Isolated follicle-stimulating hormone (FSH) deficiency in two infertile men without FSH β gene mutation: Case report and literature review

Rougier, C.; Hiéronimus, S.; Panaïa‐Ferrari, Patricia; Lahlou, Najiba; Paris, Florentin; Fénichel, Patrick

doi:10.1016/j.ando.2019.06.002

Cited by 11 publications

(18 citation statements)

References 22 publications

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“…In male animals, FSH promotes seminiferous epithelial development and spermatogenesis [ 19 ]. Congenital FSH deficiency caused by the FSHB mutation could directly lead to abnormal sperm and even infertility [ 6 ]. With the emergence of recombinant FSH, more and more FSH preparations or biosimilar drugs are used in the treatment of male infertility, while the use of different FSH preparations achieved similar results in stimulating spermatogenesis in males and eventually inducing physiological pregnancy [ 20 ].…”

Section: Function and Structure Of Fshmentioning

confidence: 99%

“…In women with PCOS, it can promote follicular development by injecting an appropriate amount of exogenous FSH to supplement the low concentration of FSH caused by insufficient endogenous secretion [ 4 , 5 ]. The lack of FSH and FSHR may also cause difficulty in spermatogenesis and infertility in men [ 6 ]. Some preliminary data suggest a beneficial effect on live birth and pregnancy of gonadotrophin treatment for men with idiopathic male factor subfertility [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Advances in the Regulation of Mammalian Follicle-Stimulating Hormone Secretion

Wang

Zhang

Yuan

2021

Animals

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Mammalian reproduction is mainly driven and regulated by the hypothalamic-pituitary-gonadal (HPG) axis. Follicle-stimulating hormone (FSH), which is synthesized and secreted by the anterior pituitary gland, is a key regulator that ultimately affects animal fertility. As a dimeric glycoprotein hormone, the biological specificity of FSH is mainly determined by the β subunit. As research techniques are being continuously innovated, studies are exploring the underlying molecular mechanism regulating the secretion of mammalian FSH. This article will review the current knowledge on the molecular mechanisms and signaling pathways systematically regulating FSH synthesis and will present the latest hypothesis about the nuclear cross-talk among the various endocrine-induced pathways for transcriptional regulation of the FSH β subunit. This article will provide novel ideas and potential targets for the improved use of FSH in livestock breeding and therapeutic development.

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Section: Function and Structure Of Fshmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Advances in the Regulation of Mammalian Follicle-Stimulating Hormone Secretion

Wang

Zhang

Yuan

2021

Animals

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“…Several reproduction disorders are associated with absent or low FSH secretion, which may result from mutations of the FSHβ or in the FSHR, and from disorders unrelated to mutations, but related to the FSH signaling pathways [ 34 , 35 ]. In this regard, the condition called hypogonadism if often classified into three categories: primary hypogonadism (hypergonadotropic, resulting from a primary testicular disorder); secondary hypogonadism, which is congenital or acquired (hypogonadotropic, presenting deficiencies in the hypothalamus and/or pituitary); mixed hypogonadism (affecting both testes and the hypothalamus/pituitary).…”

Section: Introductionmentioning

confidence: 99%

Actions and Roles of FSH in Germinative Cells

Recchia

Jorge

Pessôa

et al. 2021

IJMS

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Follicle stimulating hormone (FSH) is produced by the pituitary gland in a coordinated hypothalamic–pituitary–gonadal (HPG) axis event, plays important roles in reproduction and germ cell development during different phases of reproductive development (fetal, neonatal, puberty, and adult life), and is consequently essential for fertility. FSH is a heterodimeric glycoprotein hormone of two dissociable subunits, α and β. The FSH β-subunit (FSHβ) function starts upon coupling to its specific receptor: follicle-stimulating hormone receptor (FSHR). FSHRs are localized mainly on the surface of target cells on the testis and ovary (granulosa and Sertoli cells) and have recently been found in testicular stem cells and extra-gonadal tissue. Several reproduction disorders are associated with absent or low FSH secretion, with mutation of the FSH β-subunit or the FSH receptor, and/or its signaling pathways. However, the influence of FSH on germ cells is still poorly understood; some studies have suggested that this hormone also plays a determinant role in the self-renewal of germinative cells and acts to increase undifferentiated spermatogonia proliferation. In addition, in vitro, together with other factors, it assists the process of differentiation of primordial germ cells (PGCLCs) into gametes (oocyte-like and SSCLCs). In this review, we describe relevant research on the influence of FSH on spermatogenesis and folliculogenesis, mainly in the germ cell of humans and other species. The possible roles of FSH in germ cell generation in vitro are also presented.

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“…Although FSH level was not available in this current study, it is possible that the elevation of inhibin B after acrylamide intoxication would subsequently decrease FSH. [21] However, case reports on isolated FSH deficiency instead showed normal testosterone and LH levels. [21] Moreover, although it is not clear where in the hypothalamic-pituitary axis acrylamide may affect, acrylamide may also lead to FSH over-secretion from the pituitary gland.…”

Section: Plos Onementioning

confidence: 99%

“…[21] However, case reports on isolated FSH deficiency instead showed normal testosterone and LH levels. [21] Moreover, although it is not clear where in the hypothalamic-pituitary axis acrylamide may affect, acrylamide may also lead to FSH over-secretion from the pituitary gland. Previous epidemiologic study reported acrylamide intake has been positively associated with FSH levels in pre-menopausal women.…”

Section: Plos Onementioning

confidence: 99%

Association between acrylamide exposure and sex hormones in males: NHANES, 2003–2004

et al. 2020

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Introduction Acrylamide is widely present in heat-processed food, cigarette smoke and environment. Reproductive toxicity was reported in animals treated with acrylamide, particularly in males. The reproductive toxicity of acrylamide and its active metabolite, glycidamide, was reported to be mainly mediated through DNA damage in spermatocytes. However, the effect of acrylamide on sex hormones in men is unknown. Methods There were 468 male subjects (age ≧ 12 years) enrolled to determine the relationships between hemoglobin adducts of acrylamide (HbAA) and hemoglobin adducts of glycidamide (HbGA) with several sex hormones using the National Health and Nutrition Examination Survey (NHANES), 2003 to 2004. All potential confounding variables in the data set were properly adjusted. Results We found that one unit increase in the natural log-transformed HbAA level was associated with an increase in natural log transformed serum inhibin B level by 0.10 (SE = 0.05; P = 0.046), and natural log transformed serum sex hormone binding globulin (SHBG) by 0.15 (SE = 0.15; P = 0.036). With respect to HbGA, one unit increase in the natural log-transformed HbGA level was associated with an increase in natural log transformed serum anti-Mü llerian Hormone (AMH) level by 0.31 (SE = 0.00; P = 0.003). Conclusion In this representative cohort, we identified positive associations between acrylamide exposure and several sex hormones in men. The HbAA is positively associated with inhibin B and SHBG, and HbGA is positively associated with AMH. Other than genotoxicity, our

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Isolated follicle-stimulating hormone (FSH) deficiency in two infertile men without FSH β gene mutation: Case report and literature review

Cited by 11 publications

References 22 publications

Advances in the Regulation of Mammalian Follicle-Stimulating Hormone Secretion

Advances in the Regulation of Mammalian Follicle-Stimulating Hormone Secretion

Actions and Roles of FSH in Germinative Cells

Association between acrylamide exposure and sex hormones in males: NHANES, 2003–2004

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