Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata

Cudrania tricuspidata: an updated review on ethnomedicine, phytochemistry and pharmacology

“…20,21 Xanthones and avonoids have been considered to be the two major classes of phytochemicals in C. tricuspidata. For example, prenylated xanthones and avonoids were found to be the most important and abundant constituents in its leaves and root bark with regard to their notable anti-inammatory, 22,23 antitumor, 16,24 hepatoprotective, 25,26 neuroprotective, 27,28 and anticoagulant 29 activities; hydroxybenzyl avonoid glycosides from the stem bark were reported to be promising natural antioxidant and antitumor agents; 30 and prenylated isoavonoids and benzylated avonoids from the fruits displayed potential anti-inammatory 31 and antioxidant 32 activities. Besides, a glycoprotein (75 kDa) from C. tricuspidata, which consisted of carbohydrate (72.5%) and protein moieties (27.5%), exhibited distinctive characteristics with anti-inammatory, 33 antioxidant, 34 hepatoprotective, 35 and immunomodulatory 36 effects.…”

Polysubstituted Isoflavonoids from Spatholobus suberectus, Flemingia macrophylla, and Cudrania cochinchinensis

“…for C 22 H 23 O 7 , 399.1444). The NMR spectra (Table 4) showed an olefinic signal ( δ H 8.23, 1H, s; δ C 154.3, d) and a chelated hydroxy group at δ H 13.48 (1H, s), characteristic of a 5-hydroxyisoflavone skeleton [8, 13]. In addition, an ABX-type aromatic proton system [ δ H 7.15 (1H, d, J  = 2.0 Hz), 6.86 (1H, d, J  = 8.2 Hz), and 6.94 (1H, dd, J  = 8.2, 2.0 Hz)], a prenyl group [ δ H 1.63, 1.79 (each 3H, s), 3.45 (2H, d, J  = 7.1 Hz), and 5.22 (1H, br t, J  = 7.1 Hz)], and a hydroxyethyl moiety [ δ H 2.97, 3.90 (each 2H, t, J  = 5.2 Hz)] were also detected in the 1 H NMR spectrum.…”

“…An overwhelming number of isoflavonoids reported come from the Leguminosae family, and some non-leguminous families such as Moraceae are also relatively abundant in isoflavonoids [1, 2]. Some isoflavans and prenylated isoflavones possess potent biological activities, especially in cytotoxicity [3–6], anti-inflammatory [7], and neuroprotective activity [8]. As part of a BioBioPha (http://www.chemlib.cn) objective to assemble a large-scale natural product library valuable in the discovery of new drug leads from nature [9–12], the phytochemical investigations on Spatholobus suberectus (Leguminosae), Flemingia macrophylla (Leguminosae), and Cudrania cochinchinensis (Moraceae) led to the isolation of three new isoflavans 7,4′-dihydroxy-8,2′,3′-trimethoxyisoflavan ( 1 ), 7,2′,4′-trihydroxy-8,3′-dimethoxyisoflavan ( 2 ), and 7,2′,4′-trihydroxy-5-methoxyisoflavan ( 3 ), and one new prenylated isoflavone namely cudraisoflavone M ( 4 ), respectively (Fig.…”

Scandenolone from Cudrania tricuspidata fruit extract suppresses the viability of breast cancer cells (MCF-7) in vitro and in vivo

“…Notably, the wild C. tricuspidata fruit is a red and edible berry ( Fig. 1), which contains several bioactive compounds (Hiep et al, 2015). C. tricuspidata extract has been reported to possess antioxidant activity and inhibitory effects on nitric oxide synthase (Xin et al, 2017).…”