Abstract:Transporting epithelial cells of the gut and kidney interact with their luminal environment through a densely-packed collection of apical microvilli known as the brush border. Proper brush border assembly depends on the intermicrovillar adhesion complex (IMAC), a protocadherin-based adhesion complex found at the distal tips of microvilli that mediates adhesion between neighboring protrusions to promote their organized packing. Loss of the IMAC adhesion molecule Cadherin-related family member 5 (CDHR5) correlat… Show more
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