Isolated Interrupted Aortic Arch: Unexpected Diagnosis in a 63-Year-Old Male

Javadzadegan, Hassan; Porhomayon, Jahan; Sadighi, Alireza; Yavarikia, Mehrdad; Nader, Nader D.

doi:10.1155/2011/989621

Cited by 7 publications

(17 citation statements)

References 10 publications

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“…The patent ductus arteriosus has to continue as descending aorta otherwise lower body perfusion is compromised. 3,9 Bicuspid aortic valve and right subclavian artery abnormalities may also be seen in these patients. 1 Other associated rare cardiovascular anomalies include truncus arteriosus, singleventricle pathologies, atrioventricular canal defects and transposition of great arteries.…”

Section: Discussionmentioning

confidence: 92%

“…11 Especially in the Type B interrupted aortic arch, genetic testing is suggested due to high association with DiGeorge Syndrome. 3 The affected patients rarely reach adulthood without surgical treatment. In these patients, the main factor of the survival is the extensive collateral vessels that provide distal blood flow.…”

Section: Discussionmentioning

confidence: 99%

“…1 The pathology may be divided into three subtypes based on the location of the interruption such as Types A, B or C as the interruption distal to the left subclavian artery, the interruption distal to the origin of the left carotid artery and proximal to the origin of the left carotid artery, respectively. 3 The most common type is Type B with an incidence of 53% among cases followed by Type A (43%) and Type C (4%). 2 The most common presentation of the patients is severe congestive heart failure in the neonatal period, 4 and without treatment, the pathology may end up with mortality in 90% of patients at a median age of 4 days.…”

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confidence: 99%

“…2 The most common presentation of the patients is severe congestive heart failure in the neonatal period, 4 and without treatment, the pathology may end up with mortality in 90% of patients at a median age of 4 days. 3,5 Surgery is the main treatment option for the patients with interrupted aortic arch. Various techniques were defined in the literature such as direct end-toend anastomosis, use of an anterior patch at the anastomosis site and extensive mobilisation of the descending aorta or prosthetic graft interposition, with pros and cons related with each technique.…”

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Off-pump ascending aorta or aortic arch to descending aorta bypass with a pericardial roll for the treatment of critically ill infants with interrupted aortic arch

et al. 2020

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Aim: Standard surgical treatment of the interrupted aortic arch with the use of cardiopulmonary bypass is risky especially in critically ill babies. In this manuscript, we present the results of off-pump pericardial roll bypass for the treatment of aortic interruption. Material and methods: The technique was applied in nine critically ill infants between July 2011 and December 2019. Data were reviewed retrospectively. There were four girls and five boys. The types of the interruption were type B in six cases and type A in three babies. Additional cardiovascular anomalies were ventricular septal defect in all, atrial septal defect or patent foramen ovale in all, single-ventricle pathologies in two and bicuspid aortic valve in three cases. All the patients were in critical situations such as intubated, having symptoms of infection, congestive heart failure or ischaemia and malperfusion leading visceral organ dysfunction. Results: All patients underwent off-pump ascending aorta or aortic arch to descending aorta bypass with a pericardial roll. Post-operative early mortality occurred in one patient with severe mitral regurgitation due to cardio-septic shock. One patient who had single-ventricle pathology underwent bidirectional Glenn and was lost on the post-operative 26th day due to sepsis 2 years after operation. Two patients presented with dilatation of the pericardial tube 18 and 24 months after the operations and one underwent reconstruction of the neo-arch. The remaining patients are asymptomatic, active and within normal limits of body and mental growth. Conclusion: Treatment of interrupted aortic arch with a bypass with an autologous pericardial roll treated with gluteraldehyde without cardiopulmonary bypass seems a safe and reliable technique especially for the treatment of critically ill infants.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Off-pump ascending aorta or aortic arch to descending aorta bypass with a pericardial roll for the treatment of critically ill infants with interrupted aortic arch

et al. 2020

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“…Type A which is interruption distal to the origin of left subclavian artery (LSA), Type B which is interruption between left common carotid and LSA and Type C which is interruption between brachiocephalic trunk and left common carotid artery,4 …”

Section: Discussionmentioning

confidence: 99%

Interrupted aortic arch complicated with takotsubo cardiomyopathy mimicking aortic dissection

Baloch¹,

Tai

Khan

et al. 2017

BMJ Case Reports

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A 50-year-old man presented to the emergency department with interscapular pain, diaphoresis and restlessness. Initial examination raised the possibility of aortic dissection; however, the CT scan did not concur with the diagnosis. An ECG showed ST segment elevation in leads V1-V6 and echocardiography showed severe left ventricular systolic dysfunction. Coronary angiography through the right femoral artery was attempted but the diagnostic catheter could not be advanced to the ascending aorta. Radiocontrast injection showed complete obstruction of the descending aorta. Coronary angiography through right radial approach showed mild left anterior descending disease. The aortogram showed complete interruption of the ascending aorta with extensive collateral network. Left ventricle gram was consistent with stress-induced cardiomyopathy. We noticed intermittent confusion and agitation. MRI of the brain showed areas of deep white matter ischaemia as well as microhaemorrhages, suggesting posterior reversible leucoencephalopathy syndrome. He unfortunately went into cardiac arrest and could not be revived.

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An evolution-based DNA-binding residue predictor using a dynamic query-driven learning scheme

et al. 2016

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DNA-binding proteins play a pivotal role in various biological activities. Identification of DNA-binding residues (DBRs) is of great importance for understanding the mechanism of gene regulations and chromatin remodeling. Most traditional computational methods usually construct their predictors on static non-redundant datasets. They excluded many homologous DNA-binding proteins so as to guarantee the generalization capability of their models. However, those ignored samples may potentially provide useful clues when studying protein-DNA interactions, which have not obtained enough attention. In view of this, we propose a novel method, namely DQPred-DBR, to fill the gap of DBR predictions. First, a large-scale extensible sample pool was compiled. Second, evolution-based features in the form of a relative position specific score matrix and covariant evolutionary conservation descriptors were used to encode the feature space. Third, a dynamic query-driven learning scheme was designed to make more use of proteins with known structure and functions. In comparison with a traditional static model, the introduction of dynamic models could obviously improve the prediction performance. Experimental results from the benchmark and independent datasets proved that our DQPred-DBR had promising generalization capability. It was capable of producing decent predictions and outperforms many state-of-the-art methods. For the convenience of academic use, our proposed method was also implemented as a web server at .

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Isolated Interrupted Aortic Arch: Unexpected Diagnosis in a 63-Year-Old Male

Cited by 7 publications

References 10 publications

Off-pump ascending aorta or aortic arch to descending aorta bypass with a pericardial roll for the treatment of critically ill infants with interrupted aortic arch

Off-pump ascending aorta or aortic arch to descending aorta bypass with a pericardial roll for the treatment of critically ill infants with interrupted aortic arch

Interrupted aortic arch complicated with takotsubo cardiomyopathy mimicking aortic dissection

An evolution-based DNA-binding residue predictor using a dynamic query-driven learning scheme

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