Isolated demyelinating syndromes: comparison of CSF oligoclonal bands and                 different MR imaging criteria to predict conversion to CDMS

Tintoré, Mar; Rovira, A.; Brieva, Luís; Grivé, Elisenda; Jardí, R.; Borrás, Cecilia; Montalbán, Xavier

doi:10.1177/135245850100700603

Cited by 193 publications

(173 citation statements)

References 22 publications

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“…[14] Eight studies [4,6,11,17,19,20,25,26] had performed subgroup analyses based on the number of different lesions. Eleven studies [2,7,8,12,13,17,18,[21][22][23]26] did not report the number of exclusions or lost to follow-up during the study period. Two studies [6,26] described the incidence of MS in CIS patients for the first time MRI in different parts of demyelinating lesions.…”

Section: Study Characteristicsmentioning

confidence: 92%

“…[21] Six studies, [4,6,8,[19][20][21] which described CIS patients were treated with drugs during the study period. MS was diagnosed in 15 studies [3][4][5][6][9][10][11][12][15][16][17][18][19]22,26] by Poser criteria; CIS patients developed MS according to McDonald criteria in eight studies, [7,8,13,20,21,[23][24][25] and one study according to Schumacher criteria. [14] Eight studies [4,6,11,17,19,20,25,26] had performed subgroup analyses based on the number of different lesions.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Prognostic value of magnetic resonance imaging in patients with clinically isolated syndrome conversion to multiple sclerosis: A meta-analysis

Zhang

Hou

2013

Neurol India

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Despite some limitations, this meta-analysis established solid statistical evidence for an association between the presence or absence of MRI lesions within the brain or spinal cord MRI and the risk of developing MS, particularly for studies with large sample size. The CIS patients with abnormal baseline MRI, especially with infratentorial lesions, had a high risk of conversion to MS. However, this association warrants additional validation in larger and well designed studies.

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Section: Study Characteristicsmentioning

confidence: 92%

Section: Study Characteristicsmentioning

confidence: 99%

Prognostic value of magnetic resonance imaging in patients with clinically isolated syndrome conversion to multiple sclerosis: A meta-analysis

Zhang

Hou

2013

Neurol India

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“…If needed, further investigation (such as immunological screening, MRI, evoked potential) was conducted at our hospital. The 15) were used to classify any MRI abnormalities. The results were assessed by using the McDonald's criteria (16), and the diagnosis was established.…”

Section: Methodsmentioning

confidence: 99%

Multipl Skleroz Prevelansı: Türkiye’nin Kuzey Doğusunda Epidemiyolojik Saha Çalışması

...

2012

npa

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Ge liş ta ri hi/Re cei ved: 27.04.2011 Ka bul ta ri hi/Ac cep ted: 19.10.2011 © Nö rop si ki yat ri Ar şi vi Der gi si, Ga le nos Ya yı ne vi ta ra f›n dan ba s›l m›fl t›r. / © Arc hi ves of Neu ropsy chi atry, pub lis hed by Ga le nos Pub lis hing ABS TRACTBackground: The prevalence rate of multiple sclerosis (MS) might differ between countries depending on whether the data is obtained from hospital-based or population-based studies. This study aimed at identifying the prevalence of MS with face-to-face interviews by door-to-door field visits in a population study conducted in the north-eastern (Caucasus) part of Turkey situated at high altitude, with long winters and with inhabitants having low socio-economical status. Method: In this cross-sectional field study, one of every three houses within the city proper were visited searching for MS cases. Results: 7249 subjects were included in face-to-face interviews. Five patients diagnosed as having MS were identified. The prevalence of MS was calculated as 68.97/100000, with a mean age of 35.1±10.2 years and female to male ratio of 4/1. Conclusion: This study, similar to the previous population-based study conducted in our country, demonstrated that the prevalence of MS in Turkey could be higher than expected. (Arc hi ves of Neu ropsy chi atry 2012; 49: 272-275) Key words: Multiple sclerosis, prevalence, epidemiologic field stud Conflict of interest: The authors reported no conflict of interest related to this article. ÖZET Amaç: Multipl skleroz (MS) prevelans oranı, yapılan çalışmaların toplum veya hastane kaynaklı olmasına bağlı olarak, ulkeler arasında farklılık göstermektedir. Bu çalışmamızda amacımız sosyoekonomik seviyesi duşuk, coğrafi açıdan yuksek rakımda, mevsimsel olarak uzun suren kış aylarının olduğu ulkemizin kuzey-doğu illerinden Kars'ta, yuz yuze ve kapı kapı gezilerek, MS prevelansını tespit etmektir. Yöntem: Bu kesitsel alan çalışmasında, MS olgusu ararken tum kentte belirlenen her uç evden birine ziyaret yapıldı. Bulgular: Toplam 7249 kişi ile yuz yuze göruşmeler yapıldı. MS tanısı konmuş 5 hasta tespit edildi. MS prevelansı 68,97/100000, kadın erkek oranı 4/1, hastaların yaş ortalaması 35,1±10,2 olarak hesaplandı. Sonuç: Bu çalışma, ulkemizde daha önce yapılan benzer çalışma ile benzer şekilde, MS prevelansının tahmin edilen değerden daha yuksek olabileceğini bize göstermektedir. (Nö rop si ki yat ri Ar fli vi 2012; 49: 272-275) Anah tar ke li me ler: Multipl skleroz, prevelans, epidemiyolojik saha çalışması Çıkar çatışması: Yazarlar bu makale ile ilgili olarak herhangi bir çıkar çatışması bildirmemişlerdir.

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“…A second group of 70 clinically isolated syndrome patients allowed the gadolinium enhancing lesion to be replaced by nine T2 lesions and demonstrated that having three or four criteria gave the greatest accuracy (table 1). 3…”

Section: Ms and The Clinically Isolated Syndromementioning

confidence: 99%

When confronted by a patient with the radiologically isolated syndrome

Chataway

2010

Pract Neurol

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As MRI becomes ever easier to access, it is clear that there is a group of patients, scanned for a wide range of symptoms, where the imaging looks inflammatory, despite the discordance with the clinical presentation. This is the so-called radiologically isolated syndrome, which can be a source of anxiety and difficulty for both patient and clinician. The evidence for its relationship to the clinically isolated syndrome and therefore to multiple sclerosis is presented, and I will describe a pragmatic approach to managing the situation.

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Isolated demyelinating syndromes: comparison of CSF oligoclonal bands and different MR imaging criteria to predict conversion to CDMS

Abstract: We observed a high prevalence of OB in CIS. OB and MR imaging (Paty's and Fazekas' criteria) have high sensitivity. Barkhof's criteria have a higher specificity. Both OB and MR imaging criteria have a high negative predictive value.

Cited by 193 publications

References 22 publications

Prognostic value of magnetic resonance imaging in patients with clinically isolated syndrome conversion to multiple sclerosis: A meta-analysis

Prognostic value of magnetic resonance imaging in patients with clinically isolated syndrome conversion to multiple sclerosis: A meta-analysis

Multipl Skleroz Prevelansı: Türkiye’nin Kuzey Doğusunda Epidemiyolojik Saha Çalışması

When confronted by a patient with the radiologically isolated syndrome

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