Isolated idiopathic bile ductular hyperplasia in patients with persistently abnormal liver function tests

Sonzogni, Aurelio; Colloredo, Guido; Fabris, Luca; Cadamuro, Massimiliano; Paris, Bruno; Roffi, Luigi; Pozzi, Massimo; Bovo, Giorgio; Poggio, P. Del; Portmann, Bernard; Strazzabosco, Mario

doi:10.1016/j.jhep.2003.12.019

Cited by 22 publications

(9 citation statements)

References 27 publications

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“…CD10 stains several normal tissues and tumours. This antigen is an established marker for hepatocytes 15,16 in the liver, as is EMA for interlobular bile ducts 20 …”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical classification of ductular reactions in human liver

et al. 2010

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“…CD10 stains several normal tissues and tumours. This antigen is an established marker for hepatocytes 15,16 in the liver, as is EMA for interlobular bile ducts 20 …”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical classification of ductular reactions in human liver

et al. 2010

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“…All of these markers have already been mentioned in connection with the hepatic progenitor cell compartment. Atypical ductular reactions have been reported EMA−/CD56+, while the typical ones, which are similar to the interlobular bile ducts, are EMA+/CD56− [33]. CD56 has been demonstrated in proliferating ductules, while it could not be observed in normal canals of Hering [34,35], but recent studies found CD56 mRNA and protein in ductules of normal human livers [36,37].…”

Section: Discussionmentioning

confidence: 99%

Architectural and Immunohistochemical Characterization of Biliary Ductules in Normal Human Liver

Dezső

Paku

Papp

et al. 2009

Stem Cells and Development

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The canals of Hering or biliary ductules have been described to connect the bile canaliculi with the interlobular bile ducts, and thus forming the distal part of the biliary tree. Studies in the last two decades suggested that the cells constructing these ductules could behave as hepatic progenitor cells. The canals of Hering are confined to the periportal space in the rat, while they have been reported to spread beyond the limiting plate in human liver. The distribution of the distal biliary ductules in normal human hepatic tissue has been investigated in our recent experiments. We could demonstrate the presence of interlobular connective tissue septa in a rudimentary form in healthy livers. The canals of Hering run in these septa in line with the terminal branches of the portal vein and hepatic arteries. This arrangement develops in the postnatal period but regresses after early childhood. The canals of Hering can be identified by the unique epithelial membrane antigen (EMA)-/CD56+/CD133+ immunophenotype. The canals of Hering leave the periportal space and spread into the liver parenchyma along rudimentary interlobular septa outlining the hepatic lobules. Our observations refine the original architectural description of the intraparenchymal portion of the canals of Hering in the human liver. The distinct immunophenotype supports their unique biological function.

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“…Careful histological studies have also led to refinements of our understanding of the microanatomy of the finer branches of the biliary tree, emphasizing for instance that bile ductules may traverse the limiting plate and could be found within the hepatic parenchyma [4][5][6][7]. Other human tissue studies have elucidated the dynamics and the progenitor cell characteristics of these biliary ductules in several liver diseases, including hepatocellular and cholangiocytic damage as well as hepatic neoplastic conditions [8][9][10][11][12][13][14]. In a previous study we have shown that decreased numbers and an insufficient proliferative response of these bile ductules contributed to bile duct loss in chronic rejection of human liver allografts [15].…”

Section: Introductionmentioning

confidence: 99%