Multiple sclerosis (MS) is very similar to the Gougerot Sjögren Syndrome (GSS) by its clinical presentations. Features found in common between the two disorders include symptoms of lesions of the brain, spinal cord and optic tract, the detection of autoantibodies, such as antinuclear, anti-Ro, anti-La and the prevalence of MRI abnormalities such as periventricular and subcortical lesions. Almost all symptoms found in patients with the central nervous system (CNS) -GSS involvement described above could be attributed to the concomitant presence of MS. Therefore, the differential diagnosis of these diseases is difficult. The authors present the case of a 26 years old woman who presented a GSS with neurological manifestations mimicking MS.