Isolated Infiltrative Optic Neuropathy in an Acute Lymphoblastic Leukemia Relapse

Kuan, Huey Chuin; Mustapha, Mushawiahti; Mohamed, Shelina Oli; Aziz, Roslin Azni Abdul; Loh, C Khai; Mohammed, Faten F.; Naffi, Ainal Adlin; Othman, Othmaliza; Nasaruddin, Rona Asnida; Alias, Hamidah

doi:10.7759/cureus.25625

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…The optic disc presents as pale and swollen with blurred margins, and may be accompanied by hemorrhages [ 52 ]. Optic nerve infiltration is frequent in children affected by acute leukemias and should rain concern for CNS involvement [ 54 , 55 , 56 ].…”

Section: Secondary Disease Involvementmentioning

confidence: 99%

Ophthalmic Manifestations in Patients with Blood Malignancies

Rossi,

Buizza,

Alessio

et al. 2024

Hematology Reports

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Ocular complications can occur in up to 90% of patients with blood malignancies. Such complications range from direct infiltration to local hemostatic imbalance and treatment-related toxicity. This narrative review is based on a systematic computerized search of the literature conducted until January 2024 and examines the common ocular complications associated with blood cancers. Ocular complications from primary disease include mass effects from ocular adnexal lymphomas and intraocular lymphomas, with B-cell lymphomas accounting for 95% of primary ocular presentations. Secondary disease involvement from systemic hematological malignancies can lead to a wide range of ocular manifestations, such as leukemic retinopathy. Furthermore, toxicity from antineoplastic therapies and ocular graft versus host disease (oGVHD) after hematopoietic stem cell transplantation present additional risks to ocular health. In conclusion, ocular complications in blood cancer patients are an integral part of patient management, requiring regular ophthalmic evaluations and close collaboration between oncologists and ophthalmologists. Advances in therapy and an increased focus on early symptom recognition are essential for preserving vision and enhancing patient quality of life.

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Section: Secondary Disease Involvementmentioning

confidence: 99%

Ophthalmic Manifestations in Patients with Blood Malignancies

Rossi,

Buizza,

Alessio

et al. 2024

Hematology Reports

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“…Infiltrative processes of the optic nerve likewise generate RGC degeneration. An example is the leukemic optic neuropathy, mainly associated with acute lymphoblastic leukemia [544][545][546]. The involvement of the optic nerve in leukemic cases remains, however, a rare circumstance, which may mostly appear in relapses and late in the disease course [547,548].…”

Section: Infiltrative Optic Neuropathiesmentioning

confidence: 99%

Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?

Buonfiglio,

Böhm,

Pfeiffer

et al. 2023

Antioxidants

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Optic nerve disorders encompass a wide spectrum of conditions characterized by the loss of retinal ganglion cells (RGCs) and subsequent degeneration of the optic nerve. The etiology of these disorders can vary significantly, but emerging research highlights the crucial role of oxidative stress, an imbalance in the redox status characterized by an excess of reactive oxygen species (ROS), in driving cell death through apoptosis, autophagy, and inflammation. This review provides an overview of ROS-related processes underlying four extensively studied optic nerve diseases: glaucoma, Leber’s hereditary optic neuropathy (LHON), anterior ischemic optic neuropathy (AION), and optic neuritis (ON). Furthermore, we present preclinical findings on antioxidants, with the objective of evaluating the potential therapeutic benefits of targeting oxidative stress in the treatment of optic neuropathies.

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“…Infiltrative processes of the optic nerve likewise generate RGC degeneration. An example is the leukemic optic neuropathy, mainly associated with acute lymphoblastic leukemia [541][542][543]. Involvement of the optic nerve in leukemic cases remains anyway a rare circumstance, which may mostly appear in relapses and late in the disease course [544,545].…”

Section: Infiltrative Optic Neuropathiesmentioning

confidence: 99%

Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?

Buonfiglio,

Böhm,

Pfeiffer

et al. 2023

Preprint

View full text Add to dashboard Cite

Optic nerve disorders encompass a wide spectrum of conditions characterized by the loss of retinal ganglion cells (RGCs) and subsequent degeneration of the optic nerve. The etiology of these disorders can vary significantly, but emerging research highlights the crucial role of oxidative stress, an imbalance in the redox status characterized by an excess of reactive oxygen species (ROS), in driving cell death through apoptosis, autophagy, and inflammation. This review provides an overview of ROS-related processes underlying four extensively studied optic nerve diseases: glaucoma, Leber's hereditary optic neuropathy (LHON), anterior ischemic optic neuropathy (AION), and optic neuritis (ON). Furthermore, we present preclinical findings on antioxidants, with the objective of evaluating the potential therapeutic benefits of targeting oxidative stress in the treatment of optic neuropathies.

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Isolated Infiltrative Optic Neuropathy in an Acute Lymphoblastic Leukemia Relapse

Cited by 4 publications

References 21 publications

Ophthalmic Manifestations in Patients with Blood Malignancies

Ophthalmic Manifestations in Patients with Blood Malignancies

Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?

Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?

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