Isolated low HDL cholesterol: an insulin-resistant state only in the presence of fasting hypertriglyceridemia.

Tai, E. Shyong; Emmanuel, S C; Chew, Suok Kai; Tan, B Y; Tan, Chek Tien

doi:10.2337/diabetes.48.5.1088

Cited by 49 publications

(28 citation statements)

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“…Thus, insulin resistance was found in both isolated hypertriglyceridemia and hypertriglyceridemia with low HDL cholesterol. This finding fits some previous studies such as Tai et al (1999) who found that isolated low HDL cholesterol was an insulin-resistant state only in the presence of fasting hypertriglyceridemia 23) . Schmidt et al (1999) commented that the lipid pattern of high triglyceride and low HDL cholesterol was a feature of inflammation and they argued that insulin resistance was due to related inflammatory cytokines 24) .…”

Section: Discussionsupporting

confidence: 80%

Isolated Hypertriglyceridemia: An Insulin-Resistant State with or without Low HDL Cholesterol

Al-Mahmood

Ismail

Rashid

et al. 2006

JAT

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There are numerous reports on insulin resistance in subjects with hypertriglyceridemia but most of the studies involved obese or diabetic subjects. We were interested to study such events but in a population free from other confounders influencing insulin sensitivity (i.e., obesity, glucose intolerance and hypertension). From the population of a cross-sectional study we obtained 12 subjects with isolated hypertriglyceridemia and compared their insulin sensitivity with that of normolipidemic subjects in that study. Insulin sensitivity and secretory status were computed using homeostasis model assessment (HOMA) software. The insulin sensitivity of hypertriglyceridemic subjects was found to be lower than in normolipidemic subjects. For the hypertriglyceridemic subjects, insulin sensitivity (HOMA%S) was 60.07% (values adjusted for age, BMI, waist circumference, and cholesterol levels), which was substantially lower than that of normolipidemic subjects (150.03%; p 0.001). The insulin secretory status (HOMA%B) of the two groups was 248.17% and 124.63%, respectively, and significantly different (p 0.001). Relative insulin resistance, HOMA-IR, of the two groups was 4.90 and 1.54, respectively. We therefore concluded that in comparison with normolipidemic subjects, the insulin sensitivity of otherwise healthy non-obese hypertriglyceridemic subjects was lower, and that B cells had to work harder to compensate for the lowered insulin sensitivity.

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Section: Discussionsupporting

confidence: 80%

Isolated Hypertriglyceridemia: An Insulin-Resistant State with or without Low HDL Cholesterol

Al-Mahmood

Ismail

Rashid

et al. 2006

JAT

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“…After adjustment for the differences in height and weight between LBW and NBW subjects, the diastolic blood pressure (DBP) was significantly higher in the LBW subjects (PZ0.01). There was no difference in the BMI or skinfold thickness between the two groups, and in general, all participants were healthy with total cholesterol, LDL-cholesterol and blood pressure measurements within the normal range, except for a mean low HDL-cholesterol level, which was present in both groups and is a common phenomenon in the Indian population (19). In our study, the subjects were not recruited according to gestational age, a factor that has previously been demonstrated to represent a reason for risk (i.e.…”

Section: Resultsmentioning

confidence: 98%

Born with low birth weight in rural Southern India: what are the metabolic consequences 20 years later?

Nicolaï¹,

Grunnet²,

Poulsen³

et al. 2012

European Journal of Endocrinology

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Objective: Low birth weight (LBW) is common in the Indian population and may represent an important predisposing factor for type 2 diabetes (T2D) and the metabolic syndrome. Intensive metabolic examinations in ethnic LBW Asian Indians have been almost exclusively performed in immigrants living outside India. Therefore, we aimed to study the metabolic impact of being born with LBW in a rural non-migrant Indian population. Subjects and methods: One hundred and seventeen non-migrant, young healthy men were recruited from a birth cohort in a rural part of south India. The subjects comprised 61 LBW and 56 normal birth weight (NBW) men, with NBW men acting as controls. Subjects underwent a hyperinsulinaemic euglycaemic clamp, i.v. and oral glucose tolerance tests and a dual-energy X-ray absorptiometry scan. The parents' anthropometric status and metabolic parameters were assessed. Results: Men with LBW were shorter (167G6.4 vs 172G6.0 cm, P!0.0001), lighter (51.9G9 vs 55.4G7 kg, PZ0.02) and had a reduced lean body mass (42.1G5.4 vs 45.0G4.5 kg, PZ0.002) compared with NBW controls. After adjustment for height and weight, the LBW subjects had increased diastolic blood pressure (77G6 vs 75G6 mmHg, PZ0.01). Five LBW subjects had impaired glucose tolerance. In vivo insulin secretion and peripheral insulin action were similar in both the groups. Mothers of the LBW subjects were 3 cm shorter than the control mothers. Conclusion: Only subtle features of the metabolic syndrome and changes in body composition among LBW rural Indians were found. Whether other factors such as urbanisation and ageing may unmask more severe metabolic abnormalities may require a long-term follow-up.

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“…17,18 Hyperuricemia and hypertriglyceridemia are suggested to be associated with insulin resistance syndrome. [22][23][24] The association between insulin resistance, hyperuricemia, and hypertriglyceridemia are complicated. This might be expected from the fact that uric acid production is linked to glycolysis and that glycolysis is controlled by insulin.…”

Section: Discussionmentioning

confidence: 99%

The study of prevalence of hyperuricemia and metabolic syndrome in type 2 diabetes mellitus

Mundhe

Mhasde

2016

Int J Adv Med

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INTRODUCTIONType 2 diabetes mellitus (type 2 DM) is associated with cardiovascular complications, of which metabolic syndrome (Mets) plays a prominent role. The metabolic syndrome is a cluster of cardiovascular risk factors that is characterized by central obesity, insulin resistance, dyslipidemia and hypertension. 1 Hyperuricemia or elevated serum uric acid levels (SUA) is a biochemical entity that is gaining increasing importance as it is found by some researchers to be not only a cardiovascular risk factor but also plays a role in development of renal and metabolic diseases.2-4 Some reports on SUA and metabolic syndrome have noted that increased SUA concentration is associated with increased prevalence of some of the parameters of the metabolic syndrome like obesity, dyslipidemia and hypertension. 5,6 In these reports, the documented prevalence rates of hyperuricemia ranged from 13-19% with greater proportions of males having elevated levels of SUA compared to females. 5,6 Although SUA levels are usually higher in males than females, there is an increase in SUA ABSTRACT Background: Type 2 diabetes mellitus (Type 2 DM) is associated with cardiovascular complications, of which metabolic syndrome plays a prominent role. The metabolic syndrome is a cluster of cardiovascular risk factors characterized by central obesity, insulin resistance, dyslipidemia and hypertension. Hyperuricemia is gaining importance as cardiovascular risk factor and has role in renal and metabolic diseases. Our study was aimed to find out the prevalence of hyperuricemia and metabolic syndrome in type 2 DM and to evaluate association of hyperuricemia with metabolic syndrome. Methods: This observational longitudinal study was carried out on 150 patients of type 2 DM patients for determination of hyperuricemia and components of metabolic syndrome. Results: Metabolic syndrome was diagnosed in 68 patients (45.3%) with higher prevalence in males (53.4%) than females (33.9%). Hyperuricemia was found in 38 patients (25.3%) with higher prevalence in males (33%) than females (14.5%). Hyperuricemia and metabolic syndrome was found in 32 (21.3%) patients with higher prevalence among males (27.3%) than females (12.9%). The patients with hyperuricemia and metabolic syndrome compared to those without hyperuricemia and metabolic syndrome had higher mean age (63.16 Conclusions: Prevalence of hyperuricemia is higher in patients of type 2 diabetes with metabolic syndrome and is positively correlated with BMI, blood pressure and triglycerides and negatively correlated with HDL-C.

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Isolated low HDL cholesterol: an insulin-resistant state only in the presence of fasting hypertriglyceridemia.

Cited by 49 publications

References 0 publications

Isolated Hypertriglyceridemia: An Insulin-Resistant State with or without Low HDL Cholesterol

Isolated Hypertriglyceridemia: An Insulin-Resistant State with or without Low HDL Cholesterol

Born with low birth weight in rural Southern India: what are the metabolic consequences 20 years later?

The study of prevalence of hyperuricemia and metabolic syndrome in type 2 diabetes mellitus

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