Isolated Intracranial Sinus Histiocytosis—Rosai Dorfman Disease: Report of Two Cases

Beroš, Vili; Čupić, Hrvoje; Stipić, Darko; Žarković, Kamelija; Rotim, Krešimir

doi:10.1055/s-0035-1566428

Cited by 1 publication

(7 citation statements)

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“…However, sometimes it can lead to rapid tumor growth after several years, even decades. Even fatal cases have been described in adult population [1,15]. Intracranial RDD may occur in the suprasellar region, convexity, parasagittal region, cavernous sinus, petroclival region, and cerebellum [15].…”

Section: Localization and Clinical Features Of Extranodal Intracraniamentioning

confidence: 99%

“…Definitive diagnosis is made based on the specific changes in the histopathological evaluation. Histological findings typically show emperipolesis of affected histiocytes or hyperplastic lymph node sinuses containing enlarged histiocytes with phagocyted intact lymphocytes [4,15]. Specific immunoassay findings include positive S100 and CD68 staining and negative CD1a staining of the characteristic histiocytic non-Langerhans cells [10,15].…”

Section: Introductionmentioning

confidence: 99%

“…Histological findings typically show emperipolesis of affected histiocytes or hyperplastic lymph node sinuses containing enlarged histiocytes with phagocyted intact lymphocytes [4,15]. Specific immunoassay findings include positive S100 and CD68 staining and negative CD1a staining of the characteristic histiocytic non-Langerhans cells [10,15]. Additional findings include variable CD163 and CD14 positivity [1,14,15].…”

Section: Introductionmentioning

confidence: 99%

“…Specific immunoassay findings include positive S100 and CD68 staining and negative CD1a staining of the characteristic histiocytic non-Langerhans cells [10,15]. Additional findings include variable CD163 and CD14 positivity [1,14,15].…”

Section: Introductionmentioning

confidence: 99%

“…Extranodal structures are affected in around 43% of patients and include central nervous system (CNS), skin, gastrointestinal and respiratory tract, heart, and other [1,4,10,17,18]. Only five to ten percent patients have RDD of the CNS; intraspinal lesions are less common than intracranial lesions [1,4,15,17]. Intracranial disease tends to occur in adult patients, slightly older than RDD in general [19].…”

Section: Introductionmentioning

confidence: 99%

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Extranodal Intracranial Rosai-Dorfman-Destombes Disease in Children: a Literature Review

Trbojević¹,

Marić

Barišić

2020

SN Compr. Clin. Med.

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Rosai-Dorfman-Destombes (RDD) disease also known as sinus histiocytosis with massive lymphadenopathy is a rare disease characterized by disorder of histiocytes within lymph nodes or other affected tissues. Extranodal forms of disease are even more uncommon. Only small percent of patients present with intracranial extranodal form of disease. Lesion biopsy and characteristic histopathological findings are crucial for definitive diagnosis. Histological findings typically show emperipolesis of affected histiocytes or hyperplastic lymph node sinuses containing enlarged histiocytes with phagocyted intact lymphocytes with specific immunoassay findings of the characteristic histiocytic non-Langerhans cells. Therapy includes various modalities such as surgery, steroids, radiotherapy, and/or chemotherapy. In case of extranodal intracranial form of disease, resection (single or combined with other treatment) was reported as effective. There are only few cases of extranodal intracranial disease in pediatric population described in the world so far. We aimed to provide brief comprehensive review of published cases referring on pediatric extranodal intracranial RDD.

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Section: Localization and Clinical Features Of Extranodal Intracraniamentioning

confidence: 99%