Isolated late asthmatic reaction due to nickel sulphate without antibodies to nickel

Malo, Jean‐Luc; Cartier, André; Gagnon, G.; Evans, Susan; Dolovich, J.

doi:10.1111/j.1365-2222.1985.tb02261.x

Cited by 47 publications

(25 citation statements)

References 12 publications

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“…Case reports [18][19][20][21] of occupational asthma due to nickel exposure have been published since McConnell et al [24] first described an asthmatic patient in a metal plating plant. Malo et al [18 21] reported two cases of positive bronchial provocation tests following inhalation of NiSO4.…”

Section: Discussionmentioning

confidence: 99%

“…developed a positive reaction to Ni-HSA. while the other did not [18][19][20][21]. Further evidence for the binding nature of this serum came from elaborate studies done by the same researchers, in which the patient's serum was shown to selectively bind to *' -' Ni [20.21 ].…”

Section: Discussionmentioning

confidence: 99%

“…Positive skin tests were present in six subjects with a strong correlation between RAST counts and mean weal diameters following administration of NiSO4: the serum of only one subject (case 7) was negative in the Ni-HSA RAST. This was not unexpected since an allergy skin test result is not always consistent with that of the Ni-HSA RAST [18,19].…”

Section: Discussionmentioning

confidence: 99%

“…Ni-HSA RAST was done using the method recommended by Malo et al for nickel sensitivity [18][19][20][21]. The radioactivity of each tube was determined using an automatic y-counter (Micromedic System Co... Philadelphia, PA, U.S.A.) as counts per minute (c.p.m.).…”

Section: Specific Ige Antibodies To Nickel Conjugated Human Serum Almentioning

confidence: 99%

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Specific IgE antibodies to nickel in workers with known reactivity to cobalt

Shirakawa

Kusaka

Morimoto

1992

Clin Experimental Allergy

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Twenty-one workers with hard metal asthma, including eight atopics, diagnosed on the basis of peak flow diaries and positive reaction to cobalt chloride (CoCl2) and/or nickel sulphate (NiSO4) in skin and provocation tests were studied for sensitization by detection of specific antibodies to nickel-conjugated human serum albumin (Ni-HSA), and nickel-conjugated exchange resin (Ni-resin). Their results were compared with those of sera obtained from control sera from 60 asthmatic patients and pair-matched asymptomatic control workers in the hard metal plant. In the RASTs (radioallergosorbent tests), sera from the same six subjects developed positive reactions both to Ni-HSA (RAST index greater than 2.0, P less than 0.01) and Ni-resin (RAST index greater than 2.0, P less than 0.01), while the counts measured for the others of the 15 subjects (RAST index less than 1.52) were about the same as those for control groups (RAST index less than 1.58). Subject HSA RAST and resin RAST results (378 +/- 52 c.p.m. in HSA RAST and 324 +/- 56 in the resin RAST) were about the same as those of the control sera (388 +/- 65 c.p.m. and 398 +/- 59 c.p.m., respectively). There was no difference in the prevalence of smoking habit and high IgE between Ni-RAST positive and negative subjects. However, subjects with simultaneous sensitivity to nickel and/or cobalt still developed asthmatic attacks following medications, while those without sensitivity to these metals were almost symptom free. The positive sera had simultaneous sensitivity to both cobalt and nickel, suggesting the presence in them of specific IgE antibodies to nickel playing some role in the aetiology of hard metal asthma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Specific Ige Antibodies To Nickel Conjugated Human Serum Almentioning

confidence: 99%

See 2 more Smart Citations

Specific IgE antibodies to nickel in workers with known reactivity to cobalt

Shirakawa

Kusaka

Morimoto

1992

Clin Experimental Allergy

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“…Spirometry was repeated at one and five minutes after exposure. If the fall in FEVI was less than 15% from the baseline, the subject was asked to continue welding for another 15 minutes. The test was discontinued if the subject complained of any respiratory discomfort.…”

Section: Welding Challenge Testmentioning

confidence: 99%

Bronchial reactions to exposure to welding fumes.

Contreras

Chan‐Yeung

1997

Occup Environ Med

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Objective-To study the Subjects and methods SUBJECTSSix welders who attended the University of British Columbia Respiratory Clinic for respiratory symptoms between November 1992 to July 1993 were invited to take part in this study. They were all full time manual arc welders. One welder (subject 6) had worked in pulpmills and was "gassed" on several occasions several years after the onset of respiratory symptoms. The remaining five welders did not give a history of being gassed. Subjects 3, 5, and 6 gave a history compatible with metal fume fever in the past.This study was approved by our institution's review board for human studies. All subjects gave written informed consent. SEQUENCE OF TESTINGVisit 1 Interview with skin prick test with common allergens and methacholine challenge test.Visit 2 Manual arc welding on mild steel as a control test. Visit 3Manual arc welding on stainless or galvanised steel. The metal selected for testing was the one that provoked symptoms in the subject tested.All challenge tests (non-specific and specific) were carried out when the subject's asthma was under control and the diurnal variation in peak expiratory flow was less than 10%. They were performed at least one week apart and at the same time of day. The patients were told not to take bronchodilators for at least six hours before challenge testing. They were allowed to continue using inhaled steroids in the same way as before. For the two subjects who had a positive bronchial reaction to a welding challenge test to galvanised metal, skin prick test, patch test, and a challenge test with the salt of the suspected metal were also carried out. ALLERGY SKIN TESTSAllergy skin prick tests were carried out with a battery of 25 common allergens and normal saline and histamine (1 mg/ml) were used as negative and positive controls respectively. A weal diameter 3 mm or greater than the negative control 15 minutes after testing was considered to be a positive reaction.

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Nickel und Nickelverbindungen [MAK Value Documentation in German language, 2008]

2012

The MAK‐Collection for Occupational Health and Safety

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Isolated late asthmatic reaction due to nickel sulphate without antibodies to nickel

Cited by 47 publications

References 12 publications

Specific IgE antibodies to nickel in workers with known reactivity to cobalt

Specific IgE antibodies to nickel in workers with known reactivity to cobalt

Bronchial reactions to exposure to welding fumes.

Nickel und Nickelverbindungen [MAK Value Documentation in German language, 2008]

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