Isolated Ocular Surface Squamous Neoplasia in a Renal Transplant Recipient

Introducción: Las enfermedades cutáneas son frecuentes en los pacientes trasplantados renales, por lo cual el monitoreo de la piel es necesario para realizar un diagnóstico precoz e iniciar tratamiento temprano.Objetivo: Determinar la prevalencia de las manifestaciones cutáneas en pacientes con trasplante renal. Materiales y métodos: Se evaluaron en consulta de dermatología 86 pacientes del programa de trasplante renal del Hospital Universitario San Ignacio.Resultados: Las infecciones de piel fueron las manifestaciones más prevalentes, y dentro de estas las más frecuentes fueron las micosis superficiales presentes, en un 48 % de los pacientes; seguidas por las infecciones virales, en un 20 %, y las bacterianas, en un 15 %. Se encontraron dos casos de cáncer de piel: un carcinoma basocelular y un sarcoma de Kaposi. Doce pacientes tuvieron queratosis actínicas consideradas lesiones premalignas.Conclusión: Los resultados del estudio evidencian la necesidad de realizar un examen dermatológico rutinario en los pacientes trasplantados para detectar tempranamente la presencia de lesiones cutáneas y, de esta manera, iniciar un manejo oportuno. Los hallazgos más comunes fueron las micosis superficiales.

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Evaluation of the radiotherapy management of ocular surface squamous neoplasia in a high HIV prevalence setting- a retrospective review

Ndlovu

Ndarukwa

Kadzatsa

et al. 2016

Infect Agents Cancer

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BackgroundThis article evaluates a single institute’s radiotherapy management of OSSN, a previously regarded as rare malignancy, for possible future development of strategies to clearly define the role of adjuvant radiotherapy in improving treatment outcomes.Materials and methodsA retrospective review of 153 patients treated from January 2003 to December 2009.ResultsThere was no difference in OSSN prevalence by gender (male to female ratio 1.07). Of 80/153 patients tested 79 (98.8 %) were HIV positive. Most patients (62.9 %) had prior orbital exenteration. Moderately and poorly differentiated grade (82.3 %) was associated with significantly higher stage and incidence of positive regional lymph nodes. External beam therapy dose mostly used was 60Gy in 30 fractions at 200 cGy per fraction in 5 fractions per week (34.8 %). 90Strontium therapy was given to 13.5 % (60Gy in 6 fractions at 10Gy per fraction weekly). Favourable response (complete and partial) was seen in about 80 % of patients associated with higher total doses. Regional lymph node positivity was associated with poorer outcome.ConclusionAdjuvant radiotherapy could have an important role in the management of patients presenting with locally advanced OSSN who are mostly HIV positive in developing countries. Prospective studies to evaluate the role of radiotherapy with or without chemotherapy in the management of OSSN in these settings are warranted.

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Isolated Ocular Surface Squamous Neoplasia in a Renal Transplant Recipient

Cited by 3 publications

References 7 publications

Periocular and ocular surface nonmelanoma skin cancer

Periocular and ocular surface nonmelanoma skin cancer

Lesiones cutáneas en pacientes con trasplante renal en el Hospital Universitario San Ignacio

Evaluation of the radiotherapy management of ocular surface squamous neoplasia in a high HIV prevalence setting- a retrospective review

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