Isolated luteinizing hormone (LH) elevation in a woman with secondary amenorrhea: a clue to the diagnosis of an inhibin B–producing thecoma and insights into the influence of inhibin B on LH

Donovan, Lois; Brain, Philippa; Duggan, Máire A.

doi:10.1016/j.fertnstert.2010.02.016

Cited by 15 publications

(12 citation statements)

References 20 publications

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“…It has been reported that the GnRH hormones are produced in the healthy granulosa cells of the ovary 23 . Earlier it has been suggested that in patients who are suffering from OC, there is an elevation in the levels of LH when compared to the healthy patients mainly due to the mutations which occur in the LH receptors 24 . Similarly, we found that the OC patients showed signi cantly higher levels of LH when compared to the normal levels among their respective controls.…”

Section: Resultmentioning

confidence: 99%

Disparities in Characteristics, Symptoms and mtDNA Influence on Ovarian Cancer Patients From South Indian Population

Iyer¹,

Venkatesan²,

Jayaramayya³

et al. 2020

Preprint

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Ovarian cancer (OC) is a complex multifactorial malignancy, ranking as second most common reproductive cancer in India. The purpose of this study was to compare whether different characteristics combined with hormonal and genetic influence among the urban, rural and tribal populations affected with OC would have a significant impact on OC incidence. To address this challenge, we designed a statistical approach that combines individual-level epidemiological data from both OC patients and controls from designed study populations using questionnaires. A total of (n=72) OC patients were obtained from several oncological clinics, hospitals and population-based surveys from various districts of South Indian population. Using validated hormonal biomarkers, we estimated hormonal profiles in both OC subjects and controls to measure the role of hormones in OC severity and incidence. Further we conducted mitochondrial gene sequencing, we found 5 nucleotide changes among which MT9140 C>T) was the predominant in OC subjects. In conclusion, this kind of study would be the first of its kind, where population-based epidemiological surveys serve as keys for comparing the characteristic factors and genetic influence associated with OC incidence. Hence, we strongly recommend that frequent conduction of epidemiological studies and health awareness camps would be beneficial to overcome such lethal conditions.

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Section: Resultmentioning

confidence: 99%

Disparities in Characteristics, Symptoms and mtDNA Influence on Ovarian Cancer Patients From South Indian Population

Iyer¹,

Venkatesan²,

Jayaramayya³

et al. 2020

Preprint

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“…Inhibin B levels elevated to this extent are extremely rare for thecomas or fibrothecomas. Previous cases have been reported in the reproductive endocrinology literature ( Table 1 ) ( Hugon-Rodin et al, 2016 , Meyer et al, 2000 , Donovan et al, 2010 , Van Liempt et al, 2012 ). Three of the 4 cases were premenopausal women presenting with secondary amenorrhea and infertility.…”

Section: Discussionmentioning

confidence: 99%

Benign ovarian thecoma with markedly elevated serum inhibin B levels mimicking adult granulosa cell tumor

Carballo

Gyorfi

Stanic

et al. 2020

Gynecologic Oncology Reports

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“…The Ovarian granulosa cell cancer may have a role in the formation of the gonadotropin-releasing hormone during the production of tumour cell in Ovarian car-cinoma patient. Another probability for the increasing of Luteinizing hormone in Ovarian granulosa cancer cells is linked to the mutation of Luteinizing hormone receptor, which is uncommon aetiology of amenorrhea linked with increasing levels of Luteinizing hormone (Donovan et al, 2010). On the one hand, indirectly, the cancer cell may have released some compound that causes an elevation in the circulating levels of Luteinizing hormone.…”

Section: Serum Levels Of Luteinizing Hormone (Lh)mentioning

confidence: 99%

Variation of Serum Interleukin, Gonadotropins hormone and Steroid hormone levels in women with Ovarian Cancer

Ali¹,

Ismail²

2020

ijrps

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Ovarian cancer has high mortality and delayed diagnosis. Inflammation is considered as a risk for ovarian carcinoma, and it contributes to all grades of tumour progression. Inflammation involved in the development of cancer cell and can be caused by an increase in the formation of pro-inflammatory cytokines. This research was conducted to assess serum Interleukin, Gonadotropins hormone and Steroid hormone levels in ovarian cancer patients and to assess their impact in disease action. The present study is composed of 85 women (mean age = 62.03±12.4 yrs) with clinically and pathologically confirmed ovarian cancer and 65 healthy women as a control group (mean age = 61±12.1 yrs). The measured biochemical parameters included: the level of serum gonadotropins(LH, luteinizing hormone; FSH, follicle-stimulating hormone), steroid hormones (estrogen, progesterone, prolactin, testosterone) and Interleukin (IL-4, IL-6, and IL-8). The results demonstrated significantly high values of steroid hormones (p<0.01, p<0.01, p<0.05,p<0.002, p<0.01 (estrogen, progesterone, prolactin, testosterone) and significantly high ( p<0.001, p<0.002, p<0.01)values in (IL-4, IL-6, and IL-8) in ovarian cancer in comparison with control group. There were also significantly high (p<0.0001, p<0.05 values of sera LH and FSH in women ovarian cancer in comparison with the control group. p<0.01, p<0.001) respectively in ovarian cancer in comparison with the control group. An elevation of serum steroid hormone, gonadotropins, and Interleukin levels in cases of ovarian carcinoma in our study is important as a marker of the disease.

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Isolated luteinizing hormone (LH) elevation in a woman with secondary amenorrhea: a clue to the diagnosis of an inhibin B–producing thecoma and insights into the influence of inhibin B on LH

Cited by 15 publications

References 20 publications

Disparities in Characteristics, Symptoms and mtDNA Influence on Ovarian Cancer Patients From South Indian Population

Disparities in Characteristics, Symptoms and mtDNA Influence on Ovarian Cancer Patients From South Indian Population

Benign ovarian thecoma with markedly elevated serum inhibin B levels mimicking adult granulosa cell tumor

Variation of Serum Interleukin, Gonadotropins hormone and Steroid hormone levels in women with Ovarian Cancer

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