Isogenic venous graft supported with bone marrow stromal cells as a natural conduit for bridging a 20 mm nerve gap

Nijhuis, T.; Brzezicki, Grzegorz; Klimczak, Aleksandra; Siemionow, Maria

doi:10.1002/micr.20818

Cited by 28 publications

(33 citation statements)

References 33 publications

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“…A few examples of these additives uses are nerve growth factor, Schwann cells, and several types of The effect of stem cells in bridging peripheral nerve defects: a meta-analysis stem cells. 4,15,34,36,47,56 A number of different types of stem cells have been used in animal experiments focusing on nerve regeneration in a nerve reconstruction model. Bone marrow stromal cells (BMSCs), adipose-derived stromal cells (ADSCs), hair follicle stem cells, skin-derived mesenchymal stem cells, and amniotic fluid-derived mesenchymal stem cells can all be applied.…”

Section: ©Aans 2014mentioning

confidence: 99%

“…48 Another theory, however, regarding the beneficial effect of BMSCs is that they function as growth promoting factors. 34 ADSCs are less invasive to harvest as they can be derived from belly fat or other adipocyte-containing tissue. They have a comparable phenotypic profile as the BMSCs, and some studies have even indicated that ADSCs have a more profound tendency to transdifferentiate into a Schwann cell-like phenotype.…”

Section: ©Aans 2014mentioning

confidence: 99%

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The effect of stem cells in bridging peripheral nerve defects: a meta-analysis

Hundepool

Nijhuis

Mohseny

et al. 2014

JNS

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Object. For decades the gold standard for reconstructing a large peripheral nerve defect has been, and remains, the nerve autograft. Alternatives to the nerve autograft include biological conduits and vessels. Adding stem cells in the lumen of a nerve conduit has been the subject of multiple studies. The purpose of the present meta-analysis was to summarize animal experimental studies on the effect of stem cells as a luminal additive when reconstructing a peripheral nerve defect with a nerve graft.Methods. A literature search of the MEDLINE and Embase databases was performed from inception to April 2012, searching for animal experiments on peripheral nerve reconstruction models in which a nerve conduit was used with and without the support of 3 different types of stem cells. Stem cells were analyzed according to their origin: bone marrow, adipose tissue, and other origins. Included studies had consistent outcome measurements: walking track analysis, muscle mass ratio, and electrophysiology.Results. Forty-four studies were included in the final analysis. Forest plots of the 3 outcome measurements (walking track analysis, muscle mass ratio, and electrophysiology) showed positive effects of stem cells on the regeneration of peripheral nerves at different time points. Almost all comparisons showed significant differences for all 3 stem cells groups compared with a control group in which stem cells were not used.Conclusions. The present report systematically analyzed the different studies that used stem cells as a luminal additive when bridging a large peripheral nerve defect. All 3 different stem cell groups showed a beneficial effect when used in the reconstruction compared with control groups in which stem cells were not used. (http://thejns.org/doi/abs/10.3171/2014.4.JNS131260) Key WordS • peripheral nerve defect • stem cells • regeneration • meta-analysisAbbreviations used in this paper: ADSC = adipose-derived stromal cell; BMSC = bone marrow stromal cell; MM = muscle mass ratio; NCV = nerve conduction velocity SFI = Sciatic Functional Index.

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Section: ©Aans 2014mentioning

confidence: 99%

Section: ©Aans 2014mentioning

confidence: 99%

The effect of stem cells in bridging peripheral nerve defects: a meta-analysis

Hundepool

Nijhuis

Mohseny

et al. 2014

JNS

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“…Interestingly, however, the positive effects of undifferentiated cells have also been widely reported [5,7,13,[32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] . These investigators claim that in vitro differentiation incurs an unnecessary delay, limiting clinical applicability.…”

Section: Differentiationmentioning

confidence: 99%

“…Under appropriate conditions BMSCs can differentiate into non-mesodermal lineages such as neurons, astrocytes and SC-like cells [90] . Many studies have shown that the addition of BMSCs to conduits and acellular grafts results in superior outcomes when compared with empty or cell deplete channels [24,[36][37][38]40,41] . Although some have failed to show that BMSCs can match outcomes achieved with cultured SCs [20] , the majority of reports show that performance is at least equivalent [27,43,91] .…”

Section: Bone Marrow Derived Stem Cellsmentioning

confidence: 99%

Augmenting peripheral nerve regeneration using stem cells: A review of current opinion

Fairbairn

Meppelink

Ng-Glazier

et al. 2015

WJSC

129

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Outcomes following peripheral nerve injury remain frustratingly poor. The reasons for this are multifactorial, although maintaining a growth permissive environment in the distal nerve stump following repair is arguably the most important. The optimal environment for axonal regeneration relies on the synthesis and release of many biochemical mediators that are temporally and spatially regulated with a high level of incompletely understood complexity. The Schwann cell (SC) has emerged as a key player in this process. Prolonged periods of distal nerve stump denervation, characteristic of large gaps and proximal injuries, have been associated with a reduction in SC number and ability to support regenerating axons. Cell based therapy offers a potential therapy for the improvement of outcomes following peripheral nerve reconstruction. Stem cells have the potential to increase the number of SCs and prolong their ability to support regeneration. They may also have the ability to rescue and replenish populations of chromatolytic and apoptotic neurons following axotomy. Finally, they can be used in non-physiologic ways to preserve injured tissues such as denervated muscle while neuronal ingrowth has not yet occurred. Aside from stem cell type, careful consideration must be given to differentiation status, how stem cells are supported following transplantation and how they will be delivered to the site of injury. It is the aim of this article to review current opinions on the strategies of stem cell based therapy for the augmentation of peripheral nerve regeneration.

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“…The vein as a natural replacement was already promoted in 1982 by Chiu et al [ 9 ]. In 2010 we showed that vein grafts are more abundantly available in a wide variety of sizes and lengths, have minimal donor morbidity, and provide a metabolically supportive environment for the regenerating axons [ 5 ]. Zhang et al demonstrated that the wall of the vein has an additional advantage providing a barrier against scar ingrowth [ 10 ].…”

Section: Vein Graftmentioning

confidence: 98%

Venous Conduit as a Model for Nerve Regeneration

Nijhuis

2014

Plastic and Reconstructive Surgery

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Up to this day, despite general improvements in safety precautions in both private and work environments, peripheral nerve trauma still occurs. One can image that the prevalence of these trauma related nerve injuries will decrease slowly in the Western civilization, but remains stable in countries developing their economy in a fast pace and industries primary goals thus not focus on safety regulations issues. Nevertheless the prevalence ranging between 2.8 and 5 % of peripheral nerve trauma in all open wounds remains rather stable (IJkema-Paassen et al. Biomaterials 25:1583-92, 2004 Noble et al. J Trauma 45:116-22, 1998). That being said it is clear that nerve reconstruction is of vital importance in the trauma and reconstructive care.

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Isogenic venous graft supported with bone marrow stromal cells as a natural conduit for bridging a 20 mm nerve gap

Cited by 28 publications

References 33 publications

The effect of stem cells in bridging peripheral nerve defects: a meta-analysis

The effect of stem cells in bridging peripheral nerve defects: a meta-analysis

Augmenting peripheral nerve regeneration using stem cells: A review of current opinion

Venous Conduit as a Model for Nerve Regeneration

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