Isolated gallbladder metastasis of melanoma: Case report

Vilar, Gonzalo Guido D'Urso; Iriarte, Facundo; Speisky, Daniela; Bregante, Mariano; Quildrian, Sergio Damián

doi:10.1016/j.ijscr.2020.04.086

Cited by 11 publications

(7 citation statements)

References 13 publications

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“…Regarding sex, 67.2% of the patients were male (39 patients), whereas 32.8% were female (19 patients). The ratio between men and women was 3:1, suggesting a male predominance in the reported MMG population 6–43 …”

Section: Resultsmentioning

confidence: 95%

Role of minimally invasive surgery in the treatment of gallbladder metastatic melanoma. A review of the literature and a case report

et al. 2022

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Background: Primary and secondary gallbladder melanomas are rare, and only 58 cases have been reported in scientific literature to date. This paper aimed to explore the role of minimally invasive surgery in the management of gallbladder metastatic melanomas.Case: Herein, we present the case of a 68-year-old man with metastatic gallbladder melanoma who was treated with laparoscopic cholecystectomy. Our case management was then compared with that of other cases reported in the literature. Conclusion:Currently, metastatic melanomas can be considered as a potentially curable disease. Palliation of symptoms and fast recovery following minimally invasive procedures could be beneficial for these patients. Particularly, laparoscopic procedures appear to prolong the survival of gallbladder melanoma patients.

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Section: Resultsmentioning

confidence: 95%

Role of minimally invasive surgery in the treatment of gallbladder metastatic melanoma. A review of the literature and a case report

et al. 2022

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“…Even if the surgical approach was different (4 patients had an open surgery, 6 had a laparoscopic procedure, and 1 had an endoscopic surgery that was converted to an open procedure), it is worth mentioning that, unlike for our patient, all surgeries were carefully planned and performed with oncological precautions. Of note, only 3 of the 11 favorable post-operative outcome patients had adjuvant immunotherapy [ 13 , 15 , 17 ]. Pivotal randomized control trials have shown that adjuvant immunotherapy could significantly increase recurrence-free survival in resected stage IV melanoma patients [ 9 , 10 ], possibly improving these already favorable outcomes post gallbladder resection.…”

Section: Discussionmentioning

confidence: 99%

“…Open surgery is associated with higher morbidity but is safer regarding the risk of trocar recurrence and enables a manual exploration of the abdominal cavity, useful to reveal bowel metastatic lesions not always identifiable by preoperative imaging examinations [ 15 , 16 , 26 ]. There are too few cases to recommend a certain type of surgical approach, and decision has to be made on an individual basis, based on patient’s clinical status and disease extension.…”

Section: Discussionmentioning

confidence: 99%

Trocar Site Recurrence after Laparoscopic Cholecystectomy for Unsuspected Isolated Gallbladder Metastasis of Melanoma: A Case Report and Review of the Literature

Sergeant,

Kerger,

Drowart

et al. 2023

Case Rep Oncol

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Cutaneous melanoma can metastasize to almost any organ, including in-transit metastases, lymph nodes, liver, lungs, brain, and bones. Spread to the gastrointestinal tract is less common and generally concerns the small bowel, colon, and stomach. Gallbladder involvement is rarer, and only few cases describe it as the sole site of metastasis upon diagnosis. Melanoma metastases to the gallbladder are usually detected on staging or surveillance imaging, as patients usually show few or no symptoms. In resectable stage IV melanoma patients, complete surgical resection appears to improve the prognosis. However, due to the rarity of isolated gallbladder metastasis of melanoma, there are no guidelines regarding the optimal surgical approach (endoscopic or open cholecystectomy). Here, we report the case of isolated gallbladder melanoma metastasis found after laparoscopic cholecystectomy performed in a 46-year-old female patient with no known history of cancer presenting with acute cholecystitis symptoms. Six weeks after surgery, the patient developed trocar site recurrence. This case highlights the importance of a planned and open surgery for resectable melanoma metastases rather than a laparoscopic approach.

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“…Finally, positivity at fluorodeoxyglucose PET scan may show the occurrence of unsuspected metastatic sites and help in differential diagnosis of gallbladder lesions. Due to the rarity of this condition, no therapeutic guidelines have yet been proposed, but evidences show that patients with solitary melanoma metastasis to the gallbladder may benefit from resection of the lesion with improved quality of life and survival [ [19] , [20] , [21] , [22] ]. Surgical treatment is indicated considering the extension of the disease and the clinical status of the patient [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Malignant metastatic melanoma to the gallbladder: Report of a peculiar case

Buono

Maienza

Rinaldi

et al. 2020

International Journal of Surgery Case Reports

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Highlights Melanoma is one of the most aggressive and one of the fastest growing types of cancer. The gallbladder envolvement from a metastatic cutaneous malignant melanoma is a highly uncommon finding, usually associated with diffuse metastatic disease and observed during autopsy. We report a case of a 35-years old Caucasian woman with isolated metastasis of gallbladder form cutaneous primary malignant melanoma underwent to laparoscopic cholecystectomy. Malignant cutaneous melanoma is a skin cancer characterized by the highest mortality. Isolated metastasis of gallbladder are barely described and mostly present in a widespread metastatic disease. Surgical treatment is indicated considering the extension of the disease and the clinical status of the patient.

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Isolated gallbladder metastasis of melanoma: Case report

Cited by 11 publications

References 13 publications

Role of minimally invasive surgery in the treatment of gallbladder metastatic melanoma. A review of the literature and a case report

Role of minimally invasive surgery in the treatment of gallbladder metastatic melanoma. A review of the literature and a case report

Trocar Site Recurrence after Laparoscopic Cholecystectomy for Unsuspected Isolated Gallbladder Metastasis of Melanoma: A Case Report and Review of the Literature

Malignant metastatic melanoma to the gallbladder: Report of a peculiar case

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