Isolated Native Tricuspid Valve Endocarditis in a Nonintravenous Drug User

Shibru, Habtewold; Greffie, Ermias Shenkutie; Abay, Zenahbezu; Muhie, Oumer Abdu

doi:10.1155/2020/8812597

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…Infective endocarditis is a disease that involves the endocardial surface of the heart, more commonly affecting the heart valves [1]. While right-sided infective endocarditis is much less common than left-sided infective endocarditis, accounting for 5% to 10% of all infective endocarditis cases and usually occurs with a predisposing risk factor [2], patients presenting with no primary cause have also been described [3][4][5]. The present case involved a left-sided breast abscess associated with tricuspid valve endocarditis.…”

Section: Introductionmentioning

confidence: 83%

“…Staphylococcus aureus is the most common organism causing infective endocarditis of the tricuspid valve in patients with underlying risk factors [ 2 ]. It also remains the most common pathogen in rare reports where tricuspid valve infective endocarditis occurred following psoas abscess [ 8 ], septic arthritis [ 4 ], septic abortion [ 17 ], or in cases with no clear predisposing condition [ 3 , 5 ]. Similarly, in our case, Staphylococcus aureus was the culprit pathogen following a left-sided breast skin abscess.…”

Section: Discussionmentioning

confidence: 99%

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Native Tricuspid Valve Infective Endocarditis After Breast Skin Abscess

Sami,

Ali,

Pasha

2023

Cureus

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Tricuspid valve infective endocarditis is a rare disease in non-intravenous drug users. It can occur with congenital heart disease, foreign bodies such as central venous catheters and intracardiac devices, and in immunocompromised patients. In the present case, there was a left-sided breast abscess associated with tricuspid valve endocarditis in a patient without any apparent underlying causative factors. We present a case of a young female in her early 20s who arrived at the emergency department with complaints of fever, epistaxis, and vomiting. On clinical examination, she was found to have a fading 2 cm pinkish left breast skin lesion, which had formed on her breast 10 days ago. Blood cultures identified methicillin-resistant Staphylococcus aureus in the blood. A CT scan of the chest, abdomen, and pelvis revealed splenomegaly and an infective focus in the spleen. Subsequent echocardiography confirmed the diagnosis of infective endocarditis of the native tricuspid valve, which was treated with intravenous vancomycin. There was no history of intravenous drug abuse, congenital heart disease, placement of an intracardiac device, central venous catheter, or an immunocompromised state in this patient. Therefore, the diagnosis of infective endocarditis, characterized by a native tricuspid valve vegetation identified as a consequence of a left breast skin abscess, was made. A high index of suspicion is required for a non-specific presentation of tricuspid valve infective endocarditis and in the absence of any prior history of risk factors for right-sided infective endocarditis. Timely initiation of antibiotics depends on a preliminary clinical diagnosis.

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Section: Introductionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Native Tricuspid Valve Infective Endocarditis After Breast Skin Abscess

Sami,

Ali,

Pasha

2023

Cureus

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Isolated tricuspid valve endocarditis in immunocompetent juvenile patients: a series of three cases

et al. 2021

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Right-sided native valve infective endocarditis is common in patients with congenital or valvular heart disease, intracardiac device, central venous catheter and intravenous drug abuse, usually manifesting in adulthood. However, in the absence of predisposing risk factors and in younger age groups, this disease may pose a diagnostic challenge. We report a case series of three juvenile patients with isolated tricuspid valve infective endocarditis without any risk factors and paucity of cardiovascular findings in two of them, in an attempt to highlight the importance of maintaining a high index of suspicion to arrive a timely diagnosis.

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Mortality due to Sepsis and Its Associated Factors Among Patients Admitted to Intensive Care Units of Southern Amhara Public Hospitals, Ethiopia

Getu,

Legese,

Gashu

et al. 2024

BioMed Research International

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Introduction: Although intensive care units (ICUs) are where severe and complicated cases are managed, there is limited evidence on treatment outcomes in Ethiopia. Therefore, this study is aimed at assessing the magnitude and associated factors of mortality among patients with sepsis admitted to ICUs at southern Amhara public hospitals, Ethiopia.Methods: A total of 547 medical records of patients with sepsis admitted to the ICUs at Injibara, Debre Markos, and Debre Tabor hospitals in the past 3 years were retrieved from August 10–31, 2022. Multivariable logistic regression analyses were conducted and adjusted odds ratios (AOR) with a 95% confidence interval (CI) were reported, and a p value < 0.05 was set to declare the significance of the association.Results: In this study, 46.2% (95% CI: 41.7%–50.3%) of patients with sepsis died during their ICU stay. Respiratory, gastrointestinal, and urinary tract infections contributed to 32.3%, 25.8%, and 9.6% of mortality, respectively. Individuals aged 60 and above (AOR: 4.07; 95% CI: 2.23–7.44), those with a Glasgow Coma Scale ≤ 10 at admission (AOR: 11.27; 95% CI: 4.64–27.37), respiratory site of infection (AOR: 5.38; 95% CI: 2.94–9.86), creatinine level > 1.1 mg/dL (AOR: 4.20; 95% CI: 2.33–7.60), vasopressor use (AOR: 3.13; 95% CI:1.66–5.95), initiation of antibiotics 1–3 h after admission (AOR: 2.80; 95% CI: 1.64–4.76), and a hospital stay of more than 20 days (AOR: 3.44; 95% CI: 1.40–8.46) were significantly associated with mortality.Conclusion: Overall, the mortality rate among patients with sepsis admitted to ICUs in southern Amhara public hospitals was high. Mainly, death was attributed to respiratory infections. Elderly patients and those with deteriorated clinical conditions at admission were at higher risk. Therefore, special attention is needed for elderly patients admitted with respiratory infections, antibiotics should be initiated as early as possible, and interventions must be designed to shorten the length of stay in ICUs.

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Isolated Native Tricuspid Valve Endocarditis in a Nonintravenous Drug User

Cited by 3 publications

References 14 publications

Native Tricuspid Valve Infective Endocarditis After Breast Skin Abscess

Native Tricuspid Valve Infective Endocarditis After Breast Skin Abscess

Isolated tricuspid valve endocarditis in immunocompetent juvenile patients: a series of three cases

Mortality due to Sepsis and Its Associated Factors Among Patients Admitted to Intensive Care Units of Southern Amhara Public Hospitals, Ethiopia

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