Isoflurane

Capey, Steve

doi:10.1016/b978-008055232-3.61958-0

Cited by 3 publications

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding cardiac function, isoflurane has minimal impact on left ventricular function but does cause a dose-depen-dent decrease in systemic vascular resistance due to mild beta adrenergic stimulation. This action would lead to decreased cardiac preload and, in turn, decreased cardiac output, but a rise in heart rate mitigates the decrease in cardiac output 21 .…”

Section: Discussionmentioning

confidence: 99%

The Role of Anesthetic Techniques and Drugs in Laparotomy Cases of Postoperative Ileus

Puspita,

Nugroho,

Rahmasena

et al. 2024

magnamed

View full text Add to dashboard Cite

Background: Ileus occurs when there is a non-mechanical decrease or stoppage of the flow of intestinal contents. The cause of ileus has yet to be clearly defined. Various factors influence the risk for an ileus, each affecting a small part of the complex neuroimmune system. The patient will present with bloating and abdominal distension. Plain abdominal films and computed tomography (CT) scans of the abdomen are usually the first diagnostic imaging obtained. The most important principle for treating ileus is treating the underlying cause. Treating the infection, electrolyte abnormalities, and decreasing opiate use can all potentially decrease the durability of an ileus. Anesthesia procedures must be performed to treat patients preoperatively, during surgery, and postoperatively. Enhanced recovery protocols, regional anesthesia, opioid-sparing analgesics, and laparoscopy have all improved the number of postoperative ileus cases.Case Presentation: The following is a 67-year-old male patient who presents with abdominal pain with a scale of 4 out of 10, diagnosed with ileus, which was planned for laparotomy surgery by general anesthesia with supine position.Conclusion:We conclude that anesthetic procedures are critical in ileus patients in performing laparotomy operations, both in selecting anesthetic techniques, anesthetic drugs, and supporting scores (Aldrete score). Before induction, anesthesiologists must carefully assess preoperative and monitor postoperative

show abstract

Section: Discussionmentioning

confidence: 99%

The Role of Anesthetic Techniques and Drugs in Laparotomy Cases of Postoperative Ileus

Puspita,

Nugroho,

Rahmasena

et al. 2024

magnamed

View full text Add to dashboard Cite

show abstract

Differential rapid plasticity in auditory and visual responses in the primarily multisensory orbitofrontal cortex

Sharma

Bandyopadhyay

2019

Preprint

View full text Add to dashboard Cite

Word count is ≤250 19In a dynamic environment with rapidly changing contingencies, the orbitofrontal cortex (OFC) guides 20 flexible behavior through coding of stimulus value. Although stimulus-evoked responses in the OFC are 21 known to convey outcome, baseline sensory response properties in the mouse OFC are poorly 22 understood. To understand mechanisms involved in stimulus value/outcome encoding it is important to 23 know the response properties of single neurons in the mouse OFC, purely from a sensory perspective. 24Ruling out effects of behavioral state, memory and others, we studied the anesthetized mouse OFC 25 responses to auditory, visual and audiovisual/multisensory stimuli, multisensory associations and 26 sensory-driven input organization to the OFC. Almost all, OFC single neurons were found to be 27 multisensory in nature, with sublinear to supralinear integration of the component unisensory stimuli. 28With a novel multisensory oddball stimulus set, we show that the OFC receives both unisensory as well 29 as multisensory inputs, further corroborated by retrograde tracers showing labeling in secondary 30 auditory and visual cortices, which we find to also have similar multisensory integration and responses. 31With long audiovisual pairing/association, we show rapid plasticity in OFC single neurons, with a strong 32 visual bias, leading to a strong depression of auditory responses and effective enhancement of visual 33 responses. Such rapid multisensory association driven plasticity is absent in the auditory and visual 34 cortices, suggesting its emergence in the OFC. Based on the above results we propose a hypothetical 35 local circuit model in the OFC that integrates auditory and visual information which participates in 36 computing stimulus value in dynamic multisensory environments. 37 38 39 40 3 Significance Statement: Word count is ≤120 41Properties and modification of sensory responses of neurons in the orbitofrontal cortex (OFC) involved 42 in flexible behavior through stimulus value/outcome encoding are poorly understood. Such responses 43 are critical in providing the framework for the encoding of stimulus value based on behavioral context 44 while also directing plastic changes in sensory regions. The mouse OFC is found to be primarily 45 multisensory with varied nonlinear interactions, explained by unisensory and multisensory inputs. 46Audio-visual associations cause rapid plastic changes in the OFC, which bias visual responses while 47 suppressing auditory responses. Similar plasticity was absent in the sensory cortex. Thus the observed 48 intrinsic visual bias in the OFC weighs visual stimuli more than associated auditory stimuli in value 49 encoding in a dynamic multisensory environment. 50

show abstract

Differential Rapid Plasticity in Auditory and Visual Responses in the Primarily Multisensory Orbitofrontal Cortex

Sharma

Bandyopadhyay

2020

eNeuro

View full text Add to dashboard Cite

Given the connectivity of orbitofrontal cortex (OFC) with the sensory areas and areas involved in goal execution, it is likely that OFC, along with its function in reward processing, also has a role to play in perceptionbased multisensory decision-making. To understand mechanisms involved in multisensory decision-making, it is important to first know the encoding of different sensory stimuli in single neurons of the mouse OFC. Ruling out effects of behavioral state, memory, and others, we studied the anesthetized mouse OFC responses to auditory, visual, and audiovisual/multisensory stimuli, multisensory associations and sensory-driven input organization to the OFC. Almost all, OFC single neurons were found to be multisensory in nature, with sublinear to supralinear integration of the component unisensory stimuli. With a novel multisensory oddball stimulus set, we show that the OFC receives both unisensory as well as multisensory inputs, further corroborated by retrograde tracers showing labeling in secondary auditory and visual cortices, which we find to also have similar multisensory integration and responses. With long audiovisual pairing/association, we show rapid plasticity in OFC single neurons, with a strong visual bias, leading to a strong depression of auditory responses and effective enhancement of visual responses. Such rapid multisensory association driven plasticity is absent in the auditory and visual cortices, suggesting its emergence in the OFC. Based on the above results, we propose a hypothetical local circuit model in the OFC that integrates auditory and visual information which participates in computing stimulus value in dynamic multisensory environments.

show abstract

Isoflurane

Cited by 3 publications

References 5 publications

The Role of Anesthetic Techniques and Drugs in Laparotomy Cases of Postoperative Ileus

The Role of Anesthetic Techniques and Drugs in Laparotomy Cases of Postoperative Ileus

Differential rapid plasticity in auditory and visual responses in the primarily multisensory orbitofrontal cortex

Differential Rapid Plasticity in Auditory and Visual Responses in the Primarily Multisensory Orbitofrontal Cortex

Contact Info

Product

Resources

About