For the direct differentiation technique-based modeling of acoustic fluid–structure interaction and structural-acoustic sensitivity analysis, a coupling algorithm based on the finite element method (FEM) and the fast multipole boundary element method (FMBEM) is suggested. By bypassing the challenging volume parameterization process in isogeometric finite element techniques and the laborious meshing process in traditional FEM/BEM, non-uniform rational B-splines (NURBS) isogeometric analysis (IGA) is utilized to immediately perform numerical analysis on CAD models. The matrix-vector products in the boundary element analysis are accelerated using the fast multipole method (FMM). To hasten the solution of the linear system of equations, the iterative solver GMRES is used. The numerical prediction of the effects of arbitrarily shaped vibrating structures on the sound field is made feasible by the FEM/FMBEM technique. A number of numerical examples are provided to show the applicability and effectiveness of the suggested approach.