Isolated non-cardiogenic pulmonary edema — A rare complication of MDMA toxicity

Haaland, Astrid; Warman, Elliot; Pushkar, Illya; Likourezos, Antonios; Friedman, Matt S.

doi:10.1016/j.ajem.2017.06.040

Cited by 4 publications

(5 citation statements)

References 28 publications

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“…b, [109][110][111]115,119 The distribution can be perihilar or diffuse. 112,117,119,120 The 1 dog with cytarabine-associated pulmonary edema showed a multilobar patchy alveolar pattern. 27 Thoracic CT findings in humans with drug-related NCPE have been described as diffuse, bilateral alveolar and interstitial infiltrates.…”

Section: Diagnosismentioning

confidence: 99%

“…This may be more apparent after the patient starts breathing again after reversal with naloxone 119 . Methylenedioxymethamphetamine is a synthetic amphetamine derivative, which releases endogenous catecholamines, which can cause a sympathetic surge and NCPE development similar to NPE 120 . Synthetic cannabinoids may cause NCPE through seizures or respiratory depression 108 …”

Section: Drug Induced Ncpementioning

confidence: 99%

“…Thoracic radiographs in people with drug‐induced NCPE may show bilateral or unilateral alveolar edema with air bronchograms, ranging from mild to complete opacification of all lung fields. b, 109–111,115,119 The distribution can be perihilar or diffuse 112,117,119,120 . The 1 dog with cytarabine‐associated pulmonary edema showed a multilobar patchy alveolar pattern 27 …”

Section: Drug Induced Ncpementioning

confidence: 99%

“…Additionally, in many drug reactions complications other than pulmonary edema may contribute to the prognosis. b, 11,27,29,108–120 However, most reported cases in people seem to have a favorable outcome with short hospitalization times. b, 109–115,117,119,120 …”

Section: Drug Induced Ncpementioning

confidence: 99%

“…b, 11,27,29,108–120 However, most reported cases in people seem to have a favorable outcome with short hospitalization times. b, 109–115,117,119,120 …”

Section: Drug Induced Ncpementioning

confidence: 99%

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Noncardiogenic pulmonary edema in small animals

Unger

Martin

2023

J Vet Emergen Crit Care

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Objective To review various types of noncardiogenic pulmonary edema (NCPE) in cats and dogs. Etiology NCPE is an abnormal fluid accumulation in the lung interstitium or alveoli that is not caused by cardiogenic causes or fluid overload. It can be due to changes in vascular permeability, hydrostatic pressure in the pulmonary vasculature, or a combination thereof. Possible causes include inflammatory states within the lung or in remote tissues (acute respiratory distress syndrome [ARDS]), airway obstruction (post‐obstructive pulmonary edema), neurologic disease such as head trauma or seizures (neurogenic pulmonary edema), electrocution, after re‐expansion of a collapsed lung or after drowning. Diagnosis Diagnosis of NCPE is generally based on history, physical examination, and diagnostic imaging. Radiographic findings suggestive of NCPE are interstitial to alveolar pulmonary opacities in the absence of signs of left‐sided congestive heart failure or fluid overload such as cardiomegaly or congested pulmonary veins. Computed tomography and edema fluid analysis may aid in the diagnosis, while some forms of NCPE require additional findings to reach a diagnosis. Therapy The goal of therapy for all types of NCPE is to preserve tissue oxygenation and reduce the work of breathing. This may be achieved by removing the inciting cause (eg, airway obstruction) and cage rest in mild cases and supplemental oxygen in moderate cases and may require mechanical ventilation in severe cases. Prognosis Prognosis is generally good for most causes of veterinary NCPE except for ARDS, although data are scarce for some etiologies of NCPE.

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Section: Diagnosismentioning

confidence: 99%

Section: Drug Induced Ncpementioning

confidence: 99%

Section: Drug Induced Ncpementioning

confidence: 99%

Section: Drug Induced Ncpementioning

confidence: 99%

“…b, 11,27,29,108–120 However, most reported cases in people seem to have a favorable outcome with short hospitalization times. b, 109–115,117,119,120 …”

Section: Drug Induced Ncpementioning

confidence: 99%

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