Isolamento de Haemophiliis aegyptius associado à Febre Purpúrica Brasileira, de cloropídeos (Diptera) dos gêneros Hippelates e Liohippelates

Abstract

O reconhecimento da Febre Purpúrica Brasileira (FPB), em 1984, originou uma série de estudos que revelaram uma correlação desta doença com conjuntivites causadas por Haemophiliis aegyptius. A associação do aumento de conjuntivites em crianças e a maior densidade populacional de cloropídeos do gênero Hippelates já havia sido verificada desde o século passado. Este fenômeno está relacionado ao tropismo que estes insetos apresentam pelos olhos, secreções e feridas de onde se alimentam. Embora haja evidências do papel destes cloropídeos na transmissão mecânica de conjuntivites bacterianas, o isolamento de Haemophilus aegyptius a partir dos mesmos, no seu habitat natural, ainda não havia sido verificado. No presente trabalho obtivemos o isolamento de cepas invasivas de Haemophilus aegyptius, associadas à FPB, de duas coleções de cloropídeos, classificados como Liohippelates peruanus e uma espécie nova, Hippelates neoproboscideus, coletados ao redor dos olhos de crianças com conjuntivite.

Preliminary evidence that synanthropic flies contribute to the transmission of trachoma- causing Chlamydia trachomatis in Latin America

“…No previous studies had been conducted to assess potential vectors in Latin America. However, eye gnats are serious pests to humans and animals in the southern half of North America (particularly Hippelates collusor in southern California), where they are thought to mechanically transmit conjunctivitis, yaws, and bovine mastitis 8,14 , and have been implicated as vectors initiating epidemic bacterial conjunctivitis 14 . In southern Brazil, Haemophilus aegyptius, the causative agent of acute conjunctivitis, has been isolated from eye gnats collected from around the eyes of children 8 .…”

“…and Liohippelates spp.) are likely to constitute an important vector group since like M. sorbens they swarm around eyes and bodily secretions 7 and can transmit Brazilian purpuric fever, for which the initial symptom is an acute conjunctivitis 8 .…”

Suspected Brazilian Purpuric Fever, Brazilian Amazon Region

“…To the Editor: Brazilian purpuric fever (BPF), a Haemophilus aegyptius-caused febrile hemorrhagic illness of children that begins with conjunctivitis and has a case-fatality rate of 40%-90% (1,2), was fi rst recognized during a 1984 outbreak. Before June 2007, 69 cases were reported worldwide; 65 were from Brazil (1-3).…”

Emergence and Disappearance of a Virulent Clone of Haemophilus influenzae Biogroup aegyptius, Cause of Brazilian Purpuric Fever

“…Tondella et al isolated BPF clone strains of H. aegyptius associated with BPF from two pools of Hippelates and Liohippelates flies that were collected from around the eyes of children with conjunctivitis (58). These results suggested the participation of these species in the mechanical transmission of the BPF clone of H. aegyptius.…”