltering during 1980s due to some disappointing results for insulin [9]. However, liposomal oral delivery resurged with a rapid increase in the number of papers published, as shown in Pubmed search results, mainly due to various advanced modification technologies, even though liposomal oral delivery-related papers account for only 5-6% of the total number of liposomes-related studies (Figure 1). In addition, there was an encouraging meta-analysis report in which phospholipid-based solid formulations were analyzed as being effective for BA enhancement [10]. Although liposomal delivery does not seem to achieve satisfactory improvement of oral BA for peptides and protein drugs yet, it looks more promising for oral delivery of hydrophobic drugs because liposomes can solubilize poorly water-soluble drugs, protect the drug from degradation in the GI tract and enhance permeability through the epithelial cell membrane, consequently increasing oral BA. However, most published papers performed in vitro studies only, thus lacking in vivo pharmacokinetic results. The present review focuses on the in vivo evidence for the improved BA of water-insoluble drugs and highlights the approaches used for in vivo achievements.

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“…From a molecular standpoint, genistein seems to exert pleiotropic effects, being able to activate various DNA damage checkpoints, promoting cell cycle arrest, mitotic catastrophe and cell death (depleting G1 population of cells, leading to an accumulation at G2/M and activating the apoptotic cascades, up-regulating caspase-3 and caspase-7 as well as p38/MAPK and ATM/Chk2/Cdc25C/Cdc2, and down-regulating the Bcl-2-Bax and NF-κB/p65 complexes) [53][54][55]. Furthermore, genistein finely tunes different angiogenetic cascades [56,57].…”

Section: Brca1 Diet and Breast Cancermentioning

confidence: 99%

Nutrigenomics and Breast Cancer: State-of-Art, Future Perspectives and Insights for Prevention

Sellami

Bragazzi

2020

Nutrients

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Proper nutrition plays a major role in preventing diseases and, therefore, nutritional interventions constitute crucial strategies in the field of Public Health. Nutrigenomics and nutriproteomics are arising from the integration of nutritional, genomics and proteomics specialties in the era of postgenomics medicine. In particular, nutrigenomics and nutriproteomics focus on the interaction between nutrients and the human genome and proteome, respectively, providing insights into the role of diet in carcinogenesis. Further omics disciplines, like metabonomics, interactomics and microbiomics, are expected to provide a better understanding of nutrition and its underlying factors. These fields represent an unprecedented opportunity for the development of personalized diets in women at risk of developing breast cancer.

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Isoflavones

Cited by 531 publications

References 243 publications

Evaluation of Isoflavones as Bone Resorption Inhibitors upon Interactions with Receptor Activator of Nuclear Factor-κB Ligand (RANKL)

Evaluation of Isoflavones as Bone Resorption Inhibitors upon Interactions with Receptor Activator of Nuclear Factor-κB Ligand (RANKL)

Liposomes for Enhanced Bioavailability of Water-Insoluble Drugs: In Vivo Evidence and Recent Approaches

Nutrigenomics and Breast Cancer: State-of-Art, Future Perspectives and Insights for Prevention

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