Isokinetic predictors of gait speed increase following high-intensity resistance training of the ankle dorsiflexors in people with multiple sclerosis: A pilot study

Comparative Effectiveness of 4 Exercise Interventions Followed by 2 Years of Exercise Maintenance in Multiple Sclerosis: A Randomized Controlled Trial

“…9 An important result was that 25 sessions of exercise of any type did not exacerbate MS symptoms. [54][55][56][57] Recent reviews of exercise studies in patients with neurodegenerative diseases, including MS, identified no studies that were longer than 12 months, and none included a maintenance program after an initial exercise period. 6,7,9 Long-term exercise intervention studies are needed because the favorable effects tend to disappear after the exercise stimulus is withdrawn, implying the need to incorporate exercise and physical activity daily into the lives of PwMS.…”

“…7,[10][11][12][13]58 Instead, we wished to extend the current shift in paradigm to using a high-intensity and high-frequency exercise conditioning period of 5 weeks (25 sessions). 8,9,[53][54][55][56][57]59,60 We sought to determine if the initial exercise effects can be boosted or at least sustained by a thrice weekly maintenance , supplement 1, available online only at http://www.archivespmr.org/). We found that any of 4 forms of exercise maintenance slowed symptom worsening and improved QOL with EXE producing the greatest effects.…”

Effects of Maximal Strength Training on Perceived-Fatigue and Functional Mobility in Persons with Relapsing-Remitting Multiple Sclerosis

“…Nevertheless, resistance training appears to have some advantages above other exercise regimens [ 9 ] as it produces improvements in neural drive [ 10 ] as well as in the efferent motor output of spinal motor neurons in pwMS [ 11 ]. This leads to enhancements not only in strength but also in balance [ 11 ] and functional mobility [ 12 , 13 ], which are particularly important for the QoL of this population [ 11 ]. Additionally, resistance training seems to be better tolerated by this population (especially by the most sedentary individuals), as their body temperature does not increase overmuch.…”