Isolated Acute Thrombocytopenia in a 21-Year-Old Caucasian Male

Beavers, Charles; Kern, William; Blick, Kenneth E.

doi:10.1309/lmgib39r5hhcraso

Cited by 1 publication

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“…8 A bone marrow biopsy may reveal megakaryocytes suggestive of increased production of platelets or bone marrow suppression, which indicates a disseminated form of tuberculosis causing low platelets. This association has been infrequently reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Surgery is an Option

Khurshid¹,

Albanese²,

Carey³

2014

Infectious Diseases in Clinical Practice

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Background: Mycobacterium tuberculosis may affect any organ.Thrombocytopenia is a rare manifestation of tuberculosis. We report a case of tuberculosis with refractory immune thrombocytopenic purpura requiring splenectomy.Case Report: A 26-year-old man from China presented with epistaxis, generalized purpuric lesions, difficulty in breathing, productive cough, night sweats for 2 months, and a 15-lb weight loss during the previous 6 months. A petechial rash was noted over the chest, anterior abdominal wall, and extremities. Laboratory results revealed anemia and severe thrombocytopenia. Chest x-ray showed bilateral upper lobe cavitations. Sputum sample confirmed the diagnosis of Mycobacterium tuberculosis. A bone marrow biopsy showed mild hypercellularity of all cell lines with megakaryocytes increased in numbers. Therapy with steroids and immunoglobulin was unsuccessful to treat platelet crisis. After splenectomy, platelet count returned to baseline.Conclusions: Our case represents a rare clinical phenomenon. In refractory immune thrombocytopenic purpura cases, splenectomy may be essential for the patient survival.

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Section: Discussionmentioning

confidence: 99%