Isolated cilioretinal artery occlusion as an initial manifestation of polycythemia vera

Elasri, Fouad; Souhail, H.; Karim, Rezaul; Idrissi, Assia; Naoumi, A.; Oubaaz, Abdelbarre

doi:10.4103/0974-9233.65493

Cited by 12 publications

(8 citation statements)

References 5 publications

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“…Both central retinal artery occlusions (CRAO) [35,57,[68][69][70][71] and central retinal venous occlusions (CRVO) [34,37,41,72,73] have been reported numerous times in all the three types of MPNs. Other types of retinal occlusions or lateral posterior ciliary artery occlusions have been described [6,14,37,38,[72][73][74][75][76][77]. Interestingly a retrospective audit was conducted on JAK2V617F requests to address the clinical value of requesting this mutation status in patients with retinal vein or artery occlusion.…”

Section: Vaso-occlusions Haemorrhages and Microangiopathymentioning

confidence: 99%

Ocular Manifestations in Patients with Philadelphia-Negative Myeloproliferative Neoplasms

Liisborg

Hasselbalch

Sørensen

2020

Cancers

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The major complications of Philadelphia-negative (Ph-Negative) myeloproliferative neoplasms (MPNs) are thrombosis, haemorrhage and leukemic transformation. As systemic and haematological diseases, MPNs have the potential to affect many tissues and organs. Some complications lead to the diagnosis of MPNs, but other signs and symptoms are often misdiagnosed or neglected as a sign of MPN disease. Therefore, we reviewed the current literature to investigate and delineate the clinical manifestations seen in the eyes of Ph-negative MPN patients. We found that ocular manifestations are common among patients with MPNs. The most frequently described manifestations are due to the consequences of haematological abnormalities causing microvascular disturbances and hyperviscosity. More serious and vision-threatening complications as thrombotic events in the eyes have been repeatedly reported as well. These ocular symptoms may precede more serious extraocular complications. Accordingly, combined ophthalmological and haematological management have the potential to discover these diseases earlier and prevent morbidity and mortality in these patients. Furthermore, routine ophthalmological screening of all newly diagnosed MPN patients may be a preventive approach for early diagnosis and timely treatment of the ocular manifestations.

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Section: Vaso-occlusions Haemorrhages and Microangiopathymentioning

confidence: 99%

Ocular Manifestations in Patients with Philadelphia-Negative Myeloproliferative Neoplasms

Liisborg

Hasselbalch

Sørensen

2020

Cancers

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“…Ophthalmic involvement in PV has been reported to include central retinal vein occlusion, isolated cilioretinal artery occlusion, ischemic retinopathy with cotton-wool spots, peripheral retinal neovascularization, bilateral anterior ischemic optic neuropathy, and isolated trochlear nerve palsy. [4][5][6][7][8][9][10] Case Report A 49-year-old White Hispanic man presented to our clinic with 2 acute episodes of transient monocular vision loss in his right eye, described as a dense blurriness that lasted for 3 to 5 minutes. He had no other complaints, and his comprehensive ophthalmologic and neurologic examinations were normal.…”

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confidence: 99%

Jak2 Mutation-Positive Polycythemia Vera Presenting as Central Retinal Artery Occlusion

Dhrami-Gavazi

Lee

Horowitz

et al. 2015

RETINAL Cases &Amp; Brief Reports

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“…Group 2 patients were characterized clinically by plaque-like focal retinal whitening simulating some cases of cilioretinal arterial occlusion. 21 The lesions progressed to develop intralesional hemorrhages and started spreading in a centrifugal manner. OCT characteristically showed significant retinal thinning and necrosis.…”

Section: Discussionmentioning

confidence: 99%

An imaging-based treatment algorithm for posterior focal retinitis

et al. 2018

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Background:In this paper, our aim was to describe an imaging-based empirical approach for categorizing and initiating treatment of immunocompetent patients with posterior focal retinitis, prior to the availability of results of expensive laboratory investigations.Materials and methods:The hospital records of 13 patients with posterior focal retinitis were reviewed.Results:Of the 13 patients, 9 were women and 4 were men. The mean age was 24 ± 8 years. Based on similarities in clinical presentation and imaging, we categorized our cases into three groups with different first-line therapeutic strategies. In the first group, patients had presumed toxoplasmosis (treated with oral cotrimoxazole); in the second group, patients had presumed viral (herpetic) etiology (treated with oral valacyclovir); and in the third group, patients had presumed nonherpetic, nontoxoplasma retinitis (treated with oral doxycycline). Positive serology results included Rickettsia (two patients), Borrelia (one patient), Toxoplasma (two patients), and herpes simplex virus (one patient).Conclusion:An empirical approach for early initiation of therapy in retinitis cases based on imaging features is described.

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Isolated cilioretinal artery occlusion as an initial manifestation of polycythemia vera

Abstract: Isolated cilioretinal artery occlusion is a rarely reported initial manifestation of polycythemia vera. In this study, we reported a case of a 65-year-old man with polycythemia vera with cilioretinal artery occlusion as an initial manifestation.

Cited by 12 publications

References 5 publications

Ocular Manifestations in Patients with Philadelphia-Negative Myeloproliferative Neoplasms

Ocular Manifestations in Patients with Philadelphia-Negative Myeloproliferative Neoplasms

Jak2 Mutation-Positive Polycythemia Vera Presenting as Central Retinal Artery Occlusion

An imaging-based treatment algorithm for posterior focal retinitis

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