Isolated foot metastasis of squamous cell carcinoma of the lung: a rare location

Abstract

Squamous cell carcinoma of the lung usually presents as a local rather than a metastatic disease. We present a 55-year-old male who was referred to the orthopedics and traumatology clinic for evaluation of pain and discomfort around the left ankle 2 months after diagnosis of locally advanced non-small cell (squamous cell) lung cancer. Physical examination revealed nonspecific pain and tenderness around the ankle. T2-weighted MR images showed lesions like a bone marrow edema around the talar head and neck. Whole body dynamic bone scan revealed a metastatic lesion only in the foot. The patient died 4 months after diagnosis of the metastasis. Early diagnosis of foot metastasis may be challenging and delays in diagnosis of up to 24 months have been reported. Foot metastases are usually associated with advanced metastatic disease and survival rates are poor. Although metastatic disease of the foot is rare, it should be considered in the diagnosis of a painful foot in the elderly lung cancer patients. Palliative treatments such as pain relief medications should be chosen for patients with an expectancy of short survival whereas aggressive approaches may be applied for those with longer survival expectations.

Squamous cell carcinoma in association with a red tattoo

“…The azo pigment red 210 used in our case is listed as “not to be used” in any kind of cosmetic agent . The tumor's anatomical location was unusual, with few cases of isolated metastasis of squamous cell carcinoma of the lung described in this region .…”

Nuclear Medicine for the Orthopedic Foot and Ankle Surgeon

“…Other studies have demonstrated its utility in cases where traditional imaging, such as plain film or MRI, has been falsely negative, including patients with pigmented villonodular synovitis (PVNS) and metastatic lung cancer. 39,78…”

“…However, nuclear imaging modalities offer the ability to identify areas of pathology that may be occult on traditional imaging and, in the case of time-sensitive conditions, may provide diagnostic information days to weeks before other methods can. 39,82…”

“…However, nuclear imaging modalities offer the ability to identify areas of pathology that may be occult on traditional imaging and, in the case of time-sensitive conditions, may provide diagnostic information days to weeks before other methods can. 39,82 Nuclear imaging is defined by the injection of physiologically active radiotracer into the bloodstream followed by detection and mapping to anatomic locations for the purpose of establishing a clinical diagnosis. The first nuclear imaging techniques developed were the technetium-99m (Tc-99m) bone scan, gallium-67 (Ga-67) citrate scan, and radiolabeled leukocyte scan.…”

Plattenepithelkarzinom in Verbindung mit einer roten Tätowierung

“…Das Azopigment Red 210, das bei unserer Patientin verwendet wurde, ist als ein Stoff aufgelistet, der in Kosmetika „keinesfalls verwendet werden darf“ . Die anatomische Lokalisierung des Tumors war ungewöhnlich, wobei einige wenige Fälle isolierter Metastasen von Plattenepithelkarzinomen der Lunge in diesem Bereich beobachtet worden sind .…”