Isolated, localised extragenital bullous Lichen sclerosus et atrophicus: A rare entity

Khatu, Swapna S; Vasani, Resham

doi:10.4103/0019-5154.117351

Cited by 9 publications

(6 citation statements)

References 7 publications

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“…reported a case of hemorrhagic bullous lesion remission with hyperkeratotic lesions after two months of treatment with high-potency topical corticosteroids [ 3 ]. Khatu and Vasani reported a patient whose bullous lesions healed with post-inflammatory hypopigmentation and scarring following a short course of oral corticosteroid and topical clobetasol dipropionate 0.05% cream with tacrolimus ointment (0.1%) [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Dermal Hemorrhage: A Clue to Lichen Sclerosus et Atrophicus

Phan

Sou

Sannaa

et al. 2020

Cureus

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Lichen sclerosus et atrophicus (LSA) may present in a rare bullous and hemorrhagic form that is often difficult to recognize both clinically and histopathologically. Clinically, the lesions may be characterized by atrophic and ivory-white sclerotic plaques in both genital and extragenital regions. Histologically, fully developed lesions of LSA are characterized by a thinned, effaced epidermis with interface change, a wide band of hyalinization in the upper dermis, and a lymphohistiocytic infiltrate below the hyalinized area. Extensive vacuolar degeneration weakens the integrity of the dermoepidermal junction, which contributes to the development of marked edema in the papillary dermis and subepidermal vesiculation. With increased fragility of dermal capillaries, hemorrhage can accumulate within the bullae. Recognizing prominent upper dermal hemorrhage as a secondary change may lead to a prompt diagnosis of LSA. We present a case of extragenital LSA that mimics a dermal hemorrhage clinically and histologically in a 71-year-old Caucasian woman.

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Section: Discussionmentioning

confidence: 99%

Dermal Hemorrhage: A Clue to Lichen Sclerosus et Atrophicus

Phan

Sou

Sannaa

et al. 2020

Cureus

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“…Although often asymptomatic, pruritus can be reported. Like in LS, as the bullous lesions progress there is atrophy and wrinkling of the skin, and blisters may heal with milia formation . There has been no reported increased risk of malignant transformation in extragenital LS.…”

Section: Discussionmentioning

confidence: 99%

An intertriginous blistering eruption

et al. 2019

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A 66-year-old man presented with a 10-month history of erythematous blistering lesions in his axillae and groin. This eruption had begun when he was on holiday in the Caribbean, where he developed purpuric patches in the intertriginous areas. These then blistered within hours, leaving 'tissue paper-like' skin. The lesions were otherwise asymptomatic. His only longterm medication was co-tenidone for hypertension. He had no prior history of photosensitivity, excess alcohol intake, liver or autoimmune disease, or any relevant family history.On physical examination, macerated erythematous blistered areas were seen in the groin and axillae, with signs of atrophic wrinkled skin in the perinatal cleft, back and posterior legs. Nikolsky sign was negative ( Fig. 1a-d). There were no clinical changes noted on the oral and genital mucosae. The hair and nails were normal. Swabs, fungal cultures and Borrelia serology were negative. Figure 2 (a) Skin biopsy from affected skin of the patient showing hyperkeratosis, focal interface change and a subepidermal split. (b,c) Dermal hyalinization with subjacent perivascular lymphoid infiltrate. Haematoxylin and eosin; original magnification (a) 9 20; (b) 9 200; (c) 9 400. Clinicopathological case ª

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“…Le prurit est inconstant. Des formes cliniques blaschkolinéaire et bulleuse ont été décrites [ 3 , 4 ]. Le diagnostic repose sur l´histologie cutanée qui révèle une atrophie de l´épithélium malpighien avec horizontalisation de la basale, une hyperkératose folliculaire, et surtout la présence d´une bande sous épithéliale faite de collagène fibreux ou œdémateux au niveau du derme superficiel, dépourvue de fibres élastiques à la coloration à l´orcéïne [ 5 ].…”

Section: Discussionunclassified