2022
DOI: 10.1177/10915818221084906
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Isoflurane Promotes Cell Proliferation, Invasion, and Migration by Regulating BACH1 and miR-375 in Prostate Cancer Cells In Vitro

Abstract: The aim of this study was to investigate the mechanism of isoflurane in proliferation, invasion, and migration in prostate cancer (PC) cells in vitro by regulating BACH1 and miR-375. The effect of different concentrations of isoflurane (0%, 0.5%, 1%, and 2%) on PC cell proliferation (PC3 and 22RV1) was measured. After PC cells and normal human prostate stromal immortalized WPMY-1 cells were treated with isoflurane, BACH1 and miR-375 expression was measured. Subsequently, PC3 and 22RV1 cells underwent gain- and… Show more

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“…37) Isoflurane promotes the viability, migration, and invasion of prostate cancer cells by activating BACH1 to upregulate miR-375 targeting PTEN. 38) ASCL1 positively regulates several super-enhancers-associated miRNAs enriched with H3K27ac labeling, such as miR-7, miR-375, miR-200b-3p, and miR-429, leading to molecular heterogeneity in small cell lung cancer. 39) The amplification of AK4P1 may promote the development and progression of pancreatic ductal adenocarcinoma by binding miR-375 to target YAP1.…”
Section: Discussionmentioning
confidence: 99%
“…37) Isoflurane promotes the viability, migration, and invasion of prostate cancer cells by activating BACH1 to upregulate miR-375 targeting PTEN. 38) ASCL1 positively regulates several super-enhancers-associated miRNAs enriched with H3K27ac labeling, such as miR-7, miR-375, miR-200b-3p, and miR-429, leading to molecular heterogeneity in small cell lung cancer. 39) The amplification of AK4P1 may promote the development and progression of pancreatic ductal adenocarcinoma by binding miR-375 to target YAP1.…”
Section: Discussionmentioning
confidence: 99%