Isolated Non-Hodgkin’s Malignant Lymphoma of the Larynx Presenting as a Large Pedunculated Tumor

Aim To describe a case of diffuse large B cell lymphoma (DLBCL) presenting as a pedunculated/polypoidal mass in upper aero-digestive tract and to review pertinent literature. Methods Using Pubmed advanced search, case reports and literature were reviewed for this condition.Results A 16 year old female presented with history of shortness of breath when lying down, voice change, progressing odynophagia and feeling of throat lump. Direct visualization showed flower like pedunculated mass, attached to the left lateral oropharyngeal wall. Excision of this mass showed DLBCL and no disease anywhere. She received four cycles of Rituximab ? CHOP and is diseasefree for 4 years. Only 21 cases of pedunculated upper aerodigestive tract lymphomas have been reported in literature. Median age 53 years (16-90 years), males 80 %, females 20 %, localized disease (65 %). Common sites were endobronchial polypoid lesion (7 cases), nasal polyps (7), nasopharyngeal polyps (2), nose and paranasal sinus (1), laryngeal polyp (2) and one each as gum, esophagus and oropharyngeal (current case) polyp. Pathology showed aggressive lymphoma in 94 %. Conclusion DLBCL as an extranodal pedunculated lesion in the oropharynx is very rare. Careful pathological evaluation is essential for these lesions for proper diagnosis.

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“…There are limited case reports in the literature [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Upper Aero-Digestive Tract Lymphomas Presenting as Polypoidal/Pedunculated Lesions: Case Report and Review of Literature

Akhtar

Rana

Aldei

et al. 2013

Head and Neck Pathol

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“…97,[181][182][183][184][185] Several patients have had concurrent laryngeal squamous cell carcinoma or other malignancies. 184,185 Individual case reports have described patients with Sjögren's syndrome, 186 rheumatoid arthritis, 187 or chronic laryngitis secondary to extraesophageal reflux with Helicobacter pylori gastritis. 188 In rare cases patients are HIV positive 97,183 or have another underlying immunodeficiency.…”

Section: Differential Diagnosis Of Hodgkin's Lymphoma Of the Thyroidmentioning

confidence: 99%

Lymphomas of the Head and Neck

Ferry¹

2011

Extranodal Lymphomas

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“…Median age for occurrence of PLLs is the 7 th decade but can present in any groups [4,5]. The presenting symptoms are similar to squamous cell laryngeal cancers as; hoarseness of voice, foreign body sensation, dysphagia, stridor, dyspnea and cervical lymphadenopathy [6]. Immunohistochemistry is only confirmatory for diagnosing PLLs as radiological features are often similar to primary squamous cell laryngeal cancers [7].…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological features and treatment outcomes of primary laryngeal lymphomas in saudi population

Bayoumi¹,

Maklad²,

Tunio³

et al. 2013

Hematol Leuk

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Background: Primary laryngeal lymphomas (PLLs) are rare and account for 1% -3% of all laryngeal neoplasms. Our aim was to describe the symptomology, diagnosis, histological variants and treatment outcomes of PLL in Saudi population. Materials and methods: Retrospective review of medical records of patients with laryngeal neoplasms, who were treated in our center in the period from July 2005 to December 2012, was performed. Demographic, radiologic and histopathological features and treatment outcomes were collected. Results: Among 57 records of patients with laryngeal carcinoma, two (3.51%) patients were diagnosed with PLLs. The frequent clinical presentation was hoarseness of voice. One (50%) patient hadmarginal zone B-cell mucosa-associated lymphoid tissue (MALT) lymphomas and other (50%) patient had T-Cell lymphoma (TCL). Both patients were treated with involved field radiotherapy 30-36 Gy in 15-18 fractions using RapidArc intensity modulated radiation therapy (IMRT). Median follow up was 12 months (6-14) with overall survival and disease free survival rates of 100% and 100%. Conclusion: PLLs are uncommon but with better outcomes than other sites lymphomas. Efforts are required for incorporation of immunohistochemical methodsto reach proper diagnosis and multimodality approach to improve the diagnosis and treatment outcomes.

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Isolated Non-Hodgkin’s Malignant Lymphoma of the Larynx Presenting as a Large Pedunculated Tumor

Cited by 9 publications

References 6 publications

Upper Aero-Digestive Tract Lymphomas Presenting as Polypoidal/Pedunculated Lesions: Case Report and Review of Literature

Upper Aero-Digestive Tract Lymphomas Presenting as Polypoidal/Pedunculated Lesions: Case Report and Review of Literature

Lymphomas of the Head and Neck

Clinicopathological features and treatment outcomes of primary laryngeal lymphomas in saudi population

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