Isoflavonoids from Sophora tonkinensis

Yang, Ronghua; Lan, Yan-Su; Zhong-jing, Huang; Shao, Chang‐Lun; Liang, Hong; Chen, Zhengfeng; Li, Jun

doi:10.1007/s10600-012-0345-7

Cited by 20 publications

(12 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The signals resonating at δ H 5.96 (d, J = 2.3 Hz) and 6.81 (d, J = 10.1 Hz) was identify as kaempferol 7‐(6″‐ p ‐coumarylglucoside) ( 35 ) 37 . As for the isoflavones group, daidzein ( 22 ) was identify based on the signals at δ H 7.95 (d, J = 8.1 Hz), 7.32 (d, J = 7.4 Hz) and 6.85 (m), 26 while the signals at δ H 6.85 (m), 6.88 (d, J = 2.0 Hz) and 7.04 (d, J = 1.6 Hz) were assigned for 3′‐hydroxydaidzein ( 25 ) 29 . The signals corresponding to 2′,4′,7‐trihydroxy‐3′,8‐diprenylisoflavan ( 28 ) were detected at δ H 1.75 (s), 2.54 (dd, J = 3.8, 15.8 Hz), 3.19 (d, J = 8.9 Hz) and 5.25 (t, J = 6.5 Hz) 32 .…”

Section: Resultsmentioning

confidence: 99%

Metabolite variations and antioxidant activity of Muntingia calabura leaves in response to different drying methods and ethanol ratios elucidated by NMR‐based metabolomics

Zolkeflee

Isamail

Maulidiani

et al. 2020

Phytochemical Analysis

View full text Add to dashboard Cite

Introduction Muntingia calabura from the Muntingiaceae family has been documented for several medicinal uses. The combinations of drying treatment and extracting solvents for a plant species need to be determined and optimised to ensure that the extracts contain adequate amounts of the bioactive metabolites. Objective Evaluate the metabolite variations and antioxidant activity among M. calabura leaves subjected to different drying methods and extracted with different ethanol ratios using proton nuclear magnetic resonance (1H‐NMR)‐based metabolomics. Methodology The antioxidant activity of M. calabura leaves dried with three different drying methods and extracted with three different ethanol ratios was determined by using 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) and nitric oxide (NO) scavenging assays. The metabolites variation among the extracts and correlation with antioxidant activity were analysed by 1H‐NMR‐based metabolomics. Results Muntingia calabura leaves extracted with 50% and 100% ethanol from air‐drying and freeze‐drying methods had the highest total phenolic content and the lowest IC50 value for the DPPH scavenging activity. Meanwhile, oven‐dried leaves extracted with 100% ethanol had the lowest IC50 value for the NO scavenging activity. A total of 43 metabolites, including sugars, organic acids, amino acids, phytosterols, phenolics and terpene glycoside were tentatively identified. A noticeable discrimination was observed in the different ethanol ratios by the principal component analysis. The partial least‐squares analysis suggested that 32 compounds out of 43 compounds identified were the contributors to the bioactivities. Conclusion The results established set the preliminary steps towards developing this plant into a high value product for phytomedicinal preparations.

show abstract

Section: Resultsmentioning

confidence: 99%

Metabolite variations and antioxidant activity of Muntingia calabura leaves in response to different drying methods and ethanol ratios elucidated by NMR‐based metabolomics

Zolkeflee

Isamail

Maulidiani

et al. 2020

Phytochemical Analysis

View full text Add to dashboard Cite

show abstract

“…Butesuperins A ( 1 ) and B ( 2 ) have been considered to be marker compounds for Butea superba tubers because both of these compounds have been reportedly identified only in this plant. Recently, butesuperin A ( 1 ) was also isolated in Sophora tonkinensis . Not only butesuperin A but also butesuperin B should thus be detected in dietary supplements to confirm contamination of dietary supplements with Butea superba tubers.…”

Section: Methodsmentioning

confidence: 99%

“…9 A number of oxidants have been examined for the regio-and stereoselective construction of 1,4benzodioxane systems via oxidative coupling including AgO, 10,11 Ag 2 CO 3 , 12 TiO 2 , 13 AgNO 3, 14 K 3 Fe(CN) 6,15 and horseradish peroxidase with hydrogen peroxide. Our synthesis began with the preparation of isoflavone 5, coniferyl alcohol (8), and sinapyl alcohol (9), as illustrated in Scheme 1. Our synthesis began with the preparation of isoflavone 5, coniferyl alcohol (8), and sinapyl alcohol (9), as illustrated in Scheme 1.…”

mentioning

confidence: 99%

“…Our synthesis began with the preparation of isoflavone 5, coniferyl alcohol (8), and sinapyl alcohol (9), as illustrated in Scheme 1. 19 With both isoflavone 5 and coniferyl alcohol (8) in hand, their assembly was examined under a number of conditions (Scheme 2 and Table 1). 19 With both isoflavone 5 and coniferyl alcohol (8) in hand, their assembly was examined under a number of conditions (Scheme 2 and Table 1).…”

mentioning

confidence: 99%

See 1 more Smart Citation

First Syntheses of (±)‐Butesuperins A and B

Ganganna

Hwang

et al. 2017

Bulletin Korean Chem Soc

View full text Add to dashboard Cite

“…In China, S. tonkinensis has been used as folk medicine to treat sore throat, acute pharyngolaryngeal infection, asthma, jaundice, and allergic dermatitis for hundreds of years [1,2]. Phytochemical investigations have shown that S. tonkinensis is rich in flavonoids [3,4,5,6,7,8], quinolizidine alkaloids [9,10,11], and arylbenzofurans [12,13]. Recent pharmacological studies have indicated that the flavonoids from S. tonkinensis showed pretty good anti-inflammatory [14,15,16], neuroprotective [17], hypoglycemic [18], anti-tumor [8,10], anti-allergic [12], and antioxidant [13] activities.…”

Section: Introductionmentioning

confidence: 99%

Preparative Purification of Total Flavonoids from Sophora tonkinensis Gagnep. by Macroporous Resin Column Chromatography and Comparative Analysis of Flavonoid Profiles by HPLC-PAD

Hou

Xiu

et al. 2019

Molecules

View full text Add to dashboard Cite

For the full development and utilization of Sophora tonkinensis Gagnep., this study was primarily intended to established a simple and efficient approach for the preparative purification of total flavonoids from S. tonkinensis by macroporous resin column chromatography (MRCC). The adsorption and desorption characteristics of the total flavonoids on ten macroporous resins were first studied, and AB-8 resin was chosen as the most suitable, and the adsorption data were best fitted to the pseudo-second-order kinetics model and Langmuir isotherm model. Furthermore, the technological parameters for the purification of the total flavonoids were optimized using column chromatography. After a sample one-step purification procedure, the content of the total flavonoids increased by about 4.76-fold from 12.14% to 57.82%, with a recovery yield of 84.93%. In addition, the comparative analysis of the flavonoid extracts before and after purification was performed by high-performance liquid chromatography coupled with photodiode-array detection (HPLC-PAD). The results showed that the contents of six major flavonoids in the purified product were all higher than before the purification. Therefore, the AB-8 MRCC established in this work was a promising method for the industrial-scale purification of the total flavonoids from S. tonkinensis.

show abstract

Isoflavonoids from Sophora tonkinensis

Cited by 20 publications

References 12 publications

Metabolite variations and antioxidant activity of Muntingia calabura leaves in response to different drying methods and ethanol ratios elucidated by NMR‐based metabolomics

Metabolite variations and antioxidant activity of Muntingia calabura leaves in response to different drying methods and ethanol ratios elucidated by NMR‐based metabolomics

First Syntheses of (±)‐Butesuperins A and B

Preparative Purification of Total Flavonoids from Sophora tonkinensis Gagnep. by Macroporous Resin Column Chromatography and Comparative Analysis of Flavonoid Profiles by HPLC-PAD

Contact Info

Product

Resources

About