Isolated hyperpigmentation of the oral mucosa due to hydroxychloroquine

Kalampalikis, Andreas; Goetze, Steven; Elsner, Peter

doi:10.1111/j.1610-0387.2012.08055.x

Cited by 14 publications

(21 citation statements)

References 4 publications

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“…Diffuse oral mucosal pigmentations may be a physiologic racial trait or may be due to various conditions, such as smoking, drugs, inflammatory processes, Laugier-Hunziker syndrome or systemic diseases, including Peutz-Jeghers syndrome, Leopard syndrome, Carney complex syndrome, McCune-Albright syndrome and adrenal gland dysfunction [1][2][3].…”

Section: Discussionmentioning

confidence: 99%

Oral mucosal hyperpigmentation in a patient with a previous diagnosis of melanoma of the scalp

Altobrando

Tabanelli

Crisanti

et al. 2020

J Deutsche Derma Gesell

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Section: Discussionmentioning

confidence: 99%

Oral mucosal hyperpigmentation in a patient with a previous diagnosis of melanoma of the scalp

Altobrando

Tabanelli

Crisanti

et al. 2020

J Deutsche Derma Gesell

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“…Most commonly, its use can result in hyperpigmentation of the forehead, hard palate, forearms, and shins [2, 3]; it can also cause pigmentation that appears on the cheek mucosa and nails [6, 11]. The development of hydroxychloroquine-associated cutaneous dyschromia is not so rare and can present as black, blue-gray or blue discoloration in photodistributed areas or skin sites protected from the sun [6].…”

Section: Discussionmentioning

confidence: 99%

Hydroxychloroquine-Associated Hyperpigmentation Mimicking Elder Abuse

Cohen

2013

Dermatol Ther (Heidelb)

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BackgroundHydroxychloroquine may result in cutaneous dyschromia. Older individuals who are the victims of elder abuse can present with bruising and resolving ecchymoses.PurposeThe features of hydroxychloroquine-associated hyperpigmentation are described, the mucosal and skin manifestations of elder abuse are reviewed, and the mucocutaneous mimickers of elder abuse are summarized.Case ReportAn elderly woman being treated with hydroxychloroquine for systemic lupus erythematosus developed drug-associated black and blue pigmentation of her skin. The dyschromia was misinterpreted by her clinician as elder abuse and Adult Protective Services was notified. The family was eventually cleared of suspected elder abuse. A skin biopsy of the patient’s dyschromia confirmed the diagnosis of hydroxychloroquine-associated hyperpigmentation.ConclusionHyperpigmentation of skin, mucosa, and nails can be observed in patients treated with antimalarials, including hydroxychloroquine. Elder abuse is a significant and underreported problem in seniors. Cutaneous findings can aid in the discovery of physical abuse, sexual abuse, and self-neglect in elderly individuals. However, medication-associated effects, systemic conditions, and accidental external injuries can mimic elder abuse. Therefore, a complete medical history and appropriate laboratory evaluation, including skin biopsy, should be conducted when the diagnosis of elder abuse is suspected.

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“…Ello permite evaluar un eventual potencial de malignizació n, así como elegir el tratamiento má s adecuado. En cada caso, deberá realizarse un aná lisis sistemá tico, que incluya la historia clínica pormenorizada y un examen completo del 30 , asintomá ticas, 25-31% fumadores 2,31 , en meses/añ os tras deshabituació n suele remitir hiperpigmentació n 1,31 Clínica y antecedentes tabá quicos…”

Section: Discusió Nunclassified