Isolated and synergistic effects of chemical and structural defenses of two species of Tethya (Porifera: Demospongiae)

Ribeiro, Suzi Meneses; Cassiano, Keila Mara; Cavalcanti, Diana Negrão; Teixeira, Valéria Laneuville; Pereira, Renato Crespo

doi:10.1016/j.seares.2011.12.002

Cited by 7 publications

(10 citation statements)

References 57 publications

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“…Cancer is a global catastrophe, and one of the leading causes of mortality. Although numerous chemotherapeutic agents have been of which six are identical to the sterols found in DGEHF2-1 (Ribeiro, Cassiano, Cavalcanti, Teixeira, & Pereira, 2012). We were able to find several previous studies that discussed the anticancer potential of the compounds reported in the percentage study.…”

Section: Discussionmentioning

confidence: 67%

“…Sarma et al provided a comprehensive report about the sterols that are present in soft corals. Interestingly, Ribeiro et al reported the identification of eight sterol derivatives from sponges Tethya rubra and Tethya maza , of which six are identical to the sterols found in DGEHF2‐1 (Ribeiro, Cassiano, Cavalcanti, Teixeira, & Pereira, ). We were able to find several previous studies that discussed the anticancer potential of the compounds reported in the percentage study.…”

Section: Discussionmentioning

confidence: 99%

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Apoptotic and antiproliferative properties of 3β‐hydroxy‐Δ5‐steroidal congeners from a partially purified column fraction of Dendronephthya gigantea against HL‐60 and MCF‐7 cancer cells

Fernando

Sanjeewa

Kim

et al. 2017

J of Applied Toxicology

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Organisms belonging to the genus Dendronephthya are among a group of marine invertebrates that produce a variety of terpenoids with biofunctional properties. Many of these terpenoids have been proven effective as anticancer drugs. Here, we report the antiproliferative effect of 3β-hydroxy-Δ5-steroidal congeners against the proliferation of HL-60 human leukemia cells and MCF-7 human breast cancer cells. The sterol-rich fraction (DGEHF2-1) inhibited the growth of HL-60 and MCF-7 cells with IC values of 13.59 ± 1.40 and 29.41 ± 0.87 μg ml respectively. Treatment with DGEHF2-1 caused a dose-dependent increase in apoptotic body formation, DNA damage and the sub-G apoptotic cell population. Moreover, DGEHF2-1 downregulated the expression of Bcl-xL while upregulating Bax, caspase-9, and PARP cleavage in both HL-60 and MCF-7 cells. The steroid fraction was found to act via the mitochondria-mediated apoptosis pathway. Identification of the sterols was performed via gas chromatography-tandem mass spectrometry analysis. Studying the mechanism of the anticancer effect caused by these sterol derivatives could lead to the identification of other natural products with anticancer properties.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Apoptotic and antiproliferative properties of 3β‐hydroxy‐Δ5‐steroidal congeners from a partially purified column fraction of Dendronephthya gigantea against HL‐60 and MCF‐7 cancer cells

Fernando

Sanjeewa

Kim

et al. 2017

J of Applied Toxicology

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“…The few studies in which the possible synergism between structural defenses and crude extracts from sponges has been considered showed disparate results (e.g. Hay et al 1994, Burns & Ilan 2003, Hill et al 2005, Jones et al 2005, Ribeiro et al 2012.…”

Section: Discussionmentioning

confidence: 99%

Calcareous spherules produced by intracellular symbiotic bacteria protect the sponge Hemimycale columella from predation better than secondary metabolites

Garate¹,

Blanquer

Uriz³

2015

Mar. Ecol. Prog. Ser.

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Benthic sessile organisms in general, and sponges in particular, have developed an array of defense mechanisms to survive in crowded, resource and/or space-limited environments. Indeed, various defense mechanisms may converge in sponges to accomplish a defensive function in an additive or synergetic way, or to operate at different times during the sponge's life cycle. Moreover, sponges harbor highly diverse microbial communities that contribute in several ways to the host's success. Although some symbiotic bacteria produce chemical compounds that protect the sponge from predation, the possible deterrent function exerted by the calcareous coat of a sponge's endosymbiotic bacterium has not, to date, been explored. Hemimycale columella is an Atlanto-Mediterranean sponge, which produces bioactive metabolites and has been reported to host an intracellular bacterium with a calcite envelope. Calcibacteria accumulate in high densities at the sponge periphery, forming a kind of sub-ectosomal cortex. They have been suggested to provide the sponge with several benefits, one of which is protection from predators. In this study, we assess the relative contribution of the endosymbiotic calcibacteria and bioactive compounds produced by H. columella to defend the sponge against sympatric predators. Deterrence experiments have revealed that the sponge combines >1 defense mechanism to dissuade a large array of potential predators; this represents an example of the evolutionary fixation of redundant mechanisms of defense. The chemicals deterred Paracentrotus lividus, Chromis chromis, Oblada melanura, and Diplodus vulgaris, but not Parablennius incognitus and Coris julis, while the spherules of the symbiotic calcibacteria significantly deterred all predators assayed.

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“…Purification of the extract gave mixtures of sterols and fatty acids as active components. In the sterol mixture, there are several sterols, (24S)-24-methylcholesta-5(E),22-dien-3β-ol (= pincsterol) or (24R)-24-methylcholesta-5(E),22-dien-3β-ol (= brassicasterol) (106) [98], cholesterol (26) [30] (Figure 5), β-sitosterol (stigmasta-5-en-3β-ol) (39) [48], and β-cholestanol (5α-cholestan-3β-ol) (107) [99] were identified and sterol 39 in this study [97] was found to contain 35% of a 24S epimer (clionasterol) (108) [100,101] (Figure 17). Sterol 39 had the highest antifouling activity among sterols 26, 39, and 107 [97].…”

Section: Dendronephthya Sppmentioning

confidence: 99%

Natural Products from Octocorals of the Genus Dendronephthya (Family Nephtheidae)

Chen¹,

Chang

Chen

et al. 2020

Molecules

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In this review, 170 natural substances, including steroid, diterpenoid, sesquiterpenoid, peptide, prostaglandin, base, chlorolipid, bicyclolactone, amide, piperazine, polyketide, glycerol, benzoic acid, glycyrrhetyl amino acid, hexitol, pentanoic acid, aminoethyl ester, octadecanone, alkaloid, and a 53-kD allergenic component from octocorals belonging to genus Dendronephthya, were listed. Some of these compounds displayed potential bioactivities.

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Isolated and synergistic effects of chemical and structural defenses of two species of Tethya (Porifera: Demospongiae)

Cited by 7 publications

References 57 publications

Apoptotic and antiproliferative properties of 3β‐hydroxy‐Δ5‐steroidal congeners from a partially purified column fraction of Dendronephthya gigantea against HL‐60 and MCF‐7 cancer cells

Apoptotic and antiproliferative properties of 3β‐hydroxy‐Δ5‐steroidal congeners from a partially purified column fraction of Dendronephthya gigantea against HL‐60 and MCF‐7 cancer cells

Calcareous spherules produced by intracellular symbiotic bacteria protect the sponge Hemimycale columella from predation better than secondary metabolites

Natural Products from Octocorals of the Genus Dendronephthya (Family Nephtheidae)

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