Isoflavones improve collagen I and glycosaminoglycans and prevent bone loss in type 1 diabetic rats

Carbonel, Adriana Aparecida Ferraz; Vieira, M.; Simões, Ricardo Santos; Lima, Patrícia; Fuchs, Luiz Fernando Portugal; Girão, Eduardo R C; Cicivizzo, G. P.; Sasso, Gisela Rodrigues da Silva; Moraes, Luís Otávio Carvalho de; Soares, José Maria; Baracat, Edmund Chada; Simões, Manuel J.; Girão, Manoel Joâo Batista Castello

doi:10.1080/13697137.2019.1627314

Cited by 5 publications

(3 citation statements)

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“…In addition, work from the lab demonstrated beneficial effects on diabetic conditions and in obese animals [12][13][14]. We previously demonstrated that isoflavone protects from kidney injury in obese animals via PPAR-γ [14], prevents bone loss in ovariectomized diabetic animals [15], and can attenuate the effects of vulvovaginal atrophy in women [16]. Taking into account the protective function of PPAR-γ in kidney injury [17][18][19][20], the objective of this work was to evaluate the effect of ovariectomy and the consequent gonadal failure on the development of DM1induced kidney injury, as well as the contribution of soy isoflavone via PPAR-γ in this experimental animal model.…”

Section: Introductionmentioning

confidence: 97%

Isoflavone Protects the Renal Tissue of Diabetic Ovariectomized Rats via PPARγ

et al. 2022

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Diabetes associated with post-menopause is related to a worse condition of kidney disease. Taking into consideration that this disorder may be regulated by estrogenic mediators, we evaluated the renal protective effect of isoflavone. We investigated the role of the PPARγ in the pathogenesis of the disease. For this study, we used diabetic female rats in a postmenopausal model through ovariectomy. The animals were treated with isoflavone or 17β-estradiol. A dosage was administered to bring on blood glycemia, and through immunohistochemistry, we evaluated the immunoreactivity of PPARγ in the endometrium and renal tissue. We analyzed the immunoreactivity of renal injury molecule KIM-1 and the collagen and glycogen densities in the kidney. Through bioinformatics analysis, we observed PPARγ and COL1A1 gene expression under the influence of different glucose doses. In particular, we observed that isoflavone and 17β-estradiol regulate blood glycemia. Renal injury was inhibited by isoflavone, observed by a reduction in KIM-1, along with glycogen accumulation. These benefits of isoflavone may be associated with PPARγ overexpression in the kidneys and endometrium of diabetic ovariectomized rats.

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Section: Introductionmentioning

confidence: 97%

Isoflavone Protects the Renal Tissue of Diabetic Ovariectomized Rats via PPARγ

et al. 2022

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“…Descobrindo e Construindo Sobral: Conhecimentos de Geografia eHistória (2002), este último adotado naquele ano pelas escolas mantidas pelo município, obras em que a professora Giovana figurava como autora e que apresentavam o MDJ como símbolo do "pioneirismo e distinção da cidade comparada às demais no âmbito cearense"30 . Assim como o museu, as referidas publicações reforçavam a ideia da distinção da cidade por ter se originado quase que exclusivamente da colonização portuguesa31 , ao afirmarem a exceção de Sobral em possuir essa característica 32 . Função Educativa dos Museus].…”

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