Isolated abdominal wall metastasis from renal cell carcinoma: Unusual presentation

Shmayyes

Annals of Medicine &Amp; Surgery

et al. 2023

Introduction and Importance: In 2020, renal cell carcinoma (RCC) had an incidence of 73 750 new cases. This cancer is well known for its ability to give early and late metastases to some usual and unusual sites. The term ‘late recurrence’ is widely used to indicate a period exceeding 10 years from curative nephrectomy. This not-understood behaviour is almost specific to RCC, and it happens in a range between 4.3 and 11% of cases of RCC. Case Presentation: We report a case of a 67-year-old nonalcoholic smoker Syrian male presented with a 2-month painful mass located at the left upper posterolateral abdominal wall’s region. He has had a history of left chromophobe cell RCC treated with radical nephrectomy with adjuvant radiotherapy for 12 years. In light of computed tomography’s findings, a surgical biopsy was performed, and a pathological and immunohistochemical examination confirmed the diagnosis of chromophobe RCC. Clinical Discussion: Malignant cells seeding the surgical cut path and staying dormant for 12 years is the best theory of many to explain our case. Conclusion: We reported evidence for the potential of a relatively indolent histologic type of RCC (i.e. chromophobe cell carcinoma) to cause late recurrence after 12 years to a very rare site (i.e. abdominal wall’s superficial muscles). Research should focus on addressing late recurrence to determine the best surveillance protocols; investigating malignant cells seeding during surgery to improve surgical oncology’s outcomes; and studying late recurrence’s genetics to boost our targeted therapy options.

Section: Discussionmentioning

confidence: 87%

“…RCC’s metastases are common, and around 16% of cases have metastatic disease on presentation 8 . Metastases can spread directly into the nearby organs and can spread into any organ by lymph system or bloodstream 9 , and it is well known for its capacity to occur even many years after curative nephrectomy.…”

Section: Discussionmentioning

confidence: 99%

Late recurrence of chromophobe renal cell carcinoma to unusual sites after 12 years of radical nephrectomy and radiotherapy: a rare case report from Syria

Shmayyes

Annals of Medicine &Amp; Surgery

et al. 2023

“…RCCs are a heterogeneous group of tumors with 1/3rd of patients already having distant metastases at the time of diagnosis and in 1/4th of patient’s metastasis occurs after radical nephrectomy. The tumors frequently metastasize to the lung (50–75%), bone (30–40%), liver (30–40%), brain and thyroid (25%) [ 1 ]. This event usually occurs after many years but could be the presenting feature of underlying cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Renal cell carcinoma (RCC) is one of the most aggressive genitourinary cancers with unpredictable and diverse behavior [ 1 ]. There has been an increase in the incidence of RCCs over the last 2 decades [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Scar site metastasis of renal cell carcinoma diagnosed on-site cytology: a case report

et al. 2018

BackgroundRenal cell carcinomas (RCCs) have a propensity for widespread metastases and a wide range of survival rates. They can spread into adjacent organs by direct extension and can invade local or distant sites by lymphatic, hematogenous or lympho-hematogeneous pathways. Scar site metastasis is very rare.Case presentationWe report a rare case of scar site RCC metastasis in a patient who underwent left radical nephrectomy 10 months ago.ConclusionFNAC is a simple and easy technique that can help in the definitive diagnosis of subcutaneous lesions. A correct early stage diagnosis of metastatic RCC can considerably improve the survival rates.

Carcinoma of the Ovary Presenting as Cutaneous Metastases

Venugopal¹,

Duthaluri²,

Purushothamanan³

et al. 2016

CRCM

Introduction: Cutaneous metastasis is common from malignancies of the genitourinary system and occasionally from the digestive system. Cutaneous metastases, due to ovarian carcinoma as a presenting feature, being diagnosed on cytology, are uncommonly reported. Case Report: A 70-year-old lady presented with a cutaneous nodule and progressive abdominal distension. Investigations for metastatic nodule showed it to be a lesion from the ovary. Discussion: Carcinoma ovary is often diagnosed when patients present with ascites and the association with a parietal wall deposit is uncommon. The occurrence of a parietal wall nodule when the ascites is negative for malignant cells is not previously documented. Conclusion: We discuss literature of the malignancies that present with a parietal wall metastases and the management of ovarian carcinoma.